Effects of sub-chronic CRH administration into the hypothalamic paraventricular and central amygdala nuclei in male rats with a focus on food intake biomarkers
Abstract CRH neurons are found in the paraventricular nucleus(PVN) and central amygdala(CeA) nuclei. This study investigated the effects of sub-chronic CRH administration into the PVN and CeA nuclei on food intake biomarkers in rats divided into five groups: control, two shams, and two CRH-PVN and C...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2023-12-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652023000700806&lng=en&tlng=en |
| _version_ | 1797394277854085120 |
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| author | ATEFEH RAYATPOUR MARYAM RADAHMADI MINA S. IZADI MAEDEH GHASEMI |
| author_facet | ATEFEH RAYATPOUR MARYAM RADAHMADI MINA S. IZADI MAEDEH GHASEMI |
| author_sort | ATEFEH RAYATPOUR |
| collection | DOAJ |
| description | Abstract CRH neurons are found in the paraventricular nucleus(PVN) and central amygdala(CeA) nuclei. This study investigated the effects of sub-chronic CRH administration into the PVN and CeA nuclei on food intake biomarkers in rats divided into five groups: control, two shams, and two CRH-PVN and CRH-CeA groups(receiving CRH in nuclei for seven days). The CRH-PVN group had significantly higher cumulative food intake and food intake trends than the CRH-CeA group. The CRH-CeA and CRH-PVN groups exhibited significant increases in food intake during hours 1 and 2, respectively. Moreover, to be time-dependent, food intake is modulated by different brain nuclei. The CRH signaling pathway appeared to be activated later in the PVN than CeA. Both groups exhibited significantly higher leptin levels, the CRH-PVN group exhibited higher ghrelin levels and lower glucose levels. Repetitive administration of CRH into the PVN and CeA significantly reduced body weight differences. CRH administration into the PVN affected both leptin and ghrelin levels, but ghrelin had a greater impact on glucose variations and cumulative food intake than leptin. Finally, CRH administration into the PVN and CeA likely activated the HPA axis, and the CeA had a greater impact on the stress circuit than on food intake behavior. |
| first_indexed | 2024-03-09T00:16:10Z |
| format | Article |
| id | doaj.art-703e40f94f804be596809ad7438fdcc4 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-03-09T00:16:10Z |
| publishDate | 2023-12-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-703e40f94f804be596809ad7438fdcc42023-12-12T07:52:01ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902023-12-0195410.1590/0001-3765202320200221Effects of sub-chronic CRH administration into the hypothalamic paraventricular and central amygdala nuclei in male rats with a focus on food intake biomarkersATEFEH RAYATPOURhttps://orcid.org/0000-0002-8608-4529MARYAM RADAHMADIhttps://orcid.org/0000-0002-1383-9572MINA S. IZADIhttps://orcid.org/0000-0001-8368-9672MAEDEH GHASEMIhttps://orcid.org/0000-0002-5414-9594Abstract CRH neurons are found in the paraventricular nucleus(PVN) and central amygdala(CeA) nuclei. This study investigated the effects of sub-chronic CRH administration into the PVN and CeA nuclei on food intake biomarkers in rats divided into five groups: control, two shams, and two CRH-PVN and CRH-CeA groups(receiving CRH in nuclei for seven days). The CRH-PVN group had significantly higher cumulative food intake and food intake trends than the CRH-CeA group. The CRH-CeA and CRH-PVN groups exhibited significant increases in food intake during hours 1 and 2, respectively. Moreover, to be time-dependent, food intake is modulated by different brain nuclei. The CRH signaling pathway appeared to be activated later in the PVN than CeA. Both groups exhibited significantly higher leptin levels, the CRH-PVN group exhibited higher ghrelin levels and lower glucose levels. Repetitive administration of CRH into the PVN and CeA significantly reduced body weight differences. CRH administration into the PVN affected both leptin and ghrelin levels, but ghrelin had a greater impact on glucose variations and cumulative food intake than leptin. Finally, CRH administration into the PVN and CeA likely activated the HPA axis, and the CeA had a greater impact on the stress circuit than on food intake behavior.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652023000700806&lng=en&tlng=enCentral amygdalaCorticotropin-releasing hormoneFood intakeGhrelinLeptinParaventricular nucleus |
| spellingShingle | ATEFEH RAYATPOUR MARYAM RADAHMADI MINA S. IZADI MAEDEH GHASEMI Effects of sub-chronic CRH administration into the hypothalamic paraventricular and central amygdala nuclei in male rats with a focus on food intake biomarkers Anais da Academia Brasileira de Ciências Central amygdala Corticotropin-releasing hormone Food intake Ghrelin Leptin Paraventricular nucleus |
| title | Effects of sub-chronic CRH administration into the hypothalamic paraventricular and central amygdala nuclei in male rats with a focus on food intake biomarkers |
| title_full | Effects of sub-chronic CRH administration into the hypothalamic paraventricular and central amygdala nuclei in male rats with a focus on food intake biomarkers |
| title_fullStr | Effects of sub-chronic CRH administration into the hypothalamic paraventricular and central amygdala nuclei in male rats with a focus on food intake biomarkers |
| title_full_unstemmed | Effects of sub-chronic CRH administration into the hypothalamic paraventricular and central amygdala nuclei in male rats with a focus on food intake biomarkers |
| title_short | Effects of sub-chronic CRH administration into the hypothalamic paraventricular and central amygdala nuclei in male rats with a focus on food intake biomarkers |
| title_sort | effects of sub chronic crh administration into the hypothalamic paraventricular and central amygdala nuclei in male rats with a focus on food intake biomarkers |
| topic | Central amygdala Corticotropin-releasing hormone Food intake Ghrelin Leptin Paraventricular nucleus |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652023000700806&lng=en&tlng=en |
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