Automated Image Analysis of Transmission Electron Micrographs: Nanoscale Evaluation of Radiation-Induced DNA Damage in the Context of Chromatin

Background: Heavy ion irradiation (IR) with high-linear energy transfer (LET) is characterized by a unique depth dose distribution and increased biological effectiveness. Following high-LET IR, localized energy deposition along the particle trajectories induces clustered DNA lesions, leading to low...

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Bibliographic Details
Main Authors: Mutaz A. Abd Al-razaq, Anna Isermann, Markus Hecht, Claudia E. Rübe
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/12/20/2427