The therapeutic effects of magnesium in insulin secretion and insulin resistance
Insulin resistance (IR) is a chronic pathological condition that is related to reduce the rates of glucose uptake, especially in the liver, muscle, and adipose tissue as target tissues. Metabolic syndrome and type 2 diabetes mellitus can occur following progression of the disease. The majority of pr...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Advanced Biomedical Research |
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| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2022;volume=11;issue=1;spage=54;epage=54;aulast=Hosseini |
| _version_ | 1818473938297028608 |
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| author | Azadehalsadat Hosseini Dastgerdi Mahtab Ghanbari Rad Nepton Soltani |
| author_facet | Azadehalsadat Hosseini Dastgerdi Mahtab Ghanbari Rad Nepton Soltani |
| author_sort | Azadehalsadat Hosseini Dastgerdi |
| collection | DOAJ |
| description | Insulin resistance (IR) is a chronic pathological condition that is related to reduce the rates of glucose uptake, especially in the liver, muscle, and adipose tissue as target tissues. Metabolic syndrome and type 2 diabetes mellitus can occur following progression of the disease. The majority of prior research has applied that some cations such as magnesium (Mg2+) have important physiological role in insulin metabolism. Mg2+ is the fourth most abundant mineral in the human body that gets involved as a cofactor of various enzymes in several metabolic events, such as carbohydrate oxidation, and it has a fundamental role in glucose transporting mechanism of the cell membrane. This cation has numerous duties in the human body such as regulation of insulin secretion in pancreatic beta-cells and phosphorylation of the insulin receptors in target cells and also gets involved in other downstream signal kinases as intracellular cation. On this basis, intracellular Mg2+ balancing is vital for adequate carbohydrate metabolism. This paper summarizes the present knowledge about the therapeutic effects of Mg2+ in reducing IR in liver, muscle, and pancreases with different mechanisms. For this, the search was performed in Google Scholar, PubMed, Scopus, and Web of Science by insulin resistance, skeletal muscle, liver, pancreases, magnesium, Mg2+, and inflammation keywords. |
| first_indexed | 2024-04-14T04:29:32Z |
| format | Article |
| id | doaj.art-703f8fb721c3447cb5d83dfca1005486 |
| institution | Directory Open Access Journal |
| issn | 2277-9175 |
| language | English |
| last_indexed | 2024-04-14T04:29:32Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-703f8fb721c3447cb5d83dfca10054862022-12-22T02:12:07ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752022-01-01111545410.4103/abr.abr_366_21The therapeutic effects of magnesium in insulin secretion and insulin resistanceAzadehalsadat Hosseini DastgerdiMahtab Ghanbari RadNepton SoltaniInsulin resistance (IR) is a chronic pathological condition that is related to reduce the rates of glucose uptake, especially in the liver, muscle, and adipose tissue as target tissues. Metabolic syndrome and type 2 diabetes mellitus can occur following progression of the disease. The majority of prior research has applied that some cations such as magnesium (Mg2+) have important physiological role in insulin metabolism. Mg2+ is the fourth most abundant mineral in the human body that gets involved as a cofactor of various enzymes in several metabolic events, such as carbohydrate oxidation, and it has a fundamental role in glucose transporting mechanism of the cell membrane. This cation has numerous duties in the human body such as regulation of insulin secretion in pancreatic beta-cells and phosphorylation of the insulin receptors in target cells and also gets involved in other downstream signal kinases as intracellular cation. On this basis, intracellular Mg2+ balancing is vital for adequate carbohydrate metabolism. This paper summarizes the present knowledge about the therapeutic effects of Mg2+ in reducing IR in liver, muscle, and pancreases with different mechanisms. For this, the search was performed in Google Scholar, PubMed, Scopus, and Web of Science by insulin resistance, skeletal muscle, liver, pancreases, magnesium, Mg2+, and inflammation keywords.http://www.advbiores.net/article.asp?issn=2277-9175;year=2022;volume=11;issue=1;spage=54;epage=54;aulast=Hosseinidiabetesglucoseinsulin resistancemagnesium |
| spellingShingle | Azadehalsadat Hosseini Dastgerdi Mahtab Ghanbari Rad Nepton Soltani The therapeutic effects of magnesium in insulin secretion and insulin resistance Advanced Biomedical Research diabetes glucose insulin resistance magnesium |
| title | The therapeutic effects of magnesium in insulin secretion and insulin resistance |
| title_full | The therapeutic effects of magnesium in insulin secretion and insulin resistance |
| title_fullStr | The therapeutic effects of magnesium in insulin secretion and insulin resistance |
| title_full_unstemmed | The therapeutic effects of magnesium in insulin secretion and insulin resistance |
| title_short | The therapeutic effects of magnesium in insulin secretion and insulin resistance |
| title_sort | therapeutic effects of magnesium in insulin secretion and insulin resistance |
| topic | diabetes glucose insulin resistance magnesium |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2022;volume=11;issue=1;spage=54;epage=54;aulast=Hosseini |
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