The association between lymphocyte-to-monocyte ratio and all-cause mortality in obese hypertensive patients with diabetes and without diabetes: results from the cohort study of NHANES 2001–2018
ObjectiveObesity, hypertension and diabetes are high prevalent that are often associated with poor outcomes. They have become major global health concern. Little research has been done on the impact of lymphocyte-to-monocyte ratio (LMR) on outcomes in these patients. Thus, we aimed to explore the as...
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| Format: | Article |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1387272/full |
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| author | Lixia Wang Jie Gao Bing Liu Youliang Fu Zhihui Yao Shanshan Guo Ziwei Song Zhaoyuan Zhang Jiaojiao He Congxia Wang Weidong Ma Feng Wu |
| author_facet | Lixia Wang Jie Gao Bing Liu Youliang Fu Zhihui Yao Shanshan Guo Ziwei Song Zhaoyuan Zhang Jiaojiao He Congxia Wang Weidong Ma Feng Wu |
| author_sort | Lixia Wang |
| collection | DOAJ |
| description | ObjectiveObesity, hypertension and diabetes are high prevalent that are often associated with poor outcomes. They have become major global health concern. Little research has been done on the impact of lymphocyte-to-monocyte ratio (LMR) on outcomes in these patients. Thus, we aimed to explore the association between LMR and all-cause mortality in obese hypertensive patients with diabetes and without diabetes.MethodsThe researchers analyzed data from the National Health and Nutrition Examination Survey (2001-2018), which included 4,706 participants. Kaplan-Meier analysis was employed to compare survival rate between different groups. Multivariate Cox proportional hazards regression models with trend tests and restricted cubic splines (RCS) analysis and were used to investigate the relationship between the LMR and all-cause mortality. Subgroup analysis was performed to assess whether there was an interaction between the variables.ResultsThe study included a total of 4706 participants with obese hypertension (48.78% male), of whom 960 cases (20.40%) died during follow-up (median follow-up of 90 months). Kaplan–Meier curves suggested a remarkable decrease in all-cause mortality with increasing LMR value in patients with diabetes and non-diabetes (P for log-rank test < 0.001). Moreover, multivariable Cox models demonstrated that the risk of mortality was considerably higher in the lowest quartile of the LMR and no linear trend was observed (P > 0.05). Furthermore, the RCS analysis indicated a non-linear decline in the risk of death as LMR values increased (P for nonlinearity < 0.001).ConclusionsIncreased LMR is independently related with reduced all-cause mortality in patients with obese hypertension, regardless of whether they have combined diabetes. |
| first_indexed | 2024-04-24T09:44:22Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T09:44:22Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-70486006401d48ce8a8e1727e92b5e792024-04-15T04:15:30ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-04-011510.3389/fendo.2024.13872721387272The association between lymphocyte-to-monocyte ratio and all-cause mortality in obese hypertensive patients with diabetes and without diabetes: results from the cohort study of NHANES 2001–2018Lixia Wang0Jie Gao1Bing Liu2Youliang Fu3Zhihui Yao4Shanshan Guo5Ziwei Song6Zhaoyuan Zhang7Jiaojiao He8Congxia Wang9Weidong Ma10Feng Wu11Department of Cardiology, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, ChinaDepartment of Cardiology, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, ChinaDepartment of Cardiology, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, ChinaDepartment of Cardiology, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, ChinaDepartment of Cardiology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Cardiology, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, ChinaDepartment of Cardiology, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, ChinaDepartment of Cardiology, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, ChinaDepartment of Cardiology, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, ChinaDepartment of Cardiology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Cardiology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Cardiology, Xi’an International Medical Center Hospital, Xi’an, Shaanxi, ChinaObjectiveObesity, hypertension and diabetes are high prevalent that are often associated with poor outcomes. They have become major global health concern. Little research has been done on the impact of lymphocyte-to-monocyte ratio (LMR) on outcomes in these patients. Thus, we aimed to explore the association between LMR and all-cause mortality in obese hypertensive patients with diabetes and without diabetes.MethodsThe researchers analyzed data from the National Health and Nutrition Examination Survey (2001-2018), which included 4,706 participants. Kaplan-Meier analysis was employed to compare survival rate between different groups. Multivariate Cox proportional hazards regression models with trend tests and restricted cubic splines (RCS) analysis and were used to investigate the relationship between the LMR and all-cause mortality. Subgroup analysis was performed to assess whether there was an interaction between the variables.ResultsThe study included a total of 4706 participants with obese hypertension (48.78% male), of whom 960 cases (20.40%) died during follow-up (median follow-up of 90 months). Kaplan–Meier curves suggested a remarkable decrease in all-cause mortality with increasing LMR value in patients with diabetes and non-diabetes (P for log-rank test < 0.001). Moreover, multivariable Cox models demonstrated that the risk of mortality was considerably higher in the lowest quartile of the LMR and no linear trend was observed (P > 0.05). Furthermore, the RCS analysis indicated a non-linear decline in the risk of death as LMR values increased (P for nonlinearity < 0.001).ConclusionsIncreased LMR is independently related with reduced all-cause mortality in patients with obese hypertension, regardless of whether they have combined diabetes.https://www.frontiersin.org/articles/10.3389/fendo.2024.1387272/fulllymphocyte-to-monocyte ratio (LMR)all-cause mortalityobesityhypertensiondiabetes |
| spellingShingle | Lixia Wang Jie Gao Bing Liu Youliang Fu Zhihui Yao Shanshan Guo Ziwei Song Zhaoyuan Zhang Jiaojiao He Congxia Wang Weidong Ma Feng Wu The association between lymphocyte-to-monocyte ratio and all-cause mortality in obese hypertensive patients with diabetes and without diabetes: results from the cohort study of NHANES 2001–2018 Frontiers in Endocrinology lymphocyte-to-monocyte ratio (LMR) all-cause mortality obesity hypertension diabetes |
| title | The association between lymphocyte-to-monocyte ratio and all-cause mortality in obese hypertensive patients with diabetes and without diabetes: results from the cohort study of NHANES 2001–2018 |
| title_full | The association between lymphocyte-to-monocyte ratio and all-cause mortality in obese hypertensive patients with diabetes and without diabetes: results from the cohort study of NHANES 2001–2018 |
| title_fullStr | The association between lymphocyte-to-monocyte ratio and all-cause mortality in obese hypertensive patients with diabetes and without diabetes: results from the cohort study of NHANES 2001–2018 |
| title_full_unstemmed | The association between lymphocyte-to-monocyte ratio and all-cause mortality in obese hypertensive patients with diabetes and without diabetes: results from the cohort study of NHANES 2001–2018 |
| title_short | The association between lymphocyte-to-monocyte ratio and all-cause mortality in obese hypertensive patients with diabetes and without diabetes: results from the cohort study of NHANES 2001–2018 |
| title_sort | association between lymphocyte to monocyte ratio and all cause mortality in obese hypertensive patients with diabetes and without diabetes results from the cohort study of nhanes 2001 2018 |
| topic | lymphocyte-to-monocyte ratio (LMR) all-cause mortality obesity hypertension diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1387272/full |
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