Botulinum Toxin for Neuropathic Pain: A Review of the Literature
Botulinum neurotoxin (BoNT), derived from Clostridium botulinum, has been used therapeutically for focal dystonia, spasticity, and chronic migraine. Its spectrum as a potential treatment for neuropathic pain has grown. Recent opinions on the mechanism behind the antinociceptive effects of BoNT sugge...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-08-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/7/8/3127 |
| _version_ | 1811186484190904320 |
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| author | Hyun-Mi Oh Myung Eun Chung |
| author_facet | Hyun-Mi Oh Myung Eun Chung |
| author_sort | Hyun-Mi Oh |
| collection | DOAJ |
| description | Botulinum neurotoxin (BoNT), derived from Clostridium botulinum, has been used therapeutically for focal dystonia, spasticity, and chronic migraine. Its spectrum as a potential treatment for neuropathic pain has grown. Recent opinions on the mechanism behind the antinociceptive effects of BoNT suggest that it inhibits the release of peripheral neurotransmitters and inflammatory mediators from sensory nerves. There is some evidence showing the axonal transport of BoNT, but it remains controversial. The aim of this review is to summarize the experimental and clinical evidence of the antinociceptive effects, mechanisms, and therapeutic applications of BoNT for neuropathic pain conditions, including postherpetic neuralgia, complex regional pain syndrome, and trigeminal neuralgia. The PubMed and OvidSP databases were searched from 1966 to May 2015. We assessed levels of evidence according to the American Academy of Neurology guidelines. Recent studies have suggested that BoNT injection is an effective treatment for postherpetic neuralgia and is likely efficient for trigeminal neuralgia and post-traumatic neuralgia. BoNT could also be effective as a treatment for diabetic neuropathy. It has not been proven to be an effective treatment for occipital neuralgia or complex regional pain syndrome. |
| first_indexed | 2024-04-11T13:46:11Z |
| format | Article |
| id | doaj.art-7047c63fde044773b619e86d4621cb04 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T13:46:11Z |
| publishDate | 2015-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-7047c63fde044773b619e86d4621cb042022-12-22T04:21:01ZengMDPI AGToxins2072-66512015-08-01783127315410.3390/toxins7083127toxins7083127Botulinum Toxin for Neuropathic Pain: A Review of the LiteratureHyun-Mi Oh0Myung Eun Chung1Department of Rehabilitation Medicine, Seoul St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, KoreaDepartment of Rehabilitation Medicine, St. Paul’s Hospital, College of Medicine, the Catholic University of Korea, Wangsan-ro 180, Dongdaemoon-Gu, Seoul 02559, KoreaBotulinum neurotoxin (BoNT), derived from Clostridium botulinum, has been used therapeutically for focal dystonia, spasticity, and chronic migraine. Its spectrum as a potential treatment for neuropathic pain has grown. Recent opinions on the mechanism behind the antinociceptive effects of BoNT suggest that it inhibits the release of peripheral neurotransmitters and inflammatory mediators from sensory nerves. There is some evidence showing the axonal transport of BoNT, but it remains controversial. The aim of this review is to summarize the experimental and clinical evidence of the antinociceptive effects, mechanisms, and therapeutic applications of BoNT for neuropathic pain conditions, including postherpetic neuralgia, complex regional pain syndrome, and trigeminal neuralgia. The PubMed and OvidSP databases were searched from 1966 to May 2015. We assessed levels of evidence according to the American Academy of Neurology guidelines. Recent studies have suggested that BoNT injection is an effective treatment for postherpetic neuralgia and is likely efficient for trigeminal neuralgia and post-traumatic neuralgia. BoNT could also be effective as a treatment for diabetic neuropathy. It has not been proven to be an effective treatment for occipital neuralgia or complex regional pain syndrome.http://www.mdpi.com/2072-6651/7/8/3127botulinum toxinsBoNT/Aneuropathic painneuralgiaantinociceptive |
| spellingShingle | Hyun-Mi Oh Myung Eun Chung Botulinum Toxin for Neuropathic Pain: A Review of the Literature Toxins botulinum toxins BoNT/A neuropathic pain neuralgia antinociceptive |
| title | Botulinum Toxin for Neuropathic Pain: A Review of the Literature |
| title_full | Botulinum Toxin for Neuropathic Pain: A Review of the Literature |
| title_fullStr | Botulinum Toxin for Neuropathic Pain: A Review of the Literature |
| title_full_unstemmed | Botulinum Toxin for Neuropathic Pain: A Review of the Literature |
| title_short | Botulinum Toxin for Neuropathic Pain: A Review of the Literature |
| title_sort | botulinum toxin for neuropathic pain a review of the literature |
| topic | botulinum toxins BoNT/A neuropathic pain neuralgia antinociceptive |
| url | http://www.mdpi.com/2072-6651/7/8/3127 |
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