Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination
Neuropathic pain caused by nerve injury or disease remains a major challenge for modern medicine worldwide. Most of the pathogenic mechanisms underlying neuropathic pain are centered on neuronal mechanisms. Accumulating evidence suggests that non-neuronal cells, especially glial cells, also play act...
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Format: | Article |
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Frontiers Media S.A.
2019-03-01
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Series: | Frontiers in Cellular Neuroscience |
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Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00116/full |
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author | Zhongya Wei Ying Fei Wenfeng Su Gang Chen Gang Chen |
author_facet | Zhongya Wei Ying Fei Wenfeng Su Gang Chen Gang Chen |
author_sort | Zhongya Wei |
collection | DOAJ |
description | Neuropathic pain caused by nerve injury or disease remains a major challenge for modern medicine worldwide. Most of the pathogenic mechanisms underlying neuropathic pain are centered on neuronal mechanisms. Accumulating evidence suggests that non-neuronal cells, especially glial cells, also play active roles in the initiation and resolution of pain. The preponderance of evidence has implicated central nervous system (CNS) glial cells, i.e., microglia and astrocytes, in the control of pain. The role of Schwann cells in neuropathic pain remains poorly understood. Schwann cells, which detect nerve injury and provide the first response, play a critical role in the development and maintenance of neuropathic pain. The cells respond to nerve injury by changing their phenotype, proliferating and interacting with nociceptive neurons by releasing glial mediators (growth factors, cytokines, chemokines, and biologically active small molecules). In addition, receptors expressed in active Schwann cells have the potential to regulate different pain conditions. In this review article, we will provide and discuss emerging evidence by integrating recent advances related to Schwann cells and neuropathic pain. |
first_indexed | 2024-12-19T20:55:01Z |
format | Article |
id | doaj.art-7020cf16fb2a44c380fd847a7c2826d2 |
institution | Directory Open Access Journal |
issn | 1662-5102 |
language | English |
last_indexed | 2024-12-19T20:55:01Z |
publishDate | 2019-03-01 |
publisher | Frontiers Media S.A. |
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series | Frontiers in Cellular Neuroscience |
spelling | doaj.art-7020cf16fb2a44c380fd847a7c2826d22022-12-21T20:05:59ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-03-011310.3389/fncel.2019.00116445946Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and MyelinationZhongya Wei0Ying Fei1Wenfeng Su2Gang Chen3Gang Chen4Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, ChinaKey Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, ChinaDepartment of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, ChinaNeuropathic pain caused by nerve injury or disease remains a major challenge for modern medicine worldwide. Most of the pathogenic mechanisms underlying neuropathic pain are centered on neuronal mechanisms. Accumulating evidence suggests that non-neuronal cells, especially glial cells, also play active roles in the initiation and resolution of pain. The preponderance of evidence has implicated central nervous system (CNS) glial cells, i.e., microglia and astrocytes, in the control of pain. The role of Schwann cells in neuropathic pain remains poorly understood. Schwann cells, which detect nerve injury and provide the first response, play a critical role in the development and maintenance of neuropathic pain. The cells respond to nerve injury by changing their phenotype, proliferating and interacting with nociceptive neurons by releasing glial mediators (growth factors, cytokines, chemokines, and biologically active small molecules). In addition, receptors expressed in active Schwann cells have the potential to regulate different pain conditions. In this review article, we will provide and discuss emerging evidence by integrating recent advances related to Schwann cells and neuropathic pain.https://www.frontiersin.org/article/10.3389/fncel.2019.00116/fullSchwann cellsneuropathic painreceptorsglial mediatorsmyelination |
spellingShingle | Zhongya Wei Ying Fei Wenfeng Su Gang Chen Gang Chen Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination Frontiers in Cellular Neuroscience Schwann cells neuropathic pain receptors glial mediators myelination |
title | Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination |
title_full | Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination |
title_fullStr | Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination |
title_full_unstemmed | Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination |
title_short | Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination |
title_sort | emerging role of schwann cells in neuropathic pain receptors glial mediators and myelination |
topic | Schwann cells neuropathic pain receptors glial mediators myelination |
url | https://www.frontiersin.org/article/10.3389/fncel.2019.00116/full |
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