Killing two birds with one stone: Blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumors
Lactate-based metabolic symbiosis between glycolytic and oxidative cancer cells is known to facilitate tumor growth. We have recently demonstrated that 7ACC2 blocks extracellular lactate uptake via the inhibition of mitochondrial pyruvate carrier. 7ACC2 also prevents compensatory glucose oxidation,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2018.1465016 |
| _version_ | 1797677148532637696 |
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| author | Catherine Vander Linden Cyril Corbet |
| author_facet | Catherine Vander Linden Cyril Corbet |
| author_sort | Catherine Vander Linden |
| collection | DOAJ |
| description | Lactate-based metabolic symbiosis between glycolytic and oxidative cancer cells is known to facilitate tumor growth. We have recently demonstrated that 7ACC2 blocks extracellular lactate uptake via the inhibition of mitochondrial pyruvate carrier. 7ACC2 also prevents compensatory glucose oxidation, induces tumor reoxygenation and potentiates radiotherapy, making it a promising anticancer drug. |
| first_indexed | 2024-03-11T22:40:45Z |
| format | Article |
| id | doaj.art-702ba009108f4711af205d3f59d7c504 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:45Z |
| publishDate | 2018-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-702ba009108f4711af205d3f59d7c5042023-09-22T09:10:59ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-07-015410.1080/23723556.2018.14650161465016Killing two birds with one stone: Blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumorsCatherine Vander Linden0Cyril Corbet1Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de LouvainPole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de LouvainLactate-based metabolic symbiosis between glycolytic and oxidative cancer cells is known to facilitate tumor growth. We have recently demonstrated that 7ACC2 blocks extracellular lactate uptake via the inhibition of mitochondrial pyruvate carrier. 7ACC2 also prevents compensatory glucose oxidation, induces tumor reoxygenation and potentiates radiotherapy, making it a promising anticancer drug.http://dx.doi.org/10.1080/23723556.2018.1465016lactatemitochondrial pyruvate carriermetabolic symbiosismonocarboxylate transportercancerradiation therapy |
| spellingShingle | Catherine Vander Linden Cyril Corbet Killing two birds with one stone: Blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumors Molecular & Cellular Oncology lactate mitochondrial pyruvate carrier metabolic symbiosis monocarboxylate transporter cancer radiation therapy |
| title | Killing two birds with one stone: Blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumors |
| title_full | Killing two birds with one stone: Blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumors |
| title_fullStr | Killing two birds with one stone: Blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumors |
| title_full_unstemmed | Killing two birds with one stone: Blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumors |
| title_short | Killing two birds with one stone: Blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumors |
| title_sort | killing two birds with one stone blocking the mitochondrial pyruvate carrier to inhibit lactate uptake by cancer cells and radiosensitize tumors |
| topic | lactate mitochondrial pyruvate carrier metabolic symbiosis monocarboxylate transporter cancer radiation therapy |
| url | http://dx.doi.org/10.1080/23723556.2018.1465016 |
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