Sacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney disease

Sacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney disease

Abstract Background Tubulointerstitial fibrosis plays an important role in the progression of diabetic kidney disease (DKD). Sacubitril/valsartan (Sac/Val) exerts a robust beneficial effect in DKD. However, the potential functional effect of Sac/Val on tubulointerstitial fibrosis in DKD is still lar...

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Bibliographic Details
Main Authors: Xing-Jian Zhang, Cong-Cong Liu, Zuo-Lin Li, Lin Ding, Yan Zhou, Dong-Jie Zhang, Yao Zhang, Shu-Ting Hou, Rui-Xia Ma
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Diabetic kidney disease
Sacubitril/valsartan
Tubulointerstitial fibrosis
Mitochondria
Sirt1
PGC1α
Online Access:https://doi.org/10.1186/s13098-024-01284-1

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