The effect of tacrolimus-induced toxicity on metabolic profiling in target tissues of mice

The effect of tacrolimus-induced toxicity on metabolic profiling in target tissues of mice

Abstract Tacrolimus (Tac) is a common immunosuppressant that used in organ transplantation. However, its therapeutic index is narrow, and it is prone to adverse side effects, along with an increased risk of toxicity, namely, cardio-, nephro-, hepato-, and neurotoxicity. Prior metabolomic investigati...

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Bibliographic Details
Main Authors: Dadi Xie, Jinxiu Guo, Ruili Dang, Yanan Li, Qingying Si, Wenxiu Han, Shan Wang, Ning Wei, Junjun Meng, Linlin Wu
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Pharmacology and Toxicology
Subjects:
Calcineurin inhibitor
Drug toxicity
Gas chromatography−mass spectrometry
Metabolome
Main tissues
Online Access:https://doi.org/10.1186/s40360-022-00626-x

Internet

https://doi.org/10.1186/s40360-022-00626-x

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