Mitochondrial Permeability Transition Causes Mitochondrial Reactive Oxygen Species- and Caspase 3-Dependent Atrophy of Single Adult Mouse Skeletal Muscle Fibers

Mitochondrial Permeability Transition Causes Mitochondrial Reactive Oxygen Species- and Caspase 3-Dependent Atrophy of Single Adult Mouse Skeletal Muscle Fibers

Elevated mitochondrial reactive oxygen species (mROS) and an increase in caspase-3 activity are established mechanisms that lead to skeletal muscle atrophy via the upregulation of protein degradation pathways. However, the mechanisms upstream of an increase in mROS and caspase-3 activity in conditio...

Full description

Bibliographic Details
Main Authors: Sarah K. Skinner, Angelo Solania, Dennis W. Wolan, Michael S. Cohen, Terence E. Ryan, Russell T. Hepple
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
mitochondrial permeability transition pore
ROS
caspase-3
skeletal muscle atrophy
Online Access:https://www.mdpi.com/2073-4409/10/10/2586

Similar Items

Similar Items