The frequency of HLA A, B, C, DP, DQ, DR allele in patients of Turkish and Syrian nationals with allogeneic stem cell transplantation
BACKGROUND: In allogeneic stem cell transplantation, donor and recipient HLA tissue compatibility is essential for the success of stem cell transplantation. HLA tissue compatibility percentage is the most important parameter that increases the success of transplantation in donor selection. Pretransp...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Iraqi Journal of Hematology |
| Subjects: | |
| Online Access: | http://www.ijhonline.org/article.asp?issn=2072-8069;year=2022;volume=11;issue=2;spage=110;epage=117;aulast=Kaya |
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| author | Ahmet Kaya Mehmet Ali Erkurt İrfan Kuku Emin Kaya İlhami Berber Soykan Biçim Emine Hidayet Fatma Hilal Yağin Ahmet Sarıcı |
| author_facet | Ahmet Kaya Mehmet Ali Erkurt İrfan Kuku Emin Kaya İlhami Berber Soykan Biçim Emine Hidayet Fatma Hilal Yağin Ahmet Sarıcı |
| author_sort | Ahmet Kaya |
| collection | DOAJ |
| description | BACKGROUND: In allogeneic stem cell transplantation, donor and recipient HLA tissue compatibility is essential for the success of stem cell transplantation. HLA tissue compatibility percentage is the most important parameter that increases the success of transplantation in donor selection. Pretransplant HLA tissue typing can be looked at in low and high resolution according to the facilities of the center and the urgency of transplantation. Many centers evaluate HLA HLA-A, B, C, DP, DQ, DR tissue types before allogeneic bone marrow transplantation. HLA tissue types differ in many races and even between unrelated individuals of the same race.
AIMS: This study aimed to show the common human leukocyte antigen (HLA) rates and differences in Syrian and Turkish ethnicity patients who underwent allogeneic stem cell transplantation in our center.
MATERIALS AND METHODS: HLA tissue similarities between Turkish and Syrian patients were revealed by examining the HLA tissue records of Turkish and Syrian patients who applied to the bone marrow transplant unit of Inonu University Turgut Ozal Medical Center between December 2009 and November 2021 for allogeneic stem cell transplantation.
RESULTS: As a result of our study, it has been observed that there are similarities in terms of HLA A*02, HLA B*35, HLA C 04,07,12, HLA DP*02,04,11 HLA DQ*02,03,05,06, HLA DR*01,03,11,13 in Turkish and Syrian patients. High resolution HLA subgroups of the patients are shown in Tables three and four.
CONCLUSION: In allogeneic stem cell transplantation, there may be similar HLA tissue types among ethnic groups. |
| first_indexed | 2024-04-10T23:26:24Z |
| format | Article |
| id | doaj.art-7020f44406b946d0bb9b885ee7103baa |
| institution | Directory Open Access Journal |
| issn | 2072-8069 |
| language | English |
| last_indexed | 2024-04-10T23:26:24Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Iraqi Journal of Hematology |
| spelling | doaj.art-7020f44406b946d0bb9b885ee7103baa2023-01-12T12:15:23ZengWolters Kluwer Medknow PublicationsIraqi Journal of Hematology2072-80692022-01-0111211011710.4103/ijh.ijh_21_22The frequency of HLA A, B, C, DP, DQ, DR allele in patients of Turkish and Syrian nationals with allogeneic stem cell transplantationAhmet KayaMehmet Ali Erkurtİrfan KukuEmin Kayaİlhami BerberSoykan BiçimEmine HidayetFatma Hilal YağinAhmet SarıcıBACKGROUND: In allogeneic stem cell transplantation, donor and recipient HLA tissue compatibility is essential for the success of stem cell transplantation. HLA tissue compatibility percentage is the most important parameter that increases the success of transplantation in donor selection. Pretransplant HLA tissue typing can be looked at in low and high resolution according to the facilities of the center and the urgency of transplantation. Many centers evaluate HLA HLA-A, B, C, DP, DQ, DR tissue types before allogeneic bone marrow transplantation. HLA tissue types differ in many races and even between unrelated individuals of the same race. AIMS: This study aimed to show the common human leukocyte antigen (HLA) rates and differences in Syrian and Turkish ethnicity patients who underwent allogeneic stem cell transplantation in our center. MATERIALS AND METHODS: HLA tissue similarities between Turkish and Syrian patients were revealed by examining the HLA tissue records of Turkish and Syrian patients who applied to the bone marrow transplant unit of Inonu University Turgut Ozal Medical Center between December 2009 and November 2021 for allogeneic stem cell transplantation. RESULTS: As a result of our study, it has been observed that there are similarities in terms of HLA A*02, HLA B*35, HLA C 04,07,12, HLA DP*02,04,11 HLA DQ*02,03,05,06, HLA DR*01,03,11,13 in Turkish and Syrian patients. High resolution HLA subgroups of the patients are shown in Tables three and four. CONCLUSION: In allogeneic stem cell transplantation, there may be similar HLA tissue types among ethnic groups.http://www.ijhonline.org/article.asp?issn=2072-8069;year=2022;volume=11;issue=2;spage=110;epage=117;aulast=Kayaallogeneic stem cell transplantationethnicityhuman leukocyte antigen tissue types |
| spellingShingle | Ahmet Kaya Mehmet Ali Erkurt İrfan Kuku Emin Kaya İlhami Berber Soykan Biçim Emine Hidayet Fatma Hilal Yağin Ahmet Sarıcı The frequency of HLA A, B, C, DP, DQ, DR allele in patients of Turkish and Syrian nationals with allogeneic stem cell transplantation Iraqi Journal of Hematology allogeneic stem cell transplantation ethnicity human leukocyte antigen tissue types |
| title | The frequency of HLA A, B, C, DP, DQ, DR allele in patients of Turkish and Syrian nationals with allogeneic stem cell transplantation |
| title_full | The frequency of HLA A, B, C, DP, DQ, DR allele in patients of Turkish and Syrian nationals with allogeneic stem cell transplantation |
| title_fullStr | The frequency of HLA A, B, C, DP, DQ, DR allele in patients of Turkish and Syrian nationals with allogeneic stem cell transplantation |
| title_full_unstemmed | The frequency of HLA A, B, C, DP, DQ, DR allele in patients of Turkish and Syrian nationals with allogeneic stem cell transplantation |
| title_short | The frequency of HLA A, B, C, DP, DQ, DR allele in patients of Turkish and Syrian nationals with allogeneic stem cell transplantation |
| title_sort | frequency of hla a b c dp dq dr allele in patients of turkish and syrian nationals with allogeneic stem cell transplantation |
| topic | allogeneic stem cell transplantation ethnicity human leukocyte antigen tissue types |
| url | http://www.ijhonline.org/article.asp?issn=2072-8069;year=2022;volume=11;issue=2;spage=110;epage=117;aulast=Kaya |
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