A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption
Liver disease: Beneficial bacteria divert dietary fats Intestinal bacteria that consume common fatty acids could help protect their hosts against non-alcoholic fatty liver disease (NAFLD). The accumulation of lipids over the course of NAFLD can produce serious inflammation and ultimately lead to liv...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-08-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-019-0293-4 |
| _version_ | 1818620547372679168 |
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| author | Hye Rim Jang Hyun-Jun Park Dongwon Kang Hayung Chung Myung Hee Nam Yeonhee Lee Jae-Hak Park Hui-Young Lee |
| author_facet | Hye Rim Jang Hyun-Jun Park Dongwon Kang Hayung Chung Myung Hee Nam Yeonhee Lee Jae-Hak Park Hui-Young Lee |
| author_sort | Hye Rim Jang |
| collection | DOAJ |
| description | Liver disease: Beneficial bacteria divert dietary fats Intestinal bacteria that consume common fatty acids could help protect their hosts against non-alcoholic fatty liver disease (NAFLD). The accumulation of lipids over the course of NAFLD can produce serious inflammation and ultimately lead to liver failure. The gut microbiome plays a prominent role in metabolic health and South Korean researchers led by Hui-Young Lee of Gachon University, Incheon, and Jae-Hak Park of Seoul National University, Seoul, have identified a bacterial species that could help prevent NAFLD. They found that Lactobacillus rhamnosus GG can absorb oleic acid, a fatty acid commonly found in the human diet. Transplantation of these bacteria into high-fat diet-fed mice resulted in weight loss and reduced fat accumulation in the liver. These findings providing a new mechanistic insight into the impact of certain probiotic species on NAFLD. |
| first_indexed | 2024-12-16T17:55:07Z |
| format | Article |
| id | doaj.art-7041ca35c6604dd59f86b8d004e9082f |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-16T17:55:07Z |
| publishDate | 2019-08-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-7041ca35c6604dd59f86b8d004e9082f2022-12-21T22:22:11ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132019-08-0151811410.1038/s12276-019-0293-4A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorptionHye Rim Jang0Hyun-Jun Park1Dongwon Kang2Hayung Chung3Myung Hee Nam4Yeonhee Lee5Jae-Hak Park6Hui-Young Lee7Laboratory of Mitochondrial and Metabolic Diseases, Department of Health Sciences and Technology, GAIHST, Gachon UniversityLaboratory of Mitochondrial and Metabolic Diseases, Department of Health Sciences and Technology, GAIHST, Gachon UniversityLaboratory of Mitochondrial and Metabolic Diseases, Department of Health Sciences and Technology, GAIHST, Gachon UniversitySeoul Center, Korea Basic Science InstituteSeoul Center, Korea Basic Science InstituteCulture Collection of Antimicrobial Resistant Microbes, Department of Horticulture, Biotechnology and Landscape Architecture, Seoul Women’s UniversityKorea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon UniversityLaboratory of Mitochondrial and Metabolic Diseases, Department of Health Sciences and Technology, GAIHST, Gachon UniversityLiver disease: Beneficial bacteria divert dietary fats Intestinal bacteria that consume common fatty acids could help protect their hosts against non-alcoholic fatty liver disease (NAFLD). The accumulation of lipids over the course of NAFLD can produce serious inflammation and ultimately lead to liver failure. The gut microbiome plays a prominent role in metabolic health and South Korean researchers led by Hui-Young Lee of Gachon University, Incheon, and Jae-Hak Park of Seoul National University, Seoul, have identified a bacterial species that could help prevent NAFLD. They found that Lactobacillus rhamnosus GG can absorb oleic acid, a fatty acid commonly found in the human diet. Transplantation of these bacteria into high-fat diet-fed mice resulted in weight loss and reduced fat accumulation in the liver. These findings providing a new mechanistic insight into the impact of certain probiotic species on NAFLD.https://doi.org/10.1038/s12276-019-0293-4 |
| spellingShingle | Hye Rim Jang Hyun-Jun Park Dongwon Kang Hayung Chung Myung Hee Nam Yeonhee Lee Jae-Hak Park Hui-Young Lee A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption Experimental and Molecular Medicine |
| title | A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption |
| title_full | A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption |
| title_fullStr | A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption |
| title_full_unstemmed | A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption |
| title_short | A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption |
| title_sort | protective mechanism of probiotic lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption |
| url | https://doi.org/10.1038/s12276-019-0293-4 |
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