Cerebrovascular Impedance as a Function of Cerebral Perfusion Pressure
<italic>Goal:</italic> Cerebrovascular impedance is modulated by a vasoactive autoregulative mechanism in response to changes in cerebral perfusion pressure. Characterization of impedance and the limits of autoregulation are important biomarkers of cerebral health. We developed a method...
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| Format: | Article |
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IEEE
2023-01-01
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| Series: | IEEE Open Journal of Engineering in Medicine and Biology |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/10015702/ |
| _version_ | 1797346302085824512 |
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| author | Jason Yang Deepshikha Acharya William B. Scammon Samantha Schmitt Emily C. Crane Matthew A. Smith Jana M. Kainerstorfer |
| author_facet | Jason Yang Deepshikha Acharya William B. Scammon Samantha Schmitt Emily C. Crane Matthew A. Smith Jana M. Kainerstorfer |
| author_sort | Jason Yang |
| collection | DOAJ |
| description | <italic>Goal:</italic> Cerebrovascular impedance is modulated by a vasoactive autoregulative mechanism in response to changes in cerebral perfusion pressure. Characterization of impedance and the limits of autoregulation are important biomarkers of cerebral health. We developed a method to quantify impedance based on the spectral content of cerebral blood flow and volume at the cardiac frequency, measured with diffuse optical methods. <italic>Methods:</italic> In three non-human primates, we modulated cerebral perfusion pressure beyond the limits of autoregulation. Cerebral blood flow and volume were measured with diffuse correlation spectroscopy and near-infrared spectroscopy, respectively. <italic>Results:</italic> We show that impedance can be used to identify the lower and upper limits of autoregulation. <italic>Conclusions:</italic> This impedance method may be an alternative method to measure autoregulation and a way of assessing cerebral health non-invasively at the clinical bedside. |
| first_indexed | 2024-03-08T11:30:03Z |
| format | Article |
| id | doaj.art-70445dc4a1db41368c5a3ed36063af84 |
| institution | Directory Open Access Journal |
| issn | 2644-1276 |
| language | English |
| last_indexed | 2024-03-08T11:30:03Z |
| publishDate | 2023-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Open Journal of Engineering in Medicine and Biology |
| spelling | doaj.art-70445dc4a1db41368c5a3ed36063af842024-01-26T00:02:07ZengIEEEIEEE Open Journal of Engineering in Medicine and Biology2644-12762023-01-0149610110.1109/OJEMB.2023.323626710015702Cerebrovascular Impedance as a Function of Cerebral Perfusion PressureJason Yang0https://orcid.org/0000-0002-9970-3333Deepshikha Acharya1https://orcid.org/0000-0002-5933-0528William B. Scammon2Samantha Schmitt3Emily C. Crane4https://orcid.org/0000-0002-6207-3163Matthew A. Smith5https://orcid.org/0000-0003-1192-9942Jana M. Kainerstorfer6https://orcid.org/0000-0002-9481-8377Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USADepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USADepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USADepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USADepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USADepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USADepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA<italic>Goal:</italic> Cerebrovascular impedance is modulated by a vasoactive autoregulative mechanism in response to changes in cerebral perfusion pressure. Characterization of impedance and the limits of autoregulation are important biomarkers of cerebral health. We developed a method to quantify impedance based on the spectral content of cerebral blood flow and volume at the cardiac frequency, measured with diffuse optical methods. <italic>Methods:</italic> In three non-human primates, we modulated cerebral perfusion pressure beyond the limits of autoregulation. Cerebral blood flow and volume were measured with diffuse correlation spectroscopy and near-infrared spectroscopy, respectively. <italic>Results:</italic> We show that impedance can be used to identify the lower and upper limits of autoregulation. <italic>Conclusions:</italic> This impedance method may be an alternative method to measure autoregulation and a way of assessing cerebral health non-invasively at the clinical bedside.https://ieeexplore.ieee.org/document/10015702/Cerebral autoregulationcerebral hemodynamicscerebrovascular impedancediffuse correlation spectroscopynear-infrared spectroscopy |
| spellingShingle | Jason Yang Deepshikha Acharya William B. Scammon Samantha Schmitt Emily C. Crane Matthew A. Smith Jana M. Kainerstorfer Cerebrovascular Impedance as a Function of Cerebral Perfusion Pressure IEEE Open Journal of Engineering in Medicine and Biology Cerebral autoregulation cerebral hemodynamics cerebrovascular impedance diffuse correlation spectroscopy near-infrared spectroscopy |
| title | Cerebrovascular Impedance as a Function of Cerebral Perfusion Pressure |
| title_full | Cerebrovascular Impedance as a Function of Cerebral Perfusion Pressure |
| title_fullStr | Cerebrovascular Impedance as a Function of Cerebral Perfusion Pressure |
| title_full_unstemmed | Cerebrovascular Impedance as a Function of Cerebral Perfusion Pressure |
| title_short | Cerebrovascular Impedance as a Function of Cerebral Perfusion Pressure |
| title_sort | cerebrovascular impedance as a function of cerebral perfusion pressure |
| topic | Cerebral autoregulation cerebral hemodynamics cerebrovascular impedance diffuse correlation spectroscopy near-infrared spectroscopy |
| url | https://ieeexplore.ieee.org/document/10015702/ |
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