The Moderated Mediating Effects of Nutrition and Physical Activity Between Fatigue and Quality of Life in Childhood Cancer Survivors
Summary: Purpose: The aim of this study was to investigate the associations between nutrition, physical activity, fatigue, and quality of life (QoL) among childhood cancer survivors. The specific purpose was to examine whether nutrition mediated and physical activity moderated the relationship betw...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Asian Nursing Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S197613172200072X |
| _version_ | 1828000927553945600 |
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| author | Wei-Wen Wu Cheng-Shi Shiu Chia-Chun Tang Shiann-Tang Jou Huey-Ling Chen |
| author_facet | Wei-Wen Wu Cheng-Shi Shiu Chia-Chun Tang Shiann-Tang Jou Huey-Ling Chen |
| author_sort | Wei-Wen Wu |
| collection | DOAJ |
| description | Summary: Purpose: The aim of this study was to investigate the associations between nutrition, physical activity, fatigue, and quality of life (QoL) among childhood cancer survivors. The specific purpose was to examine whether nutrition mediated and physical activity moderated the relationship between fatigue and QoL in this population. Methods: A pooled sample of 120 childhood cancer survivors was recruited at pediatric oncology wards and ambulatory settings between August 2020 and May 2021. We collected data on participants’ demographic characteristics, fatigue, nutritional status, physical activity, and QoL. We then adapted Hayes Process Macro to examine the mediating and moderating effects of nutrition and physical activity on the relationship between fatigue and QoL. Results: In models adjusted for age and sex, (1) the simple mediation analysis identified the mediating effect of nutrition on the relationship between fatigue and QoL; and (2) the mediation and moderation analysis identified that the direct effect of nutrition between fatigue and QoL was significant when adding (a) physical activity and (b) fatigue × physical activity. There were significantly decreasing trends in physical activity at 1 standard deviation below the mean and at the mean, but not at 1 standard deviation above the mean. Conclusions: Our findings demonstrate that nutrition mediated and physical activity moderated the relationship between fatigue and QoL. This highlights an opportunity to enhance QoL among childhood cancer survivors through healthy lifestyle interventions. To ensure that future interventions address children's needs and promote the greatest impact, such interventions should include nutrition and physical activity components that involve nurses, pediatric oncology physicians, nutritionists, and physical therapists. |
| first_indexed | 2024-04-10T06:21:41Z |
| format | Article |
| id | doaj.art-704491666a424683af477bac7f9473d8 |
| institution | Directory Open Access Journal |
| issn | 1976-1317 |
| language | English |
| last_indexed | 2024-04-10T06:21:41Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Nursing Research |
| spelling | doaj.art-704491666a424683af477bac7f9473d82023-03-02T04:59:07ZengElsevierAsian Nursing Research1976-13172023-02-011712329The Moderated Mediating Effects of Nutrition and Physical Activity Between Fatigue and Quality of Life in Childhood Cancer SurvivorsWei-Wen Wu0Cheng-Shi Shiu1Chia-Chun Tang2Shiann-Tang Jou3Huey-Ling Chen4School of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Nursing, National Taiwan University Hospital, Taipei, Taiwan; Corresponding author. School of Nursing, College of Medicine, National Taiwan University, Taiwan.Department of Social Work, National Taiwan University, Taipei, TaiwanSchool of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Nursing, National Taiwan University Hospital, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan; Department of Medicine, College of Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan; Department and Graduate Institute of Medical Education and Bioethics, College of Medicine, National Taiwan University, Taipei, TaiwanSummary: Purpose: The aim of this study was to investigate the associations between nutrition, physical activity, fatigue, and quality of life (QoL) among childhood cancer survivors. The specific purpose was to examine whether nutrition mediated and physical activity moderated the relationship between fatigue and QoL in this population. Methods: A pooled sample of 120 childhood cancer survivors was recruited at pediatric oncology wards and ambulatory settings between August 2020 and May 2021. We collected data on participants’ demographic characteristics, fatigue, nutritional status, physical activity, and QoL. We then adapted Hayes Process Macro to examine the mediating and moderating effects of nutrition and physical activity on the relationship between fatigue and QoL. Results: In models adjusted for age and sex, (1) the simple mediation analysis identified the mediating effect of nutrition on the relationship between fatigue and QoL; and (2) the mediation and moderation analysis identified that the direct effect of nutrition between fatigue and QoL was significant when adding (a) physical activity and (b) fatigue × physical activity. There were significantly decreasing trends in physical activity at 1 standard deviation below the mean and at the mean, but not at 1 standard deviation above the mean. Conclusions: Our findings demonstrate that nutrition mediated and physical activity moderated the relationship between fatigue and QoL. This highlights an opportunity to enhance QoL among childhood cancer survivors through healthy lifestyle interventions. To ensure that future interventions address children's needs and promote the greatest impact, such interventions should include nutrition and physical activity components that involve nurses, pediatric oncology physicians, nutritionists, and physical therapists.http://www.sciencedirect.com/science/article/pii/S197613172200072Xchild nutritional sciencesexercisefatiguequality of life |
| spellingShingle | Wei-Wen Wu Cheng-Shi Shiu Chia-Chun Tang Shiann-Tang Jou Huey-Ling Chen The Moderated Mediating Effects of Nutrition and Physical Activity Between Fatigue and Quality of Life in Childhood Cancer Survivors Asian Nursing Research child nutritional sciences exercise fatigue quality of life |
| title | The Moderated Mediating Effects of Nutrition and Physical Activity Between Fatigue and Quality of Life in Childhood Cancer Survivors |
| title_full | The Moderated Mediating Effects of Nutrition and Physical Activity Between Fatigue and Quality of Life in Childhood Cancer Survivors |
| title_fullStr | The Moderated Mediating Effects of Nutrition and Physical Activity Between Fatigue and Quality of Life in Childhood Cancer Survivors |
| title_full_unstemmed | The Moderated Mediating Effects of Nutrition and Physical Activity Between Fatigue and Quality of Life in Childhood Cancer Survivors |
| title_short | The Moderated Mediating Effects of Nutrition and Physical Activity Between Fatigue and Quality of Life in Childhood Cancer Survivors |
| title_sort | moderated mediating effects of nutrition and physical activity between fatigue and quality of life in childhood cancer survivors |
| topic | child nutritional sciences exercise fatigue quality of life |
| url | http://www.sciencedirect.com/science/article/pii/S197613172200072X |
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