Chitosan-based formulation for bone health: A review
Bone health may be impacted by various causes such as dietary deficiencies and metabolic disturbances. The possible use of chitosan (CTS) has also been investigated in improving bone health due to its biodegradability, biocompatibility, and low toxicity. This review aims to study the role of CTS for...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893923000804 |
| _version_ | 1797383660710658048 |
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| author | Aswir Abd Rashed Norazlan Mohmad Misnan Mohd Naeem Mohd Nawi |
| author_facet | Aswir Abd Rashed Norazlan Mohmad Misnan Mohd Naeem Mohd Nawi |
| author_sort | Aswir Abd Rashed |
| collection | DOAJ |
| description | Bone health may be impacted by various causes such as dietary deficiencies and metabolic disturbances. The possible use of chitosan (CTS) has also been investigated in improving bone health due to its biodegradability, biocompatibility, and low toxicity. This review aims to study the role of CTS formulation for maintaining bone health including treating bone-related diseases, particularly osteoporosis. The literature was extracted from three databases (PubMed, Scopus and ScienceDirect) from the year 2011 to 2021 using the Medical subject heading (MeSH) terms “osteoporosis” crossed with the term “chitosan''. Several formulations of CTS have been implemented in helping bone-related diseases such as nanocomposite, hydrogel and scaffolds. A nanocomposite chitosan formulation successfully increased the femur bone's calcification intensity in a study on adult female rats. CTS-based hydrogel has been found to convey mechanical strength similar to the vertebral bone and possess inherent osteoconductive properties. In conclusion, CTS has shown great potential to be used alone or in combination with other materials in treating bone-related diseases. CTS is also extensively investigated for its benefit as a formulation for various applications due to its good biocompatibility and biodegradability. |
| first_indexed | 2024-03-08T21:24:17Z |
| format | Article |
| id | doaj.art-702f35a75bd648cbbf7edf16072225a8 |
| institution | Directory Open Access Journal |
| issn | 2666-8939 |
| language | English |
| last_indexed | 2024-03-08T21:24:17Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj.art-702f35a75bd648cbbf7edf16072225a82023-12-21T07:37:42ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392023-12-016100359Chitosan-based formulation for bone health: A reviewAswir Abd Rashed0Norazlan Mohmad Misnan1Mohd Naeem Mohd Nawi2Nutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Malaysia; Corresponding author.Herbal Medicine Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, MalaysiaNutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, MalaysiaBone health may be impacted by various causes such as dietary deficiencies and metabolic disturbances. The possible use of chitosan (CTS) has also been investigated in improving bone health due to its biodegradability, biocompatibility, and low toxicity. This review aims to study the role of CTS formulation for maintaining bone health including treating bone-related diseases, particularly osteoporosis. The literature was extracted from three databases (PubMed, Scopus and ScienceDirect) from the year 2011 to 2021 using the Medical subject heading (MeSH) terms “osteoporosis” crossed with the term “chitosan''. Several formulations of CTS have been implemented in helping bone-related diseases such as nanocomposite, hydrogel and scaffolds. A nanocomposite chitosan formulation successfully increased the femur bone's calcification intensity in a study on adult female rats. CTS-based hydrogel has been found to convey mechanical strength similar to the vertebral bone and possess inherent osteoconductive properties. In conclusion, CTS has shown great potential to be used alone or in combination with other materials in treating bone-related diseases. CTS is also extensively investigated for its benefit as a formulation for various applications due to its good biocompatibility and biodegradability.http://www.sciencedirect.com/science/article/pii/S2666893923000804ChitosanBone healthIn vitroIn vivoFormulation |
| spellingShingle | Aswir Abd Rashed Norazlan Mohmad Misnan Mohd Naeem Mohd Nawi Chitosan-based formulation for bone health: A review Carbohydrate Polymer Technologies and Applications Chitosan Bone health In vitro In vivo Formulation |
| title | Chitosan-based formulation for bone health: A review |
| title_full | Chitosan-based formulation for bone health: A review |
| title_fullStr | Chitosan-based formulation for bone health: A review |
| title_full_unstemmed | Chitosan-based formulation for bone health: A review |
| title_short | Chitosan-based formulation for bone health: A review |
| title_sort | chitosan based formulation for bone health a review |
| topic | Chitosan Bone health In vitro In vivo Formulation |
| url | http://www.sciencedirect.com/science/article/pii/S2666893923000804 |
| work_keys_str_mv | AT aswirabdrashed chitosanbasedformulationforbonehealthareview AT norazlanmohmadmisnan chitosanbasedformulationforbonehealthareview AT mohdnaeemmohdnawi chitosanbasedformulationforbonehealthareview |