One Hour-Post-load Plasma Glucose ≥155 mg/dl in Healthy Glucose Normotolerant Subjects Is Associated With Subcortical Brain MRI Alterations and Impaired Cognition: A Pilot Study
Background: Glucose alterations are associated with impaired cognition. The 1-h-post-load plasma glucose ≥155 mg/dl in non-diabetic subjects confers an increased risk of cardiovascular events and diabetes. This pilot study aimed to investigate whether the 1-h-post-load plasma glucose ≥155 mg/dl nega...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.608736/full |
| _version_ | 1829491635551993856 |
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| author | Maria Perticone Cherubino Di Lorenzo Gennarina Arabia Franco Arturi Benedetto Caroleo Bruno Tassone Roberta Pujia Teresa Vanessa Fiorentino Carmelina Chiriaco Giorgio Sesti Aldo Quattrone Francesco Perticone |
| author_facet | Maria Perticone Cherubino Di Lorenzo Gennarina Arabia Franco Arturi Benedetto Caroleo Bruno Tassone Roberta Pujia Teresa Vanessa Fiorentino Carmelina Chiriaco Giorgio Sesti Aldo Quattrone Francesco Perticone |
| author_sort | Maria Perticone |
| collection | DOAJ |
| description | Background: Glucose alterations are associated with impaired cognition. The 1-h-post-load plasma glucose ≥155 mg/dl in non-diabetic subjects confers an increased risk of cardiovascular events and diabetes. This pilot study aimed to investigate whether the 1-h-post-load plasma glucose ≥155 mg/dl negatively affects the subcortical regions of the brain and the cognitive functions.Methods: We enrolled 32 non-diabetic subjects. Patients were divided into two groups based on 1-h- post-load plasma glucose value > or < 155 mg/dl: normal glucose tolerance (NGT) 1-h-high and NGT 1-h-low subjects. All subjects underwent 3 Tesla MRI and standard neuropsychological tests.Results: NGT 1-h-high subjects showed significantly lower values of both right (4.9 ± 0.9 vs. 5.1 ± 0.9 ml) and left (4.8 ± 1.1 vs. 5.1 ± 1.1 ml) hippocampal hemisphere volume, while right hemisphere hippocampal diffusivity was lower in the NGT 1-h-high group (10.0 ± 0.6 vs. 10.6 ± 0.5 10−4 mm2s−1). NGT 1-h-high subjects also showed a poorer memory performance. In particular, for both Rey Auditory Verbal Learning Task (RAVLT)—immediate-recall and Free and Cued Selective Reminding Test (FCSRT)—delayed total recall, we found lower cognitive test scores in the NGT-1 h-high group (26.5 ± 6.3 and 10.4 ± 0.3, respectively).Conclusions: One-hour-post-load hyperglycemia is associated with morpho-functional subcortical brain alterations and poor memory performance tests. |
| first_indexed | 2024-12-15T00:43:26Z |
| format | Article |
| id | doaj.art-702b4fe684ba4a058272e76f1c6f9707 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-15T00:43:26Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-702b4fe684ba4a058272e76f1c6f97072022-12-21T22:41:37ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-02-011310.3389/fnagi.2021.608736608736One Hour-Post-load Plasma Glucose ≥155 mg/dl in Healthy Glucose Normotolerant Subjects Is Associated With Subcortical Brain MRI Alterations and Impaired Cognition: A Pilot StudyMaria Perticone0Cherubino Di Lorenzo1Gennarina Arabia2Franco Arturi3Benedetto Caroleo4Bruno Tassone5Roberta Pujia6Teresa Vanessa Fiorentino7Carmelina Chiriaco8Giorgio Sesti9Aldo Quattrone10Francesco Perticone11Geriatrics Division, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, La Sapienza University Polo Pontino, Latina, ItalyNeurology Division, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, ItalyInternal Medicine Division, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, ItalyGeriatric Division, Azienda Ospedaliero-Universitaria Mater Domini, Catanzaro, ItalyInternal Medicine Division, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, ItalyInternal Medicine Division, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, ItalyInternal Medicine Division, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, ItalyInstitute of Molecular Bioimaging and Physiology, National Research Council, Catanzaro, ItalyDepartment of Clinical and Molecular Medicine, La Sapienza University, Rome, ItalyInstitute of Molecular Bioimaging and Physiology, National Research Council, Catanzaro, ItalyGeriatrics Division, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, ItalyBackground: Glucose alterations are associated with impaired cognition. The 1-h-post-load plasma glucose ≥155 mg/dl in non-diabetic subjects confers an increased risk of cardiovascular events and diabetes. This pilot study aimed to investigate whether the 1-h-post-load plasma glucose ≥155 mg/dl negatively affects the subcortical regions of the brain and the cognitive functions.Methods: We enrolled 32 non-diabetic subjects. Patients were divided into two groups based on 1-h- post-load plasma glucose value > or < 155 mg/dl: normal glucose tolerance (NGT) 1-h-high and NGT 1-h-low subjects. All subjects underwent 3 Tesla MRI and standard neuropsychological tests.Results: NGT 1-h-high subjects showed significantly lower values of both right (4.9 ± 0.9 vs. 5.1 ± 0.9 ml) and left (4.8 ± 1.1 vs. 5.1 ± 1.1 ml) hippocampal hemisphere volume, while right hemisphere hippocampal diffusivity was lower in the NGT 1-h-high group (10.0 ± 0.6 vs. 10.6 ± 0.5 10−4 mm2s−1). NGT 1-h-high subjects also showed a poorer memory performance. In particular, for both Rey Auditory Verbal Learning Task (RAVLT)—immediate-recall and Free and Cued Selective Reminding Test (FCSRT)—delayed total recall, we found lower cognitive test scores in the NGT-1 h-high group (26.5 ± 6.3 and 10.4 ± 0.3, respectively).Conclusions: One-hour-post-load hyperglycemia is associated with morpho-functional subcortical brain alterations and poor memory performance tests.https://www.frontiersin.org/articles/10.3389/fnagi.2021.608736/fullprediabetesmild cognitive impairmenthippocampal volumeMRImemory test |
| spellingShingle | Maria Perticone Cherubino Di Lorenzo Gennarina Arabia Franco Arturi Benedetto Caroleo Bruno Tassone Roberta Pujia Teresa Vanessa Fiorentino Carmelina Chiriaco Giorgio Sesti Aldo Quattrone Francesco Perticone One Hour-Post-load Plasma Glucose ≥155 mg/dl in Healthy Glucose Normotolerant Subjects Is Associated With Subcortical Brain MRI Alterations and Impaired Cognition: A Pilot Study Frontiers in Aging Neuroscience prediabetes mild cognitive impairment hippocampal volume MRI memory test |
| title | One Hour-Post-load Plasma Glucose ≥155 mg/dl in Healthy Glucose Normotolerant Subjects Is Associated With Subcortical Brain MRI Alterations and Impaired Cognition: A Pilot Study |
| title_full | One Hour-Post-load Plasma Glucose ≥155 mg/dl in Healthy Glucose Normotolerant Subjects Is Associated With Subcortical Brain MRI Alterations and Impaired Cognition: A Pilot Study |
| title_fullStr | One Hour-Post-load Plasma Glucose ≥155 mg/dl in Healthy Glucose Normotolerant Subjects Is Associated With Subcortical Brain MRI Alterations and Impaired Cognition: A Pilot Study |
| title_full_unstemmed | One Hour-Post-load Plasma Glucose ≥155 mg/dl in Healthy Glucose Normotolerant Subjects Is Associated With Subcortical Brain MRI Alterations and Impaired Cognition: A Pilot Study |
| title_short | One Hour-Post-load Plasma Glucose ≥155 mg/dl in Healthy Glucose Normotolerant Subjects Is Associated With Subcortical Brain MRI Alterations and Impaired Cognition: A Pilot Study |
| title_sort | one hour post load plasma glucose ≥155 mg dl in healthy glucose normotolerant subjects is associated with subcortical brain mri alterations and impaired cognition a pilot study |
| topic | prediabetes mild cognitive impairment hippocampal volume MRI memory test |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.608736/full |
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