Cord Blood Theophylline Levels and Respiratory Morbidities In Preterm Infants
Objective: to investigate whether there is any relationship between cord blood theophylline levels and pulmonary morbidities in the early neonatal period in premature infants. Study Design: This prospective cohort study was conducted in Hacettepe University Hospital Neonatology Unit, between Novemb...
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| Format: | Article |
| Language: | English |
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Medical Network
2019-08-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
| Subjects: | |
| Online Access: | http://gorm.com.tr/index.php/GORM/article/view/856 |
| _version_ | 1797920431242477568 |
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| author | Tolga Hasan Celik Ayse Korkmaz Sule Yigit Murat Yurdakok |
| author_facet | Tolga Hasan Celik Ayse Korkmaz Sule Yigit Murat Yurdakok |
| author_sort | Tolga Hasan Celik |
| collection | DOAJ |
| description | Objective: to investigate whether there is any relationship between cord blood theophylline levels and pulmonary morbidities in the early neonatal period in premature infants.
Study Design: This prospective cohort study was conducted in Hacettepe University Hospital Neonatology Unit, between November 2010 and January 2012. Cord blood samples were collected at birth from premature infants, and theophylline levels were measured. Theophylline levels of cord blood were compared between infants with and without pulmonary morbidity.
Results: A total of 90 infants (42 females, 48 males) were enrolled in the study. The mean gestational age was 31.1±3.1 weeks, and the mean birth weight was 1527±540 g. Early respiratory morbidities developed in 57 infants (63.3%), while no respiratory morbidities were observed in 33 infants (36.7%). There was no significant difference between the groups in blood gas parameters, oxygen saturation values and cord blood theophylline levels.
Conclusions: Although the theophylline levels that were measured in the cord blood were much lower than therapeutic serum levels, we concluded that the cord theophylline level is not valuable as a prognostic factor for pulmonary morbidities in premature newborns. |
| first_indexed | 2024-04-10T14:01:05Z |
| format | Article |
| id | doaj.art-7027653bf2be4bc4b305fd40ebaa1d09 |
| institution | Directory Open Access Journal |
| issn | 1300-4751 |
| language | English |
| last_indexed | 2024-04-10T14:01:05Z |
| publishDate | 2019-08-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj.art-7027653bf2be4bc4b305fd40ebaa1d092023-02-15T16:10:15ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512019-08-0125211211610.21613/GORM.2018.856664Cord Blood Theophylline Levels and Respiratory Morbidities In Preterm InfantsTolga Hasan Celik0Ayse Korkmaz1Sule Yigit2Murat YurdakokHacettepe University Faculty of Medicine Department of Paediatrics Division of NeonatologyHacettepe University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Ankara, Turkey.Objective: to investigate whether there is any relationship between cord blood theophylline levels and pulmonary morbidities in the early neonatal period in premature infants. Study Design: This prospective cohort study was conducted in Hacettepe University Hospital Neonatology Unit, between November 2010 and January 2012. Cord blood samples were collected at birth from premature infants, and theophylline levels were measured. Theophylline levels of cord blood were compared between infants with and without pulmonary morbidity. Results: A total of 90 infants (42 females, 48 males) were enrolled in the study. The mean gestational age was 31.1±3.1 weeks, and the mean birth weight was 1527±540 g. Early respiratory morbidities developed in 57 infants (63.3%), while no respiratory morbidities were observed in 33 infants (36.7%). There was no significant difference between the groups in blood gas parameters, oxygen saturation values and cord blood theophylline levels. Conclusions: Although the theophylline levels that were measured in the cord blood were much lower than therapeutic serum levels, we concluded that the cord theophylline level is not valuable as a prognostic factor for pulmonary morbidities in premature newborns.http://gorm.com.tr/index.php/GORM/article/view/856newborn, neonate, premature, cord blood theophylline, caffeine, respiratory morbidities |
| spellingShingle | Tolga Hasan Celik Ayse Korkmaz Sule Yigit Murat Yurdakok Cord Blood Theophylline Levels and Respiratory Morbidities In Preterm Infants Gynecology Obstetrics & Reproductive Medicine newborn, neonate, premature, cord blood theophylline, caffeine, respiratory morbidities |
| title | Cord Blood Theophylline Levels and Respiratory Morbidities In Preterm Infants |
| title_full | Cord Blood Theophylline Levels and Respiratory Morbidities In Preterm Infants |
| title_fullStr | Cord Blood Theophylline Levels and Respiratory Morbidities In Preterm Infants |
| title_full_unstemmed | Cord Blood Theophylline Levels and Respiratory Morbidities In Preterm Infants |
| title_short | Cord Blood Theophylline Levels and Respiratory Morbidities In Preterm Infants |
| title_sort | cord blood theophylline levels and respiratory morbidities in preterm infants |
| topic | newborn, neonate, premature, cord blood theophylline, caffeine, respiratory morbidities |
| url | http://gorm.com.tr/index.php/GORM/article/view/856 |
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