Institute for clinical and economic review (ICER) psoriasis update 2018: what it means for dermatologists treating moderate-to-severe plaque psoriasis
Objective: This paper aims to summarize the key findings of the updated report issued in August 2018 by the Institute of Clinical and Economic Review (ICER) regarding the clinical efficacy and budget impact of various immunomodulators. Methods: This paper specifically focuses on the inclusion of two...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-11-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2019.1573307 |
| _version_ | 1797683693590937600 |
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| author | Erica B. Lee Deeti J. Pithadia Kelly A. Reynolds Jashin J. Wu |
| author_facet | Erica B. Lee Deeti J. Pithadia Kelly A. Reynolds Jashin J. Wu |
| author_sort | Erica B. Lee |
| collection | DOAJ |
| description | Objective: This paper aims to summarize the key findings of the updated report issued in August 2018 by the Institute of Clinical and Economic Review (ICER) regarding the clinical efficacy and budget impact of various immunomodulators. Methods: This paper specifically focuses on the inclusion of two new biologics, guselkumab and certolizumab in the context of their relative cost-effectiveness using analyses on sequential implementation of specific first- and second-line therapies. Results: The ICER found that initiating biologic therapy with an IL-17 inhibitor or guselkumab results in the most clinical improvement, but is also associated with higher costs. The ICER also found that guselkumab and certolizumab would need to be discounted significantly in order to achieve cost-effectiveness by standard metrics of $50,000-$150,000 per QALY. Conclusion: The ICER report demonstrates a need for more consensus guidelines in the use of biologics in the treatment of psoriasis, and perhaps consideration of costs within these guidelines. |
| first_indexed | 2024-03-12T00:18:09Z |
| format | Article |
| id | doaj.art-7032bd3c59a041c98b87468847ddead1 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:18:09Z |
| publishDate | 2019-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-7032bd3c59a041c98b87468847ddead12023-09-15T14:08:34ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532019-11-0130877277410.1080/09546634.2019.15733071573307Institute for clinical and economic review (ICER) psoriasis update 2018: what it means for dermatologists treating moderate-to-severe plaque psoriasisErica B. Lee0Deeti J. Pithadia1Kelly A. Reynolds2Jashin J. Wu3University of HawaiiAugusta UniversityCollege of Medicine, University of CinicinnatiDermatology Research and Education FoundationObjective: This paper aims to summarize the key findings of the updated report issued in August 2018 by the Institute of Clinical and Economic Review (ICER) regarding the clinical efficacy and budget impact of various immunomodulators. Methods: This paper specifically focuses on the inclusion of two new biologics, guselkumab and certolizumab in the context of their relative cost-effectiveness using analyses on sequential implementation of specific first- and second-line therapies. Results: The ICER found that initiating biologic therapy with an IL-17 inhibitor or guselkumab results in the most clinical improvement, but is also associated with higher costs. The ICER also found that guselkumab and certolizumab would need to be discounted significantly in order to achieve cost-effectiveness by standard metrics of $50,000-$150,000 per QALY. Conclusion: The ICER report demonstrates a need for more consensus guidelines in the use of biologics in the treatment of psoriasis, and perhaps consideration of costs within these guidelines.http://dx.doi.org/10.1080/09546634.2019.1573307psoriasisicercost-effectiveness |
| spellingShingle | Erica B. Lee Deeti J. Pithadia Kelly A. Reynolds Jashin J. Wu Institute for clinical and economic review (ICER) psoriasis update 2018: what it means for dermatologists treating moderate-to-severe plaque psoriasis Journal of Dermatological Treatment psoriasis icer cost-effectiveness |
| title | Institute for clinical and economic review (ICER) psoriasis update 2018: what it means for dermatologists treating moderate-to-severe plaque psoriasis |
| title_full | Institute for clinical and economic review (ICER) psoriasis update 2018: what it means for dermatologists treating moderate-to-severe plaque psoriasis |
| title_fullStr | Institute for clinical and economic review (ICER) psoriasis update 2018: what it means for dermatologists treating moderate-to-severe plaque psoriasis |
| title_full_unstemmed | Institute for clinical and economic review (ICER) psoriasis update 2018: what it means for dermatologists treating moderate-to-severe plaque psoriasis |
| title_short | Institute for clinical and economic review (ICER) psoriasis update 2018: what it means for dermatologists treating moderate-to-severe plaque psoriasis |
| title_sort | institute for clinical and economic review icer psoriasis update 2018 what it means for dermatologists treating moderate to severe plaque psoriasis |
| topic | psoriasis icer cost-effectiveness |
| url | http://dx.doi.org/10.1080/09546634.2019.1573307 |
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