Oncogenic activation revealed by FGFR2 genetic alterations in intrahepatic cholangiocarcinomas

Oncogenic activation revealed by FGFR2 genetic alterations in intrahepatic cholangiocarcinomas

Abstract Background Except for gene fusions, FGFR2 genetic alterations in intrahepatic cholangiocarcinomas (ICCs) have received limited attention, leaving patients harboring activating FGFR2 gene mutations with inadequate access to targeted therapies. Experimental design We sought to survey FGFR2 ge...

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Bibliographic Details
Main Authors: Xiaohong Pu, Liang Qi, Jia Wu Yan, Zihe Ai, Ping Wu, Fei Yang, Yao Fu, Xing Li, Min Zhang, Beicheng Sun, Shen Yue, Jun Chen
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cell & Bioscience
Subjects:
Intrahepatic cholangiocarcinoma
FGFR2
Translocation
In-frame deletion
Online Access:https://doi.org/10.1186/s13578-023-01156-7

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