ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS
Objective: To compare the outcome of intra-articular hyaluronic acid injection with oral non-steroidal antiinflammatory drugs in knee osteoarthritis in terms of mean pain score. Study Design: Randomized controlled trial. Place and Duration of Study: Outpatient orthopedics department of Combine...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2019-04-01
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| Series: | Pakistan Armed Forces Medical Journal |
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| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/2744/2151 |
| _version_ | 1819024961407287296 |
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| author | Usman Aziz Sara Iqbal Tariq Aziz Hina Kanwal Shafaat Saira Jilani |
| author_facet | Usman Aziz Sara Iqbal Tariq Aziz Hina Kanwal Shafaat Saira Jilani |
| author_sort | Usman Aziz |
| collection | DOAJ |
| description | Objective: To compare the outcome of intra-articular hyaluronic acid injection with oral non-steroidal antiinflammatory drugs in knee osteoarthritis in terms of mean pain score.
Study Design: Randomized controlled trial.
Place and Duration of Study: Outpatient orthopedics department of Combined Military Hospital, Rawalpindi from February 2015 to July 2016.
Patients and Methods: A total of 60 patients with knee osteoarthritis were enrolled as per inclusion and exclusion criteria by non-probability consecutive sampling. Thirty patients were assigned to group “A” and were given intra-articular injection of hyaluronic acid 20 mg (2 ml) into the knee joint aseptically for five consecutive weeks. Group “B”, having thirty patients, was given oral non-steroidal anti-inflammatory drug Celecoxib
200mg/Naproxen 500mg twice daily after meals for twelve weeks. Outcome measure was mean pain score using visual analogue scale at twelve week follow-up.
Results: Statistically significant improvement in mean pain score on visual analogue scale at twelve week followup was found in patients of group “A”, with improvement in score from 7.2 ± 0.92 at the start of the study to 5.6 ± 1.23 at twelve week follow-up (p<0.001). No statistically significant results were obtained in patients with group “B” having pain score on visual analogue scale of 7.4 ± 0.94 at the start of the study to 7.3 ± 0.95 at twelve week follow-up (p= 0.373).
Conclusion: The use of intra-articular injection of hyaluronic acid in knee osteoarthritis potentially offers a significantly greater clinical improvement in terms of pain relief, especially in radiological grades 1 to 3. Nonsteroidal anti-inflammatory drugs, on the other hand, are of lower comparative efficacy in the treatment of knee osteoarthritis pain. |
| first_indexed | 2024-12-21T05:03:06Z |
| format | Article |
| id | doaj.art-70445f1caa714025bd6648f69b61ee1e |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-21T05:03:06Z |
| publishDate | 2019-04-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-70445f1caa714025bd6648f69b61ee1e2022-12-21T19:15:12ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422019-04-01692314318ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITISUsman Aziz0Sara Iqbal1Tariq Aziz2Hina Kanwal Shafaat3Saira Jilani4Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanPak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan**Combined Military Hospital Pano Aqil/National University of Medical Sciences (NUMS) PakistanArmed Forces Institute of Rehabilitation Medicine /National University of Medical Sciences (NUMS) Rawalpindi PakistanCombined Military Hospital Abbottabad/National University of Medical Sciences (NUMS) Rawalpindi PakistanObjective: To compare the outcome of intra-articular hyaluronic acid injection with oral non-steroidal antiinflammatory drugs in knee osteoarthritis in terms of mean pain score. Study Design: Randomized controlled trial. Place and Duration of Study: Outpatient orthopedics department of Combined Military Hospital, Rawalpindi from February 2015 to July 2016. Patients and Methods: A total of 60 patients with knee osteoarthritis were enrolled as per inclusion and exclusion criteria by non-probability consecutive sampling. Thirty patients were assigned to group “A” and were given intra-articular injection of hyaluronic acid 20 mg (2 ml) into the knee joint aseptically for five consecutive weeks. Group “B”, having thirty patients, was given oral non-steroidal anti-inflammatory drug Celecoxib 200mg/Naproxen 500mg twice daily after meals for twelve weeks. Outcome measure was mean pain score using visual analogue scale at twelve week follow-up. Results: Statistically significant improvement in mean pain score on visual analogue scale at twelve week followup was found in patients of group “A”, with improvement in score from 7.2 ± 0.92 at the start of the study to 5.6 ± 1.23 at twelve week follow-up (p<0.001). No statistically significant results were obtained in patients with group “B” having pain score on visual analogue scale of 7.4 ± 0.94 at the start of the study to 7.3 ± 0.95 at twelve week follow-up (p= 0.373). Conclusion: The use of intra-articular injection of hyaluronic acid in knee osteoarthritis potentially offers a significantly greater clinical improvement in terms of pain relief, especially in radiological grades 1 to 3. Nonsteroidal anti-inflammatory drugs, on the other hand, are of lower comparative efficacy in the treatment of knee osteoarthritis pain.https://www.pafmj.org/index.php/PAFMJ/article/view/2744/2151osteoarthritisnon-steroidal anti-inflammatory drugsintra-articular injections |
| spellingShingle | Usman Aziz Sara Iqbal Tariq Aziz Hina Kanwal Shafaat Saira Jilani ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS Pakistan Armed Forces Medical Journal osteoarthritis non-steroidal anti-inflammatory drugs intra-articular injections |
| title | ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS |
| title_full | ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS |
| title_fullStr | ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS |
| title_full_unstemmed | ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS |
| title_short | ANTI-INFLAMMATORY DRUGS IN MANAGEMENT OF KNEE OSTEOARTHRITIS |
| title_sort | anti inflammatory drugs in management of knee osteoarthritis |
| topic | osteoarthritis non-steroidal anti-inflammatory drugs intra-articular injections |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/2744/2151 |
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