HLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemia
<p>Abstract</p> <p>Background</p> <p>Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for severe aplastic anemia (SAA). However, graft failure and graft-versus-host disease (GVHD) are major causes of the early morbidity in Allo-HS...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-12-01
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| Series: | Journal of Hematology & Oncology |
| Online Access: | http://www.jhoonline.org/content/3/1/51 |
| _version_ | 1818645588969783296 |
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| author | Bo-lin Tang Hui-Zhi Yang Yong-Sheng Han Kai-Yang Ding Xin Liu Wen Yao Xin-Bing Wang Liang-Quan Geng Hui-Lan Liu Zi-Min Sun Juan Tong Wei-Bo Zhu Zu-Yi Wang |
| author_facet | Bo-lin Tang Hui-Zhi Yang Yong-Sheng Han Kai-Yang Ding Xin Liu Wen Yao Xin-Bing Wang Liang-Quan Geng Hui-Lan Liu Zi-Min Sun Juan Tong Wei-Bo Zhu Zu-Yi Wang |
| author_sort | Bo-lin Tang |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for severe aplastic anemia (SAA). However, graft failure and graft-versus-host disease (GVHD) are major causes of the early morbidity in Allo-HSCT.</p> <p>Methods</p> <p>To reduce graft failure and GVHD, we treated fifteen patients with SAA using high- dose of HSCT with both G-CSF mobilized PB and BMSCs from HLA-identical siblings to treat patients with SAA.</p> <p>Results</p> <p>All patients had successful bone marrow engraftment. Only one patient had late rejection. Median time to ANC greater than 0.5 × 10<sup>9</sup>/L and platelet counts greater than 20 × 10<sup>9</sup>/L was 12 and 16.5 days, respectively. No acute GVHD was observed. The incidence of chronic GVHD was 6.67%. The total three-year probability of disease-free survival was 79.8%.</p> <p>Conclusion</p> <p>HSCT with both G-CSF mobilized PB and BMSCs is a promising approach for heavily transfused and/or allo-immunized patients with SAA.</p> |
| first_indexed | 2024-12-17T00:33:08Z |
| format | Article |
| id | doaj.art-7022e9ed840149bc803ce903d7a581f3 |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-17T00:33:08Z |
| publishDate | 2010-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-7022e9ed840149bc803ce903d7a581f32022-12-21T22:10:13ZengBMCJournal of Hematology & Oncology1756-87222010-12-01315110.1186/1756-8722-3-51HLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemiaBo-lin TangHui-Zhi YangYong-Sheng HanKai-Yang DingXin LiuWen YaoXin-Bing WangLiang-Quan GengHui-Lan LiuZi-Min SunJuan TongWei-Bo ZhuZu-Yi Wang<p>Abstract</p> <p>Background</p> <p>Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for severe aplastic anemia (SAA). However, graft failure and graft-versus-host disease (GVHD) are major causes of the early morbidity in Allo-HSCT.</p> <p>Methods</p> <p>To reduce graft failure and GVHD, we treated fifteen patients with SAA using high- dose of HSCT with both G-CSF mobilized PB and BMSCs from HLA-identical siblings to treat patients with SAA.</p> <p>Results</p> <p>All patients had successful bone marrow engraftment. Only one patient had late rejection. Median time to ANC greater than 0.5 × 10<sup>9</sup>/L and platelet counts greater than 20 × 10<sup>9</sup>/L was 12 and 16.5 days, respectively. No acute GVHD was observed. The incidence of chronic GVHD was 6.67%. The total three-year probability of disease-free survival was 79.8%.</p> <p>Conclusion</p> <p>HSCT with both G-CSF mobilized PB and BMSCs is a promising approach for heavily transfused and/or allo-immunized patients with SAA.</p>http://www.jhoonline.org/content/3/1/51 |
| spellingShingle | Bo-lin Tang Hui-Zhi Yang Yong-Sheng Han Kai-Yang Ding Xin Liu Wen Yao Xin-Bing Wang Liang-Quan Geng Hui-Lan Liu Zi-Min Sun Juan Tong Wei-Bo Zhu Zu-Yi Wang HLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemia Journal of Hematology & Oncology |
| title | HLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemia |
| title_full | HLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemia |
| title_fullStr | HLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemia |
| title_full_unstemmed | HLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemia |
| title_short | HLA-matched sibling transplantation with G-CSF mobilized PBSCs and BM decreases GVHD in adult patients with severe aplastic anemia |
| title_sort | hla matched sibling transplantation with g csf mobilized pbscs and bm decreases gvhd in adult patients with severe aplastic anemia |
| url | http://www.jhoonline.org/content/3/1/51 |
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