Genetic Imaging of the Association of Oxytocin Receptor Gene (OXTR) Polymorphisms with Positive Maternal Parenting
Background: Well-validated models of maternal behavior in small-brain mammals posit a central role of oxytocin in parenting, by reducing stress and enhancing the reward value of social interactions with offspring. In contrast, human studies are only beginning to gain insights into how oxytocin modul...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-02-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00021/full |
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| author | Kalina J. Michalska Kalina J. Michalska Kalina J. Michalska Jean eDecety Jean eDecety Chunyu eLiu Qi eChen Meghan Elizabeth Martz Suma eJacob Alison eHipwell Steve S Lee Andrea eChronis-Tuscano Irwin D Waldman Benjamin B. Lahey |
| author_facet | Kalina J. Michalska Kalina J. Michalska Kalina J. Michalska Jean eDecety Jean eDecety Chunyu eLiu Qi eChen Meghan Elizabeth Martz Suma eJacob Alison eHipwell Steve S Lee Andrea eChronis-Tuscano Irwin D Waldman Benjamin B. Lahey |
| author_sort | Kalina J. Michalska |
| collection | DOAJ |
| description | Background: Well-validated models of maternal behavior in small-brain mammals posit a central role of oxytocin in parenting, by reducing stress and enhancing the reward value of social interactions with offspring. In contrast, human studies are only beginning to gain insights into how oxytocin modulates maternal behavior and affiliation. Methods: To explore associations between oxytocin receptor genes and maternal parenting behavior in humans, we conducted a genetic imaging study of women selected to exhibit a wide range of observed parenting when their children were 4-6 years old. Results: In response to child stimuli during functional magnetic resonance imaging, hemodynamic responses in brain regions that mediate affect, reward, and social behavior were significantly correlated with observed positive parenting. Furthermore, single nucleotide polymorphisms (rs53576 and rs1042778) in the gene encoding the oxytocin receptor were significantly associated with both positive parenting and hemodynamic responses to child stimuli in orbitofrontal cortex, anterior cingulate cortex and hippocampus. Conclusions: These findings contribute to the emerging literature on the role of oxytocin in human social behavior and support the feasibility of tracing biological pathways from genes to neural regions to positive maternal parenting behaviors in humans using genetic imaging methods. |
| first_indexed | 2024-04-13T08:22:33Z |
| format | Article |
| id | doaj.art-702aa88d056c44ed9f5743cd3f32f025 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-13T08:22:33Z |
| publishDate | 2014-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-702aa88d056c44ed9f5743cd3f32f0252022-12-22T02:54:37ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532014-02-01810.3389/fnbeh.2014.0002166588Genetic Imaging of the Association of Oxytocin Receptor Gene (OXTR) Polymorphisms with Positive Maternal ParentingKalina J. Michalska0Kalina J. Michalska1Kalina J. Michalska2Jean eDecety3Jean eDecety4Chunyu eLiu5Qi eChen6Meghan Elizabeth Martz7Suma eJacob8Alison eHipwell9Steve S Lee10Andrea eChronis-Tuscano11Irwin D Waldman12Benjamin B. Lahey13National Institute of Mental HealthThe University of ChicagoUniversity of Maryland, College ParkThe University of ChicagoUniversity of ChicagoUniversity of Illinois at ChicagoChildren's Hospital of Chicago Research CenterUniversity of MichiganUniversity of MinnesotaUniversity of PittsburghUCLAUniversity of Maryland, College ParkEmory UniversityThe University of ChicagoBackground: Well-validated models of maternal behavior in small-brain mammals posit a central role of oxytocin in parenting, by reducing stress and enhancing the reward value of social interactions with offspring. In contrast, human studies are only beginning to gain insights into how oxytocin modulates maternal behavior and affiliation. Methods: To explore associations between oxytocin receptor genes and maternal parenting behavior in humans, we conducted a genetic imaging study of women selected to exhibit a wide range of observed parenting when their children were 4-6 years old. Results: In response to child stimuli during functional magnetic resonance imaging, hemodynamic responses in brain regions that mediate affect, reward, and social behavior were significantly correlated with observed positive parenting. Furthermore, single nucleotide polymorphisms (rs53576 and rs1042778) in the gene encoding the oxytocin receptor were significantly associated with both positive parenting and hemodynamic responses to child stimuli in orbitofrontal cortex, anterior cingulate cortex and hippocampus. Conclusions: These findings contribute to the emerging literature on the role of oxytocin in human social behavior and support the feasibility of tracing biological pathways from genes to neural regions to positive maternal parenting behaviors in humans using genetic imaging methods.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00021/fullfMRIOXTRoxytocin receptor geneGenetic ImagingMaternal parenting |
| spellingShingle | Kalina J. Michalska Kalina J. Michalska Kalina J. Michalska Jean eDecety Jean eDecety Chunyu eLiu Qi eChen Meghan Elizabeth Martz Suma eJacob Alison eHipwell Steve S Lee Andrea eChronis-Tuscano Irwin D Waldman Benjamin B. Lahey Genetic Imaging of the Association of Oxytocin Receptor Gene (OXTR) Polymorphisms with Positive Maternal Parenting Frontiers in Behavioral Neuroscience fMRI OXTR oxytocin receptor gene Genetic Imaging Maternal parenting |
| title | Genetic Imaging of the Association of Oxytocin Receptor Gene (OXTR) Polymorphisms with Positive Maternal Parenting |
| title_full | Genetic Imaging of the Association of Oxytocin Receptor Gene (OXTR) Polymorphisms with Positive Maternal Parenting |
| title_fullStr | Genetic Imaging of the Association of Oxytocin Receptor Gene (OXTR) Polymorphisms with Positive Maternal Parenting |
| title_full_unstemmed | Genetic Imaging of the Association of Oxytocin Receptor Gene (OXTR) Polymorphisms with Positive Maternal Parenting |
| title_short | Genetic Imaging of the Association of Oxytocin Receptor Gene (OXTR) Polymorphisms with Positive Maternal Parenting |
| title_sort | genetic imaging of the association of oxytocin receptor gene oxtr polymorphisms with positive maternal parenting |
| topic | fMRI OXTR oxytocin receptor gene Genetic Imaging Maternal parenting |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00021/full |
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