Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination

Neuropathic pain caused by nerve injury or disease remains a major challenge for modern medicine worldwide. Most of the pathogenic mechanisms underlying neuropathic pain are centered on neuronal mechanisms. Accumulating evidence suggests that non-neuronal cells, especially glial cells, also play act...

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Main Authors: Zhongya Wei, Ying Fei, Wenfeng Su, Gang Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00116/full
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author Zhongya Wei
Ying Fei
Wenfeng Su
Gang Chen
Gang Chen
author_facet Zhongya Wei
Ying Fei
Wenfeng Su
Gang Chen
Gang Chen
author_sort Zhongya Wei
collection DOAJ
description Neuropathic pain caused by nerve injury or disease remains a major challenge for modern medicine worldwide. Most of the pathogenic mechanisms underlying neuropathic pain are centered on neuronal mechanisms. Accumulating evidence suggests that non-neuronal cells, especially glial cells, also play active roles in the initiation and resolution of pain. The preponderance of evidence has implicated central nervous system (CNS) glial cells, i.e., microglia and astrocytes, in the control of pain. The role of Schwann cells in neuropathic pain remains poorly understood. Schwann cells, which detect nerve injury and provide the first response, play a critical role in the development and maintenance of neuropathic pain. The cells respond to nerve injury by changing their phenotype, proliferating and interacting with nociceptive neurons by releasing glial mediators (growth factors, cytokines, chemokines, and biologically active small molecules). In addition, receptors expressed in active Schwann cells have the potential to regulate different pain conditions. In this review article, we will provide and discuss emerging evidence by integrating recent advances related to Schwann cells and neuropathic pain.
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spelling doaj.art-7020cf16fb2a44c380fd847a7c2826d22022-12-21T20:05:59ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-03-011310.3389/fncel.2019.00116445946Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and MyelinationZhongya Wei0Ying Fei1Wenfeng Su2Gang Chen3Gang Chen4Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, ChinaDepartment of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, ChinaNeuropathic pain caused by nerve injury or disease remains a major challenge for modern medicine worldwide. Most of the pathogenic mechanisms underlying neuropathic pain are centered on neuronal mechanisms. Accumulating evidence suggests that non-neuronal cells, especially glial cells, also play active roles in the initiation and resolution of pain. The preponderance of evidence has implicated central nervous system (CNS) glial cells, i.e., microglia and astrocytes, in the control of pain. The role of Schwann cells in neuropathic pain remains poorly understood. Schwann cells, which detect nerve injury and provide the first response, play a critical role in the development and maintenance of neuropathic pain. The cells respond to nerve injury by changing their phenotype, proliferating and interacting with nociceptive neurons by releasing glial mediators (growth factors, cytokines, chemokines, and biologically active small molecules). In addition, receptors expressed in active Schwann cells have the potential to regulate different pain conditions. In this review article, we will provide and discuss emerging evidence by integrating recent advances related to Schwann cells and neuropathic pain.https://www.frontiersin.org/article/10.3389/fncel.2019.00116/fullSchwann cellsneuropathic painreceptorsglial mediatorsmyelination
spellingShingle Zhongya Wei
Ying Fei
Wenfeng Su
Gang Chen
Gang Chen
Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination
Frontiers in Cellular Neuroscience
Schwann cells
neuropathic pain
receptors
glial mediators
myelination
title Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination
title_full Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination
title_fullStr Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination
title_full_unstemmed Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination
title_short Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination
title_sort emerging role of schwann cells in neuropathic pain receptors glial mediators and myelination
topic Schwann cells
neuropathic pain
receptors
glial mediators
myelination
url https://www.frontiersin.org/article/10.3389/fncel.2019.00116/full
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AT wenfengsu emergingroleofschwanncellsinneuropathicpainreceptorsglialmediatorsandmyelination
AT gangchen emergingroleofschwanncellsinneuropathicpainreceptorsglialmediatorsandmyelination
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