Luseogliflozin inhibits high glucose-induced TGF-2 expression in mouse cardiomyocytes by suppressing NHE-1 activity

Luseogliflozin inhibits high glucose-induced TGF-2 expression in mouse cardiomyocytes by suppressing NHE-1 activity

Objective Sodium-glucose cotransporter-2 (SGLT2) inhibitors exhibit cardioprotective properties in patients with diabetes. However, SGLT2 is not expressed in the heart, and the underlying molecular mechanisms are not fully understood. We investigated whether the SGLT2 inhibitor luseogliflozin exerts...

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Bibliographic Details
Main Authors:	Naoya Osaka, Yusaku Mori, Michishige Terasaki, Munenori Hiromura, Tomomi Saito, Hironori Yashima, Yoshie Shiraga, Raichi Kawakami, Makoto Ohara, Tomoyasu Fukui, Sho-ichi Yamagishi
Format:	Article
Language:	English
Published:	SAGE Publishing 2022-05-01
Series:	Journal of International Medical Research
Online Access:	https://doi.org/10.1177/03000605221097490

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