Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling
Plants as sessile organisms can adapt to environmental stress to mitigate its adverse effects. As part of such adaptation they maintain an active memory of heat stress for several days that promotes a more efficient response to recurring stress. We show that this heat stress memory requires the acti...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-09-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/17061 |
| _version_ | 1811180349102751744 |
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| author | Krzysztof Brzezinka Simone Altmann Hjördis Czesnick Philippe Nicolas Michal Gorka Eileen Benke Tina Kabelitz Felix Jähne Alexander Graf Christian Kappel Isabel Bäurle |
| author_facet | Krzysztof Brzezinka Simone Altmann Hjördis Czesnick Philippe Nicolas Michal Gorka Eileen Benke Tina Kabelitz Felix Jähne Alexander Graf Christian Kappel Isabel Bäurle |
| author_sort | Krzysztof Brzezinka |
| collection | DOAJ |
| description | Plants as sessile organisms can adapt to environmental stress to mitigate its adverse effects. As part of such adaptation they maintain an active memory of heat stress for several days that promotes a more efficient response to recurring stress. We show that this heat stress memory requires the activity of the FORGETTER1 (FGT1) locus, with fgt1 mutants displaying reduced maintenance of heat-induced gene expression. FGT1 encodes the Arabidopsis thaliana orthologue of Strawberry notch (Sno), and the protein globally associates with the promoter regions of actively expressed genes in a heat-dependent fashion. FGT1 interacts with chromatin remodelers of the SWI/SNF and ISWI families, which also display reduced heat stress memory. Genomic targets of the BRM remodeler overlap significantly with FGT1 targets. Accordingly, nucleosome dynamics at loci with altered maintenance of heat-induced expression are affected in fgt1. Together, our results suggest that by modulating nucleosome occupancy, FGT1 mediates stress-induced chromatin memory. |
| first_indexed | 2024-04-11T09:01:48Z |
| format | Article |
| id | doaj.art-702eb15c7e6b473faf27c2fcc9daa7a6 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:01:48Z |
| publishDate | 2016-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-702eb15c7e6b473faf27c2fcc9daa7a62022-12-22T04:32:45ZengeLife Sciences Publications LtdeLife2050-084X2016-09-01510.7554/eLife.17061Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodelingKrzysztof Brzezinka0Simone Altmann1Hjördis Czesnick2Philippe Nicolas3Michal Gorka4https://orcid.org/0000-0002-1289-6858Eileen Benke5Tina Kabelitz6Felix Jähne7Alexander Graf8Christian Kappel9https://orcid.org/0000-0002-1450-1864Isabel Bäurle10https://orcid.org/0000-0001-5633-8068Institute for Biochemistry and Biology, University of Potsdam, Potsdam, GermanyInstitute for Biochemistry and Biology, University of Potsdam, Potsdam, GermanyInstitute for Biochemistry and Biology, University of Potsdam, Potsdam, GermanyInstitute for Biochemistry and Biology, University of Potsdam, Potsdam, GermanyMax-Planck-Institute for Molecular Plant Physiology, Potsdam, GermanyInstitute for Biochemistry and Biology, University of Potsdam, Potsdam, GermanyInstitute for Biochemistry and Biology, University of Potsdam, Potsdam, GermanyInstitute for Biochemistry and Biology, University of Potsdam, Potsdam, GermanyMax-Planck-Institute for Molecular Plant Physiology, Potsdam, GermanyInstitute for Biochemistry and Biology, University of Potsdam, Potsdam, GermanyInstitute for Biochemistry and Biology, University of Potsdam, Potsdam, GermanyPlants as sessile organisms can adapt to environmental stress to mitigate its adverse effects. As part of such adaptation they maintain an active memory of heat stress for several days that promotes a more efficient response to recurring stress. We show that this heat stress memory requires the activity of the FORGETTER1 (FGT1) locus, with fgt1 mutants displaying reduced maintenance of heat-induced gene expression. FGT1 encodes the Arabidopsis thaliana orthologue of Strawberry notch (Sno), and the protein globally associates with the promoter regions of actively expressed genes in a heat-dependent fashion. FGT1 interacts with chromatin remodelers of the SWI/SNF and ISWI families, which also display reduced heat stress memory. Genomic targets of the BRM remodeler overlap significantly with FGT1 targets. Accordingly, nucleosome dynamics at loci with altered maintenance of heat-induced expression are affected in fgt1. Together, our results suggest that by modulating nucleosome occupancy, FGT1 mediates stress-induced chromatin memory.https://elifesciences.org/articles/17061primingchromatin memoryDExD/H helicaseheat stressnucleosome remodeling |
| spellingShingle | Krzysztof Brzezinka Simone Altmann Hjördis Czesnick Philippe Nicolas Michal Gorka Eileen Benke Tina Kabelitz Felix Jähne Alexander Graf Christian Kappel Isabel Bäurle Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling eLife priming chromatin memory DExD/H helicase heat stress nucleosome remodeling |
| title | Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling |
| title_full | Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling |
| title_fullStr | Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling |
| title_full_unstemmed | Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling |
| title_short | Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling |
| title_sort | arabidopsis forgetter1 mediates stress induced chromatin memory through nucleosome remodeling |
| topic | priming chromatin memory DExD/H helicase heat stress nucleosome remodeling |
| url | https://elifesciences.org/articles/17061 |
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