Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease

Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease

Selective neuronal loss is a hallmark of neurodegenerative diseases, including Huntington’s disease (HD). Although mutant huntingtin, the protein responsible for Huntington’s disease, is expressed ubiquitously, a subpopulation of neurons in the striatum is the first to succumb. In this review, we ex...

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Bibliographic Details
Main Authors: Julia eMargulis, Steven eFinkbeiner
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Autophagy
Striatum
proteostasis
Proteasome
Huntington’s disease
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00218/full

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