Challenges in the diagnosis of pulmonary mucormycosis in a diabetic with a review of literature
Diabetes Mellitus appears to be the most common underlying condition associated with mucormycosis; a rare opportunistic fungal infection associated with high morbidity and mortality. Pulmonary mucormycosis may mimic pneumonia and thus pose challenges in achieving a timely diagnosis critical to succe...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007121001362 |
| _version_ | 1830355946541416448 |
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| author | Muhammad Yousaf Sarah Salameh Irfan Ul Haq Samir Alhyassat Merlin Thomas Aisha Hussain Mohd Wani Ehab Massad Hamad Abdel Hadi Hisham Abdul Sattar Mansoor Hameed |
| author_facet | Muhammad Yousaf Sarah Salameh Irfan Ul Haq Samir Alhyassat Merlin Thomas Aisha Hussain Mohd Wani Ehab Massad Hamad Abdel Hadi Hisham Abdul Sattar Mansoor Hameed |
| author_sort | Muhammad Yousaf |
| collection | DOAJ |
| description | Diabetes Mellitus appears to be the most common underlying condition associated with mucormycosis; a rare opportunistic fungal infection associated with high morbidity and mortality. Pulmonary mucormycosis may mimic pneumonia and thus pose challenges in achieving a timely diagnosis critical to successful outcomes. We present a case of a 65-year-old diabetic who presented with fever and haemoptysis that was managed as pneumonia. A bronchial alveolar lavage grew Rhizopus mould that was thought to be a contaminant as he responded well to antibiotics. He required another admission in 4 weeks due to worsening symptoms. Failure to respond to antibiotics and ongoing clinical and radiological deterioration led to a lobectomy that confirmed a diagnosis of pulmonary mucormycosis. He responded well to surgical resection and antifungal therapy with a complete recovery. Elusive clinical presentation and insensitive conventional diagnostic techniques may make the diagnosis of mucormycosis challenging. Our case reports highlight the issues involved in the diagnosis and management of pulmonary Mucormycosis mimicking as pneumonia. |
| first_indexed | 2024-12-20T01:56:51Z |
| format | Article |
| id | doaj.art-702b1a216ee14d9c99430c343d2baaab |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-20T01:56:51Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-702b1a216ee14d9c99430c343d2baaab2022-12-21T19:57:27ZengElsevierRespiratory Medicine Case Reports2213-00712021-01-0133101474Challenges in the diagnosis of pulmonary mucormycosis in a diabetic with a review of literatureMuhammad Yousaf0Sarah Salameh1Irfan Ul Haq2Samir Alhyassat3Merlin Thomas4Aisha Hussain5Mohd Wani6Ehab Massad7Hamad Abdel Hadi8Hisham Abdul Sattar9Mansoor Hameed10Hazm Mebaireek Hospital, Hamad Medical Corporation, Doha, Qatar; Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar; Corresponding author. Hazm Mebaireek Hospital, Hamad Medical Corporation, Doha, Qatar.Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar; Communicable Diseases Centre, Hamad Medical Corporation, QatarHamad General Hospital, Hamad Medical Corporation, Doha, Qatar; Weill Cornell Medicine-Qatar, Cornell University, Doha, QatarDepartment of Laboratory Medicine and Pathology, Hamad Medical Corporation, QatarHamad General Hospital, Hamad Medical Corporation, Doha, Qatar; Weill Cornell Medicine-Qatar, Cornell University, Doha, QatarHamad General Hospital, Hamad Medical Corporation, Doha, QatarDepartment of Cardiothoracic Surgery, Hamad Medical Corporation, QatarDepartment of Cardiothoracic Surgery, Hamad Medical Corporation, QatarCommunicable Diseases Centre, Hamad Medical Corporation, QatarHamad General Hospital, Hamad Medical Corporation, Doha, QatarHamad General Hospital, Hamad Medical Corporation, Doha, Qatar; Weill Cornell Medicine-Qatar, Cornell University, Doha, QatarDiabetes Mellitus appears to be the most common underlying condition associated with mucormycosis; a rare opportunistic fungal infection associated with high morbidity and mortality. Pulmonary mucormycosis may mimic pneumonia and thus pose challenges in achieving a timely diagnosis critical to successful outcomes. We present a case of a 65-year-old diabetic who presented with fever and haemoptysis that was managed as pneumonia. A bronchial alveolar lavage grew Rhizopus mould that was thought to be a contaminant as he responded well to antibiotics. He required another admission in 4 weeks due to worsening symptoms. Failure to respond to antibiotics and ongoing clinical and radiological deterioration led to a lobectomy that confirmed a diagnosis of pulmonary mucormycosis. He responded well to surgical resection and antifungal therapy with a complete recovery. Elusive clinical presentation and insensitive conventional diagnostic techniques may make the diagnosis of mucormycosis challenging. Our case reports highlight the issues involved in the diagnosis and management of pulmonary Mucormycosis mimicking as pneumonia.http://www.sciencedirect.com/science/article/pii/S2213007121001362MucormycosisZygomycosisInvasive fungal infectionsDiabetesPneumoniaAntifungal |
| spellingShingle | Muhammad Yousaf Sarah Salameh Irfan Ul Haq Samir Alhyassat Merlin Thomas Aisha Hussain Mohd Wani Ehab Massad Hamad Abdel Hadi Hisham Abdul Sattar Mansoor Hameed Challenges in the diagnosis of pulmonary mucormycosis in a diabetic with a review of literature Respiratory Medicine Case Reports Mucormycosis Zygomycosis Invasive fungal infections Diabetes Pneumonia Antifungal |
| title | Challenges in the diagnosis of pulmonary mucormycosis in a diabetic with a review of literature |
| title_full | Challenges in the diagnosis of pulmonary mucormycosis in a diabetic with a review of literature |
| title_fullStr | Challenges in the diagnosis of pulmonary mucormycosis in a diabetic with a review of literature |
| title_full_unstemmed | Challenges in the diagnosis of pulmonary mucormycosis in a diabetic with a review of literature |
| title_short | Challenges in the diagnosis of pulmonary mucormycosis in a diabetic with a review of literature |
| title_sort | challenges in the diagnosis of pulmonary mucormycosis in a diabetic with a review of literature |
| topic | Mucormycosis Zygomycosis Invasive fungal infections Diabetes Pneumonia Antifungal |
| url | http://www.sciencedirect.com/science/article/pii/S2213007121001362 |
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