Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia
Shih-Hsiang Liao,1 Chia-Hung Liu,2 Bishnu Prasad Bastakoti,3 Norihiro Suzuki,7 Yung Chang,4 Yusuke Yamauchi,3 Feng-Huei Lin,5,6 Kevin C-W Wu1,6 1Department of Chemical Engineering, National Taiwan University No 1, Taipei, 2Department of Urology, Taipei Medical University-Shuang Ho Hospital, New Tai...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015-05-01
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| Series: | International Journal of Nanomedicine |
| Online Access: | http://www.dovepress.com/functionalized-magnetic-iron-oxidealginate-core-shell-nanoparticles-fo-peer-reviewed-article-IJN |
| _version_ | 1818692224162988032 |
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| author | Liao SH Liu CH Bastakoti BP Suzuki N Chang Y Yamauchi Y Lin FH Wu KCW |
| author_facet | Liao SH Liu CH Bastakoti BP Suzuki N Chang Y Yamauchi Y Lin FH Wu KCW |
| author_sort | Liao SH |
| collection | DOAJ |
| description | Shih-Hsiang Liao,1 Chia-Hung Liu,2 Bishnu Prasad Bastakoti,3 Norihiro Suzuki,7 Yung Chang,4 Yusuke Yamauchi,3 Feng-Huei Lin,5,6 Kevin C-W Wu1,6 1Department of Chemical Engineering, National Taiwan University No 1, Taipei, 2Department of Urology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan; 3National Institute for Materials Science, Ibaraki, Japan; 4R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Taoyua, 5Institute of Biomedical Engineering, National Taiwan University No 1, Taipei City, 6Division of Medical Engineering Research, National Health Research Institutes, Miaoli County, Taiwan, 7International Center for Young Scientists (ICYS), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki, Japan Abstract: Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe3O4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe3O4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic field, the results indicate that Fe3O4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems. Keywords: hyperthermia, iron oxide, alginate, pre-gel, targeting |
| first_indexed | 2024-12-17T12:54:23Z |
| format | Article |
| id | doaj.art-7042fa1076a24f9f83f80cefdcc16646 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-17T12:54:23Z |
| publishDate | 2015-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-7042fa1076a24f9f83f80cefdcc166462022-12-21T21:47:31ZengDove Medical PressInternational Journal of Nanomedicine1178-20132015-05-012015default3315332821586Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermiaLiao SHLiu CHBastakoti BPSuzuki NChang YYamauchi YLin FHWu KCWShih-Hsiang Liao,1 Chia-Hung Liu,2 Bishnu Prasad Bastakoti,3 Norihiro Suzuki,7 Yung Chang,4 Yusuke Yamauchi,3 Feng-Huei Lin,5,6 Kevin C-W Wu1,6 1Department of Chemical Engineering, National Taiwan University No 1, Taipei, 2Department of Urology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan; 3National Institute for Materials Science, Ibaraki, Japan; 4R&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Taoyua, 5Institute of Biomedical Engineering, National Taiwan University No 1, Taipei City, 6Division of Medical Engineering Research, National Health Research Institutes, Miaoli County, Taiwan, 7International Center for Young Scientists (ICYS), National Institute for Materials Science (NIMS), Tsukuba, Ibaraki, Japan Abstract: Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe3O4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe3O4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic field, the results indicate that Fe3O4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems. Keywords: hyperthermia, iron oxide, alginate, pre-gel, targeting http://www.dovepress.com/functionalized-magnetic-iron-oxidealginate-core-shell-nanoparticles-fo-peer-reviewed-article-IJN |
| spellingShingle | Liao SH Liu CH Bastakoti BP Suzuki N Chang Y Yamauchi Y Lin FH Wu KCW Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia International Journal of Nanomedicine |
| title | Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia |
| title_full | Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia |
| title_fullStr | Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia |
| title_full_unstemmed | Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia |
| title_short | Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia |
| title_sort | functionalized magnetic iron oxide alginate core shell nanoparticles for targeting hyperthermia |
| url | http://www.dovepress.com/functionalized-magnetic-iron-oxidealginate-core-shell-nanoparticles-fo-peer-reviewed-article-IJN |
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