Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2
Summary: The hippocampus is critical for the formation of episodic memory. It is, therefore, important to understand intra-hippocampal circuitry, especially in the often overlooked area CA2. Using specific transgenic mouse lines combined with opto- and chemogenetics, we show that local plasticity of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-04-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719303213 |
| _version_ | 1818700231369293824 |
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| author | Kaoutsar Nasrallah Ludivine Therreau Vincent Robert Arthur J.Y. Huang Thomas J. McHugh Rebecca A. Piskorowski Vivien Chevaleyre |
| author_facet | Kaoutsar Nasrallah Ludivine Therreau Vincent Robert Arthur J.Y. Huang Thomas J. McHugh Rebecca A. Piskorowski Vivien Chevaleyre |
| author_sort | Kaoutsar Nasrallah |
| collection | DOAJ |
| description | Summary: The hippocampus is critical for the formation of episodic memory. It is, therefore, important to understand intra-hippocampal circuitry, especially in the often overlooked area CA2. Using specific transgenic mouse lines combined with opto- and chemogenetics, we show that local plasticity of parvalbumin-expressing interneurons in area CA2 allows CA3 input to recruit CA2 pyramidal neurons (PNs), thereby increasing the excitatory drive between CA3 and CA1. CA2 PNs provide both stronger excitation and larger feed-forward inhibition onto deep, compared with superficial, CA1 PNs. This feed-forward inhibition, largely mediated by parvalbumin-expressing interneurons, normalizes the excitatory drive onto deep and superficial CA1 PNs. Finally, we identify a target of CA2 in area CA1, i.e., CA1 PNs, whose soma are located in stratum radiatum. These data provide insight into local hippocampal circuitry and reveal how localized plasticity can potentially control information flow in the larger hippocampal network. : Nasrallah et al. show how recruitment of CA2 pyramidal neurons can considerably influence CA1 output when these cells are recruited by CA3. Parvalbumin-expressing interneurons have a critical role in regulating CA2 output and normalize the excitatory drive from CA2 to CA1. In addition, CA2 strongly excites radiatum giant cells. Keywords: hippocampus, area CA2, parvalbumin-interneuron, long-term depression, disinhibition, area CA1, radiatum giant cells, delta opioid receptors |
| first_indexed | 2024-12-17T15:01:39Z |
| format | Article |
| id | doaj.art-703a2f4d4ece41b0bf0763857e39d5f0 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-17T15:01:39Z |
| publishDate | 2019-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-703a2f4d4ece41b0bf0763857e39d5f02022-12-21T21:43:54ZengElsevierCell Reports2211-12472019-04-012718698.e3Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2Kaoutsar Nasrallah0Ludivine Therreau1Vincent Robert2Arthur J.Y. Huang3Thomas J. McHugh4Rebecca A. Piskorowski5Vivien Chevaleyre6Team Synaptic Plasticity and Neural Networks, INSERM UMR-S1266 Institute of Psychiatry and Neuroscience of Paris, Université Paris Descartes, 102-108 Rue de la Santé, 75014 Paris, FranceTeam Synaptic Plasticity and Neural Networks, INSERM UMR-S1266 Institute of Psychiatry and Neuroscience of Paris, Université Paris Descartes, 102-108 Rue de la Santé, 75014 Paris, FranceTeam Synaptic Plasticity and Neural Networks, INSERM UMR-S1266 Institute of Psychiatry and Neuroscience of Paris, Université Paris Descartes, 102-108 Rue de la Santé, 75014 Paris, FranceLaboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, 2-1 Hirosawa, Wakoshi, Saitama 351-0198, JapanLaboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, 2-1 Hirosawa, Wakoshi, Saitama 351-0198, JapanTeam Synaptic Plasticity and Neural Networks, INSERM UMR-S1266 Institute of Psychiatry and Neuroscience of Paris, Université Paris Descartes, 102-108 Rue de la Santé, 75014 Paris, France; Corresponding authorTeam Synaptic Plasticity and Neural Networks, INSERM UMR-S1266 Institute of Psychiatry and Neuroscience of Paris, Université Paris Descartes, 102-108 Rue de la Santé, 75014 Paris, France; Corresponding authorSummary: The hippocampus is critical for the formation of episodic memory. It is, therefore, important to understand intra-hippocampal circuitry, especially in the often overlooked area CA2. Using specific transgenic mouse lines combined with opto- and chemogenetics, we show that local plasticity of parvalbumin-expressing interneurons in area CA2 allows CA3 input to recruit CA2 pyramidal neurons (PNs), thereby increasing the excitatory drive between CA3 and CA1. CA2 PNs provide both stronger excitation and larger feed-forward inhibition onto deep, compared with superficial, CA1 PNs. This feed-forward inhibition, largely mediated by parvalbumin-expressing interneurons, normalizes the excitatory drive onto deep and superficial CA1 PNs. Finally, we identify a target of CA2 in area CA1, i.e., CA1 PNs, whose soma are located in stratum radiatum. These data provide insight into local hippocampal circuitry and reveal how localized plasticity can potentially control information flow in the larger hippocampal network. : Nasrallah et al. show how recruitment of CA2 pyramidal neurons can considerably influence CA1 output when these cells are recruited by CA3. Parvalbumin-expressing interneurons have a critical role in regulating CA2 output and normalize the excitatory drive from CA2 to CA1. In addition, CA2 strongly excites radiatum giant cells. Keywords: hippocampus, area CA2, parvalbumin-interneuron, long-term depression, disinhibition, area CA1, radiatum giant cells, delta opioid receptorshttp://www.sciencedirect.com/science/article/pii/S2211124719303213 |
| spellingShingle | Kaoutsar Nasrallah Ludivine Therreau Vincent Robert Arthur J.Y. Huang Thomas J. McHugh Rebecca A. Piskorowski Vivien Chevaleyre Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2 Cell Reports |
| title | Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2 |
| title_full | Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2 |
| title_fullStr | Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2 |
| title_full_unstemmed | Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2 |
| title_short | Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2 |
| title_sort | routing hippocampal information flow through parvalbumin interneuron plasticity in area ca2 |
| url | http://www.sciencedirect.com/science/article/pii/S2211124719303213 |
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