Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis.

Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis.

Reprogramming metabolism is of great therapeutic interest for reducing morbidity and mortality during sepsis-induced critical illness. Disappointing results from randomized controlled trials targeting glutamine and antioxidant metabolism in patients with sepsis have begged a deeper understanding of...

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Bibliographic Details
Main Authors: Brooks P Leitner, Won D Lee, Wanling Zhu, Xinyi Zhang, Rafael C Gaspar, Zongyu Li, Joshua D Rabinowitz, Rachel J Perry
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0286525

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