Clinicopathological characteristics of histiocytic sarcoma affecting the central nervous system in dogs
Abstract Background Histiocytic sarcoma affecting the central nervous system (CNS HS) in dogs may present as primary or disseminated disease, often characterized by inflammation. Prognosis is poor, and imaging differentiation from other CNS tumors can be problematic. Objective To characterize the cl...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-03-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.15673 |
| _version_ | 1818155633825808384 |
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| author | Izumi Toyoda William Vernau Beverly K. Sturges Karen M. Vernau John Rossmeisl Kurt Zimmerman Chelsea M. Crowe Kevin Woolard Michelle Giuffrida Robert J. Higgins Peter J. Dickinson |
| author_facet | Izumi Toyoda William Vernau Beverly K. Sturges Karen M. Vernau John Rossmeisl Kurt Zimmerman Chelsea M. Crowe Kevin Woolard Michelle Giuffrida Robert J. Higgins Peter J. Dickinson |
| author_sort | Izumi Toyoda |
| collection | DOAJ |
| description | Abstract Background Histiocytic sarcoma affecting the central nervous system (CNS HS) in dogs may present as primary or disseminated disease, often characterized by inflammation. Prognosis is poor, and imaging differentiation from other CNS tumors can be problematic. Objective To characterize the clinicopathological inflammatory features, breed predisposition, and survival in dogs with CNS HS. Animals One hundred two dogs with HS, 62 dogs with meningioma. Methods Retrospective case series. Records were reviewed for results of cerebrospinal fluid (CSF) analysis, CBC, treatment, and outcome data. Results Predisposition for CNS HS was seen in Bernese Mountain Dogs, Golden Retrievers, Rottweilers, Corgis, and Shetland Sheepdogs (P ≤ .001). Corgis and Shetland Sheepdogs had predominantly primary tumors; Rottweilers had exclusively disseminated tumors. Marked CSF inflammation was characteristic of primary rather than disseminated HS, and neoplastic cells were detected in CSF of 52% of affected dogs. Increased neutrophil to lymphocyte ratios were seen in all groups relative to controls (P <.008) but not among tumor subtypes. Definitive versus palliative treatment resulted in improved survival times (P < .001), but overall prognosis was poor. Conclusions and Clinical Importance Clinicopathological differences between primary and disseminated HS suggest that tumor biological behavior and origin may be different. Corgis and Shetland Sheepdogs are predisposed to primary CNS HS, characterized by inflammatory CSF. High total nucleated cell count and the presence of neoplastic cells support the use of CSF analysis as a valuable diagnostic test. Prognosis for CNS HS is poor, but further evaluation of inflammatory mechanisms may provide novel therapeutic opportunities. |
| first_indexed | 2024-12-11T14:45:31Z |
| format | Article |
| id | doaj.art-7048d89df2ce4245aec3c14ff549b82a |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-11T14:45:31Z |
| publishDate | 2020-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-7048d89df2ce4245aec3c14ff549b82a2022-12-22T01:01:42ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762020-03-0134282883710.1111/jvim.15673Clinicopathological characteristics of histiocytic sarcoma affecting the central nervous system in dogsIzumi Toyoda0William Vernau1Beverly K. Sturges2Karen M. Vernau3John Rossmeisl4Kurt Zimmerman5Chelsea M. Crowe6Kevin Woolard7Michelle Giuffrida8Robert J. Higgins9Peter J. Dickinson10Veterinary Medical Teaching Hospital School of Veterinary Medicine, University of California‐Davis Davis CaliforniaDepartment of Pathology, Microbiology and Immunology University of California Davis, School of Veterinary Medicine Davis CaliforniaDepartment of Surgical and Radiological Sciences University of California Davis, School of Veterinary Medicine Davis CaliforniaDepartment of Surgical and Radiological Sciences University of California Davis, School of Veterinary Medicine Davis CaliforniaDepartment of Small Animal Clinical Sciences Virginia‐Maryland College of Veterinary Medicine Blacksburg VirginiaDepartment of Small Animal Clinical Sciences Virginia‐Maryland College of Veterinary Medicine Blacksburg VirginiaVeterinary Medical Teaching Hospital School of Veterinary Medicine, University of California‐Davis Davis CaliforniaDepartment of Pathology, Microbiology and Immunology University of California Davis, School of Veterinary Medicine Davis CaliforniaDepartment of Surgical and Radiological Sciences University of California Davis, School of Veterinary Medicine Davis CaliforniaDepartment of Pathology, Microbiology and Immunology University of California Davis, School of Veterinary Medicine Davis CaliforniaDepartment of Surgical and Radiological Sciences University of California Davis, School of Veterinary Medicine Davis CaliforniaAbstract Background Histiocytic sarcoma affecting the central nervous system (CNS HS) in dogs may present as primary or disseminated disease, often characterized by inflammation. Prognosis is poor, and imaging differentiation from other CNS tumors can be problematic. Objective To characterize the clinicopathological inflammatory features, breed predisposition, and survival in dogs with CNS HS. Animals One hundred two dogs with HS, 62 dogs with meningioma. Methods Retrospective case series. Records were reviewed for results of cerebrospinal fluid (CSF) analysis, CBC, treatment, and outcome data. Results Predisposition for CNS HS was seen in Bernese Mountain Dogs, Golden Retrievers, Rottweilers, Corgis, and Shetland Sheepdogs (P ≤ .001). Corgis and Shetland Sheepdogs had predominantly primary tumors; Rottweilers had exclusively disseminated tumors. Marked CSF inflammation was characteristic of primary rather than disseminated HS, and neoplastic cells were detected in CSF of 52% of affected dogs. Increased neutrophil to lymphocyte ratios were seen in all groups relative to controls (P <.008) but not among tumor subtypes. Definitive versus palliative treatment resulted in improved survival times (P < .001), but overall prognosis was poor. Conclusions and Clinical Importance Clinicopathological differences between primary and disseminated HS suggest that tumor biological behavior and origin may be different. Corgis and Shetland Sheepdogs are predisposed to primary CNS HS, characterized by inflammatory CSF. High total nucleated cell count and the presence of neoplastic cells support the use of CSF analysis as a valuable diagnostic test. Prognosis for CNS HS is poor, but further evaluation of inflammatory mechanisms may provide novel therapeutic opportunities.https://doi.org/10.1111/jvim.15673caninecentral nervous systemcerebrospinal fluidneoplasia |
| spellingShingle | Izumi Toyoda William Vernau Beverly K. Sturges Karen M. Vernau John Rossmeisl Kurt Zimmerman Chelsea M. Crowe Kevin Woolard Michelle Giuffrida Robert J. Higgins Peter J. Dickinson Clinicopathological characteristics of histiocytic sarcoma affecting the central nervous system in dogs Journal of Veterinary Internal Medicine canine central nervous system cerebrospinal fluid neoplasia |
| title | Clinicopathological characteristics of histiocytic sarcoma affecting the central nervous system in dogs |
| title_full | Clinicopathological characteristics of histiocytic sarcoma affecting the central nervous system in dogs |
| title_fullStr | Clinicopathological characteristics of histiocytic sarcoma affecting the central nervous system in dogs |
| title_full_unstemmed | Clinicopathological characteristics of histiocytic sarcoma affecting the central nervous system in dogs |
| title_short | Clinicopathological characteristics of histiocytic sarcoma affecting the central nervous system in dogs |
| title_sort | clinicopathological characteristics of histiocytic sarcoma affecting the central nervous system in dogs |
| topic | canine central nervous system cerebrospinal fluid neoplasia |
| url | https://doi.org/10.1111/jvim.15673 |
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