A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption
Liver disease: Beneficial bacteria divert dietary fats Intestinal bacteria that consume common fatty acids could help protect their hosts against non-alcoholic fatty liver disease (NAFLD). The accumulation of lipids over the course of NAFLD can produce serious inflammation and ultimately lead to liv...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-08-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-019-0293-4 |
| Summary: | Liver disease: Beneficial bacteria divert dietary fats Intestinal bacteria that consume common fatty acids could help protect their hosts against non-alcoholic fatty liver disease (NAFLD). The accumulation of lipids over the course of NAFLD can produce serious inflammation and ultimately lead to liver failure. The gut microbiome plays a prominent role in metabolic health and South Korean researchers led by Hui-Young Lee of Gachon University, Incheon, and Jae-Hak Park of Seoul National University, Seoul, have identified a bacterial species that could help prevent NAFLD. They found that Lactobacillus rhamnosus GG can absorb oleic acid, a fatty acid commonly found in the human diet. Transplantation of these bacteria into high-fat diet-fed mice resulted in weight loss and reduced fat accumulation in the liver. These findings providing a new mechanistic insight into the impact of certain probiotic species on NAFLD. |
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| ISSN: | 1226-3613 2092-6413 |