Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer?
Pancreatic cancer is a very aggressive cancer type associated with one of the poorest prognostics. Despite several clinical trials to combine different types of therapies, none of them resulted in significant improvements for patient survival. Pancreatic cancers demonstrate a very broad panel of res...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-07-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/13/4767 |
| _version_ | 1797563291621392384 |
|---|---|
| author | Camille Huart Jia-Wei Chen Benjamin Le Calvé Carine Michiels Anne-Catherine Wéra |
| author_facet | Camille Huart Jia-Wei Chen Benjamin Le Calvé Carine Michiels Anne-Catherine Wéra |
| author_sort | Camille Huart |
| collection | DOAJ |
| description | Pancreatic cancer is a very aggressive cancer type associated with one of the poorest prognostics. Despite several clinical trials to combine different types of therapies, none of them resulted in significant improvements for patient survival. Pancreatic cancers demonstrate a very broad panel of resistance mechanisms due to their biological properties but also their ability to remodel the tumour microenvironment. Radiotherapy is one of the most widely used treatments against cancer but, up to now, its impact remains limited in the context of pancreatic cancer. The modern era of radiotherapy proposes new approaches with increasing conformation but also more efficient effects on tumours in the case of charged particles. In this review, we highlight the interest in using charged particles in the context of pancreatic cancer therapy and the impact of this alternative to counteract resistance mechanisms. |
| first_indexed | 2024-03-10T18:40:34Z |
| format | Article |
| id | doaj.art-702823e4b6134191aa7e9448d73abf7a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:40:34Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-702823e4b6134191aa7e9448d73abf7a2023-11-20T05:52:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012113476710.3390/ijms21134767Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer?Camille Huart0Jia-Wei Chen1Benjamin Le Calvé2Carine Michiels3Anne-Catherine Wéra4Unité de Recherche en Biologie Cellulaire (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000 Namur, BelgiumUnité de Recherche en Biologie Cellulaire (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000 Namur, BelgiumUnité de Recherche en Biologie Cellulaire (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000 Namur, BelgiumUnité de Recherche en Biologie Cellulaire (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000 Namur, BelgiumUnité de Recherche en Biologie Cellulaire (URBC), Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000 Namur, BelgiumPancreatic cancer is a very aggressive cancer type associated with one of the poorest prognostics. Despite several clinical trials to combine different types of therapies, none of them resulted in significant improvements for patient survival. Pancreatic cancers demonstrate a very broad panel of resistance mechanisms due to their biological properties but also their ability to remodel the tumour microenvironment. Radiotherapy is one of the most widely used treatments against cancer but, up to now, its impact remains limited in the context of pancreatic cancer. The modern era of radiotherapy proposes new approaches with increasing conformation but also more efficient effects on tumours in the case of charged particles. In this review, we highlight the interest in using charged particles in the context of pancreatic cancer therapy and the impact of this alternative to counteract resistance mechanisms.https://www.mdpi.com/1422-0067/21/13/4767pancreatic cancerprotonscarbon ionsradioresistancechemoresistancetargeted combination |
| spellingShingle | Camille Huart Jia-Wei Chen Benjamin Le Calvé Carine Michiels Anne-Catherine Wéra Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer? International Journal of Molecular Sciences pancreatic cancer protons carbon ions radioresistance chemoresistance targeted combination |
| title | Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer? |
| title_full | Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer? |
| title_fullStr | Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer? |
| title_full_unstemmed | Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer? |
| title_short | Could Protons and Carbon Ions Be the Silver Bullets Against Pancreatic Cancer? |
| title_sort | could protons and carbon ions be the silver bullets against pancreatic cancer |
| topic | pancreatic cancer protons carbon ions radioresistance chemoresistance targeted combination |
| url | https://www.mdpi.com/1422-0067/21/13/4767 |
| work_keys_str_mv | AT camillehuart couldprotonsandcarbonionsbethesilverbulletsagainstpancreaticcancer AT jiaweichen couldprotonsandcarbonionsbethesilverbulletsagainstpancreaticcancer AT benjaminlecalve couldprotonsandcarbonionsbethesilverbulletsagainstpancreaticcancer AT carinemichiels couldprotonsandcarbonionsbethesilverbulletsagainstpancreaticcancer AT annecatherinewera couldprotonsandcarbonionsbethesilverbulletsagainstpancreaticcancer |