Circular RNAs regulate parental gene expression: A new direction for molecular oncology research
CircRNAs have been the focus of research in recent years. They are differentially expressed in various human tumors and can regulate oncogenes and tumor suppressor genes expression through various mechanisms. The diversity, stability, evolutionary conservatism and cell- or tissue-specific expression...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.947775/full |
| _version_ | 1817998248235761664 |
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| author | Haicun Wang Xin Gao Shaobo Yu Weina Wang Guanglin Liu Xingming Jiang Dongsheng Sun |
| author_facet | Haicun Wang Xin Gao Shaobo Yu Weina Wang Guanglin Liu Xingming Jiang Dongsheng Sun |
| author_sort | Haicun Wang |
| collection | DOAJ |
| description | CircRNAs have been the focus of research in recent years. They are differentially expressed in various human tumors and can regulate oncogenes and tumor suppressor genes expression through various mechanisms. The diversity, stability, evolutionary conservatism and cell- or tissue-specific expression patterns of circRNAs also endow them with important regulatory roles in promoting or inhibiting tumor cells malignant biological behaviors progression. More interestingly, emerging studies also found that circRNAs can regulate not only other genes expression, but also their parental gene expression and thus influence tumors development. Apart from some conventional features, circRNAs have a certain specificity in the regulation of parental gene expression, with a higher proportion affecting parental gene transcription and easier translation into protein to regulate parental gene expression. CircRNAs are generally thought to be unable to produce proteins and therefore the protein-coding ability exhibited by circRNAs in regulating parental gene expression is unique and indicates that the regulatory effects of parental gene expression by circRNAs are not only a competitive binding relationship, but also a more complex molecular relationship between circRNAs and parental gene, which deserves further study. This review summarizes the molecular mechanisms of circRNAs regulating parental gene expression and their biological roles in tumorigenesis and development, aiming to provide new ideas for the clinical application of circRNAs in tumor-targeted therapy. |
| first_indexed | 2024-04-14T02:50:09Z |
| format | Article |
| id | doaj.art-7025932b11b94fab96a6b6ab2cdf7b79 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-14T02:50:09Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-7025932b11b94fab96a6b6ab2cdf7b792022-12-22T02:16:18ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.947775947775Circular RNAs regulate parental gene expression: A new direction for molecular oncology researchHaicun Wang0Xin Gao1Shaobo Yu2Weina Wang3Guanglin Liu4Xingming Jiang5Dongsheng Sun6General Surgery Department, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, ChinaGeneral Surgery Department, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, ChinaGeneral Surgery Department, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Anesthesiology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, ChinaGeneral Surgery Department, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, ChinaGeneral Surgery Department, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, ChinaGeneral Surgery Department, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, ChinaCircRNAs have been the focus of research in recent years. They are differentially expressed in various human tumors and can regulate oncogenes and tumor suppressor genes expression through various mechanisms. The diversity, stability, evolutionary conservatism and cell- or tissue-specific expression patterns of circRNAs also endow them with important regulatory roles in promoting or inhibiting tumor cells malignant biological behaviors progression. More interestingly, emerging studies also found that circRNAs can regulate not only other genes expression, but also their parental gene expression and thus influence tumors development. Apart from some conventional features, circRNAs have a certain specificity in the regulation of parental gene expression, with a higher proportion affecting parental gene transcription and easier translation into protein to regulate parental gene expression. CircRNAs are generally thought to be unable to produce proteins and therefore the protein-coding ability exhibited by circRNAs in regulating parental gene expression is unique and indicates that the regulatory effects of parental gene expression by circRNAs are not only a competitive binding relationship, but also a more complex molecular relationship between circRNAs and parental gene, which deserves further study. This review summarizes the molecular mechanisms of circRNAs regulating parental gene expression and their biological roles in tumorigenesis and development, aiming to provide new ideas for the clinical application of circRNAs in tumor-targeted therapy.https://www.frontiersin.org/articles/10.3389/fonc.2022.947775/fullcircRNAsparental generegulatory mechanismtumorsmolecular oncology |
| spellingShingle | Haicun Wang Xin Gao Shaobo Yu Weina Wang Guanglin Liu Xingming Jiang Dongsheng Sun Circular RNAs regulate parental gene expression: A new direction for molecular oncology research Frontiers in Oncology circRNAs parental gene regulatory mechanism tumors molecular oncology |
| title | Circular RNAs regulate parental gene expression: A new direction for molecular oncology research |
| title_full | Circular RNAs regulate parental gene expression: A new direction for molecular oncology research |
| title_fullStr | Circular RNAs regulate parental gene expression: A new direction for molecular oncology research |
| title_full_unstemmed | Circular RNAs regulate parental gene expression: A new direction for molecular oncology research |
| title_short | Circular RNAs regulate parental gene expression: A new direction for molecular oncology research |
| title_sort | circular rnas regulate parental gene expression a new direction for molecular oncology research |
| topic | circRNAs parental gene regulatory mechanism tumors molecular oncology |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.947775/full |
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