Conformational diversity and protein–protein interfaces in drug repurposing in Ras signaling pathway

Conformational diversity and protein–protein interfaces in drug repurposing in Ras signaling pathway

Abstract We focus on drug repurposing in the Ras signaling pathway, considering structural similarities of protein–protein interfaces. The interfaces formed by physically interacting proteins are found from PDB if available and via PRISM (PRotein Interaction by Structural Matching) otherwise. The st...

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Bibliographic Details
Main Authors: Ahenk Zeynep Sayin, Zeynep Abali, Simge Senyuz, Fatma Cankara, Attila Gursoy, Ozlem Keskin
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-50913-8

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