Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies
Worldwide urbanization and subsequent migration have accelerated the emergence and spread of diverse novel human diseases. Among them, diseases caused by viruses could result in epidemics, typified by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which hit the globe towards the en...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-03-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/17/3/328 |
| _version_ | 1797239725906460672 |
|---|---|
| author | Queency N. Okechukwu Feyisayo O. Adepoju Osman N. Kanwugu Parise Adadi Ángel Serrano-Aroca Vladimir N. Uversky Charles Odilichukwu R. Okpala |
| author_facet | Queency N. Okechukwu Feyisayo O. Adepoju Osman N. Kanwugu Parise Adadi Ángel Serrano-Aroca Vladimir N. Uversky Charles Odilichukwu R. Okpala |
| author_sort | Queency N. Okechukwu |
| collection | DOAJ |
| description | Worldwide urbanization and subsequent migration have accelerated the emergence and spread of diverse novel human diseases. Among them, diseases caused by viruses could result in epidemics, typified by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which hit the globe towards the end of December 2019. The global battle against SARS-CoV-2 has reignited interest in finding alternative treatments for viral infections. The marine world offers a large repository of diverse and unique bioactive compounds. Over the years, many antiviral compounds from marine organisms have been isolated and tested in vitro and in vivo. However, given the increasing need for alternative treatment, in silico analysis appears to provide a time- and cost-effective approach to identifying the potential antiviral compounds from the vast pool of natural metabolites isolated from marine organisms. In this perspective review, we discuss marine-derived bioactive metabolites as potential therapeutics for all known disease-causing viruses including the SARS-CoV-2. We demonstrate the efficacy of marine-derived bioactive metabolites in the context of various antiviral activities and their in silico, in vitro, and in vivo capacities. |
| first_indexed | 2024-04-24T17:56:07Z |
| format | Article |
| id | doaj.art-703a73d5d41742bc8618c9d6f5ecd1fc |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-04-24T17:56:07Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-703a73d5d41742bc8618c9d6f5ecd1fc2024-03-27T13:59:18ZengMDPI AGPharmaceuticals1424-82472024-03-0117332810.3390/ph17030328Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical StudiesQueency N. Okechukwu0Feyisayo O. Adepoju1Osman N. Kanwugu2Parise Adadi3Ángel Serrano-Aroca4Vladimir N. Uversky5Charles Odilichukwu R. Okpala6Institute of Chemical Technology, Ural Federal University Named after the First President of Russia B. N. Yeltsin, Mira Street 28, Yekaterinburg 620002, RussiaInstitute of Chemical Technology, Ural Federal University Named after the First President of Russia B. N. Yeltsin, Mira Street 28, Yekaterinburg 620002, RussiaARC Centre of Excellence in Synthetic Biology, School of Natural Sciences, Macquarie University, Sydney, NSW 2109, AustraliaDepartment of Food Science, University of Otago, Dunedin 9054, New ZealandBiomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, SpainDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USAUGA Cooperative Extension, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA 30602, USAWorldwide urbanization and subsequent migration have accelerated the emergence and spread of diverse novel human diseases. Among them, diseases caused by viruses could result in epidemics, typified by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which hit the globe towards the end of December 2019. The global battle against SARS-CoV-2 has reignited interest in finding alternative treatments for viral infections. The marine world offers a large repository of diverse and unique bioactive compounds. Over the years, many antiviral compounds from marine organisms have been isolated and tested in vitro and in vivo. However, given the increasing need for alternative treatment, in silico analysis appears to provide a time- and cost-effective approach to identifying the potential antiviral compounds from the vast pool of natural metabolites isolated from marine organisms. In this perspective review, we discuss marine-derived bioactive metabolites as potential therapeutics for all known disease-causing viruses including the SARS-CoV-2. We demonstrate the efficacy of marine-derived bioactive metabolites in the context of various antiviral activities and their in silico, in vitro, and in vivo capacities.https://www.mdpi.com/1424-8247/17/3/328SARS-CoV-2therapeuticspandemicmarine metabolitesmarine organismsviruses |
| spellingShingle | Queency N. Okechukwu Feyisayo O. Adepoju Osman N. Kanwugu Parise Adadi Ángel Serrano-Aroca Vladimir N. Uversky Charles Odilichukwu R. Okpala Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies Pharmaceuticals SARS-CoV-2 therapeutics pandemic marine metabolites marine organisms viruses |
| title | Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies |
| title_full | Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies |
| title_fullStr | Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies |
| title_full_unstemmed | Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies |
| title_short | Marine-Derived Bioactive Metabolites as a Potential Therapeutic Intervention in Managing Viral Diseases: Insights from the SARS-CoV-2 In Silico and Pre-Clinical Studies |
| title_sort | marine derived bioactive metabolites as a potential therapeutic intervention in managing viral diseases insights from the sars cov 2 in silico and pre clinical studies |
| topic | SARS-CoV-2 therapeutics pandemic marine metabolites marine organisms viruses |
| url | https://www.mdpi.com/1424-8247/17/3/328 |
| work_keys_str_mv | AT queencynokechukwu marinederivedbioactivemetabolitesasapotentialtherapeuticinterventioninmanagingviraldiseasesinsightsfromthesarscov2insilicoandpreclinicalstudies AT feyisayooadepoju marinederivedbioactivemetabolitesasapotentialtherapeuticinterventioninmanagingviraldiseasesinsightsfromthesarscov2insilicoandpreclinicalstudies AT osmannkanwugu marinederivedbioactivemetabolitesasapotentialtherapeuticinterventioninmanagingviraldiseasesinsightsfromthesarscov2insilicoandpreclinicalstudies AT pariseadadi marinederivedbioactivemetabolitesasapotentialtherapeuticinterventioninmanagingviraldiseasesinsightsfromthesarscov2insilicoandpreclinicalstudies AT angelserranoaroca marinederivedbioactivemetabolitesasapotentialtherapeuticinterventioninmanagingviraldiseasesinsightsfromthesarscov2insilicoandpreclinicalstudies AT vladimirnuversky marinederivedbioactivemetabolitesasapotentialtherapeuticinterventioninmanagingviraldiseasesinsightsfromthesarscov2insilicoandpreclinicalstudies AT charlesodilichukwurokpala marinederivedbioactivemetabolitesasapotentialtherapeuticinterventioninmanagingviraldiseasesinsightsfromthesarscov2insilicoandpreclinicalstudies |