HYDRHA: Hydrogels of hyaluronic acid. New biomedical approaches in cancer, neurodegenerative diseases, and tissue engineering
In the last decade, hyaluronic acid (HA) has attracted an ever-growing interest in the biomedical engineering field as a biocompatible, biodegradable, and chemically versatile molecule. In fact, HA is a major component of the extracellular matrix (ECM) and is essential for the maintenance of cellula...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
|
| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422002514 |
| _version_ | 1811241639065157632 |
|---|---|
| author | Maddalena Grieco Ornella Ursini Ilaria Elena Palamà Giuseppe Gigli Lorenzo Moroni Barbara Cortese |
| author_facet | Maddalena Grieco Ornella Ursini Ilaria Elena Palamà Giuseppe Gigli Lorenzo Moroni Barbara Cortese |
| author_sort | Maddalena Grieco |
| collection | DOAJ |
| description | In the last decade, hyaluronic acid (HA) has attracted an ever-growing interest in the biomedical engineering field as a biocompatible, biodegradable, and chemically versatile molecule. In fact, HA is a major component of the extracellular matrix (ECM) and is essential for the maintenance of cellular homeostasis and crosstalk. Innovative experimental strategies in vitro and in vivo using three-dimensional (3D) HA systems have been increasingly reported in studies of diseases, replacement of tissue and organ damage, repairing wounds, and encapsulating stem cells for tissue regeneration. The present work aims to give an overview and comparison of recent work carried out on HA systems showing advantages, limitations, and their complementarity, for a comprehensive characterization of their use. A special attention is paid to the use of HA in three important areas: cancer, diseases of the central nervous system (CNS), and tissue regeneration, discussing the most innovative experimental strategies. Finally, perspectives within and beyond these research fields are discussed. |
| first_indexed | 2024-04-12T13:38:59Z |
| format | Article |
| id | doaj.art-702987f6473348a7a2a0f256be13560c |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-12T13:38:59Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-702987f6473348a7a2a0f256be13560c2022-12-22T03:30:53ZengElsevierMaterials Today Bio2590-00642022-12-0117100453HYDRHA: Hydrogels of hyaluronic acid. New biomedical approaches in cancer, neurodegenerative diseases, and tissue engineeringMaddalena Grieco0Ornella Ursini1Ilaria Elena Palamà2Giuseppe Gigli3Lorenzo Moroni4Barbara Cortese5National Research Council-Nanotechnology Institute (CNR Nanotec), 73100, Lecce, ItalyNational Research Council-Nanotechnology Institute (CNR Nanotec), 00185, Rome, ItalyNational Research Council-Nanotechnology Institute (CNR Nanotec), 73100, Lecce, ItalyNational Research Council-Nanotechnology Institute (CNR Nanotec), 73100, Lecce, Italy; Department of Mathematics and Physics “Ennio De Giorgi” University of Salento, Via Arnesano, 73100, Lecce, ItalyNational Research Council-Nanotechnology Institute (CNR Nanotec), 73100, Lecce, Italy; Complex Tissue Regeneration Department, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Universiteitssingel 40, Maastricht, 6229 ER, the NetherlandsNational Research Council-Nanotechnology Institute (CNR Nanotec), 00185, Rome, Italy; Corresponding author.In the last decade, hyaluronic acid (HA) has attracted an ever-growing interest in the biomedical engineering field as a biocompatible, biodegradable, and chemically versatile molecule. In fact, HA is a major component of the extracellular matrix (ECM) and is essential for the maintenance of cellular homeostasis and crosstalk. Innovative experimental strategies in vitro and in vivo using three-dimensional (3D) HA systems have been increasingly reported in studies of diseases, replacement of tissue and organ damage, repairing wounds, and encapsulating stem cells for tissue regeneration. The present work aims to give an overview and comparison of recent work carried out on HA systems showing advantages, limitations, and their complementarity, for a comprehensive characterization of their use. A special attention is paid to the use of HA in three important areas: cancer, diseases of the central nervous system (CNS), and tissue regeneration, discussing the most innovative experimental strategies. Finally, perspectives within and beyond these research fields are discussed.http://www.sciencedirect.com/science/article/pii/S2590006422002514Hyaluronic acidHydrogelBiomaterialTissue engineeringCancerCentral nervous system |
| spellingShingle | Maddalena Grieco Ornella Ursini Ilaria Elena Palamà Giuseppe Gigli Lorenzo Moroni Barbara Cortese HYDRHA: Hydrogels of hyaluronic acid. New biomedical approaches in cancer, neurodegenerative diseases, and tissue engineering Materials Today Bio Hyaluronic acid Hydrogel Biomaterial Tissue engineering Cancer Central nervous system |
| title | HYDRHA: Hydrogels of hyaluronic acid. New biomedical approaches in cancer, neurodegenerative diseases, and tissue engineering |
| title_full | HYDRHA: Hydrogels of hyaluronic acid. New biomedical approaches in cancer, neurodegenerative diseases, and tissue engineering |
| title_fullStr | HYDRHA: Hydrogels of hyaluronic acid. New biomedical approaches in cancer, neurodegenerative diseases, and tissue engineering |
| title_full_unstemmed | HYDRHA: Hydrogels of hyaluronic acid. New biomedical approaches in cancer, neurodegenerative diseases, and tissue engineering |
| title_short | HYDRHA: Hydrogels of hyaluronic acid. New biomedical approaches in cancer, neurodegenerative diseases, and tissue engineering |
| title_sort | hydrha hydrogels of hyaluronic acid new biomedical approaches in cancer neurodegenerative diseases and tissue engineering |
| topic | Hyaluronic acid Hydrogel Biomaterial Tissue engineering Cancer Central nervous system |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422002514 |
| work_keys_str_mv | AT maddalenagrieco hydrhahydrogelsofhyaluronicacidnewbiomedicalapproachesincancerneurodegenerativediseasesandtissueengineering AT ornellaursini hydrhahydrogelsofhyaluronicacidnewbiomedicalapproachesincancerneurodegenerativediseasesandtissueengineering AT ilariaelenapalama hydrhahydrogelsofhyaluronicacidnewbiomedicalapproachesincancerneurodegenerativediseasesandtissueengineering AT giuseppegigli hydrhahydrogelsofhyaluronicacidnewbiomedicalapproachesincancerneurodegenerativediseasesandtissueengineering AT lorenzomoroni hydrhahydrogelsofhyaluronicacidnewbiomedicalapproachesincancerneurodegenerativediseasesandtissueengineering AT barbaracortese hydrhahydrogelsofhyaluronicacidnewbiomedicalapproachesincancerneurodegenerativediseasesandtissueengineering |