The effect of tacrolimus-induced toxicity on metabolic profiling in target tissues of mice
Abstract Tacrolimus (Tac) is a common immunosuppressant that used in organ transplantation. However, its therapeutic index is narrow, and it is prone to adverse side effects, along with an increased risk of toxicity, namely, cardio-, nephro-, hepato-, and neurotoxicity. Prior metabolomic investigati...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2022-11-01
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Series: | BMC Pharmacology and Toxicology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s40360-022-00626-x |