The role of the sex hormone-gut microbiome axis in tumor immunotherapy
ABSTRACTAccumulating evidence suggested that both gut microbiome and sex play a critical role in the efficacy of immune checkpoint blockade therapy. Considering the reciprocal relationship between sex hormones and gut microbiome, the sex hormone-gut microbiome axis may participate in the regulation...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2185035 |
| _version_ | 1827303730175803392 |
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| author | Luoyang Wang Lei Tang Dongchang Zhai Meiying Song Wei Li Shuo Xu Suli Jiang Haining Meng Jie Liang Yingying Wang Bei Zhang |
| author_facet | Luoyang Wang Lei Tang Dongchang Zhai Meiying Song Wei Li Shuo Xu Suli Jiang Haining Meng Jie Liang Yingying Wang Bei Zhang |
| author_sort | Luoyang Wang |
| collection | DOAJ |
| description | ABSTRACTAccumulating evidence suggested that both gut microbiome and sex play a critical role in the efficacy of immune checkpoint blockade therapy. Considering the reciprocal relationship between sex hormones and gut microbiome, the sex hormone-gut microbiome axis may participate in the regulation of the response to immune checkpoint inhibitors (ICIs). In this review, it was attempted to summarize the current knowledge about the influences of both sex and gut microbiome on the antitumor efficacy of ICIs and describe the interaction between sex hormones and gut microbiome. Accordingly, this review discussed the potential of enhancing the antitumor efficacy of ICIs through regulating the levels of sex hormones through manipulation of gut microbiome. Collectively, this review provided reliable evidence concerning the role of the sex hormone-gut microbiome axis in tumor immunotherapy. |
| first_indexed | 2024-03-11T14:20:23Z |
| format | Article |
| id | doaj.art-701fe4b9231e4613bed9a22bbba27b46 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:07:18Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-701fe4b9231e4613bed9a22bbba27b462024-03-28T22:38:20ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2185035The role of the sex hormone-gut microbiome axis in tumor immunotherapyLuoyang Wang0Lei Tang1Dongchang Zhai2Meiying Song3Wei Li4Shuo Xu5Suli Jiang6Haining Meng7Jie Liang8Yingying Wang9Bei Zhang10Department of Immunology, School of Basic Medicine, Qingdao University, Qingdao, ChinaDepartment of Special Medicine, School of Basic Medicine, Qingdao University, Qingdao, ChinaDepartment of Special Medicine, School of Basic Medicine, Qingdao University, Qingdao, ChinaDepartment of Immunology, School of Basic Medicine, Qingdao University, Qingdao, ChinaDepartment of Immunology, School of Basic Medicine, Qingdao University, Qingdao, ChinaDepartment of Immunology, School of Basic Medicine, Qingdao University, Qingdao, ChinaDepartment of Immunology, School of Basic Medicine, Qingdao University, Qingdao, ChinaSchool of Emergency Medicine, Qingdao University, Qingdao, ChinaDepartment of Immunology, School of Basic Medicine, Qingdao University, Qingdao, ChinaShandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, ChinaDepartment of Immunology, School of Basic Medicine, Qingdao University, Qingdao, ChinaABSTRACTAccumulating evidence suggested that both gut microbiome and sex play a critical role in the efficacy of immune checkpoint blockade therapy. Considering the reciprocal relationship between sex hormones and gut microbiome, the sex hormone-gut microbiome axis may participate in the regulation of the response to immune checkpoint inhibitors (ICIs). In this review, it was attempted to summarize the current knowledge about the influences of both sex and gut microbiome on the antitumor efficacy of ICIs and describe the interaction between sex hormones and gut microbiome. Accordingly, this review discussed the potential of enhancing the antitumor efficacy of ICIs through regulating the levels of sex hormones through manipulation of gut microbiome. Collectively, this review provided reliable evidence concerning the role of the sex hormone-gut microbiome axis in tumor immunotherapy.https://www.tandfonline.com/doi/10.1080/19490976.2023.2185035Gut microbiomesex hormonesimmune checkpoint inhibitorstumor immunotherapy |
| spellingShingle | Luoyang Wang Lei Tang Dongchang Zhai Meiying Song Wei Li Shuo Xu Suli Jiang Haining Meng Jie Liang Yingying Wang Bei Zhang The role of the sex hormone-gut microbiome axis in tumor immunotherapy Gut Microbes Gut microbiome sex hormones immune checkpoint inhibitors tumor immunotherapy |
| title | The role of the sex hormone-gut microbiome axis in tumor immunotherapy |
| title_full | The role of the sex hormone-gut microbiome axis in tumor immunotherapy |
| title_fullStr | The role of the sex hormone-gut microbiome axis in tumor immunotherapy |
| title_full_unstemmed | The role of the sex hormone-gut microbiome axis in tumor immunotherapy |
| title_short | The role of the sex hormone-gut microbiome axis in tumor immunotherapy |
| title_sort | role of the sex hormone gut microbiome axis in tumor immunotherapy |
| topic | Gut microbiome sex hormones immune checkpoint inhibitors tumor immunotherapy |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2185035 |
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