Transurethral prostate surgery in prostate cancer patients: A population-based comparative analysis of complication and mortality rates
Objective: Prostate cancer (PCa) patients might experience lower urinary tract symptoms as those diagnosed with benign prostatic hyperplasia (BPH). Some of them might be treated for their lower urinary tract symptoms instead of PCa. We aimed to test the effect of PCa versus BPH on surgical outcomes...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Asian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388222000947 |
| _version_ | 1827373978609516544 |
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| author | Michele Marchioni Giulia Primiceri Alessandro Veccia Marta Di Nicola Umberto Carbonara Fabio Crocerossa Ugo Falagario Ambra Rizzoli Riccardo Autorino Luigi Schips |
| author_facet | Michele Marchioni Giulia Primiceri Alessandro Veccia Marta Di Nicola Umberto Carbonara Fabio Crocerossa Ugo Falagario Ambra Rizzoli Riccardo Autorino Luigi Schips |
| author_sort | Michele Marchioni |
| collection | DOAJ |
| description | Objective: Prostate cancer (PCa) patients might experience lower urinary tract symptoms as those diagnosed with benign prostatic hyperplasia (BPH). Some of them might be treated for their lower urinary tract symptoms instead of PCa. We aimed to test the effect of PCa versus BPH on surgical outcomes after transurethral prostate surgery, namely complication and mortality rates. Methods: Within the American College of Surgeons National Surgical Quality Improvement Program database (2011–2016), we identified patients who underwent transurethral resection of the prostate, photoselective vaporization, or laser enucleation. Patients were stratified according to postoperative diagnosis (PCa vs. BPH). Univariable and multivariable logistic regression models evaluated the predictors of perioperative morbidity and mortality. A formal test of interaction between diagnosis and surgical technique used was performed. Results: Overall, 34 542 patients were included. Of all, 2008 (5.8%) had a diagnosis of PCa. The multivariable logistic regression model failed to show statistically significant higher rates of postoperative complications in PCa patients (odds ratio: 0.9, 95% confidence interval: 0.7–1.1; p=0.252). Moreover, similar rates of perioperative mortality (p=0.255), major acute cardiovascular events (p=0.581), transfusions (p=0.933), and length of stay of more than or equal to 30 days (p=0.174) were found. Additionally, all tests failed to show an interaction between post-operative diagnosis and surgical technique used. Conclusion: Patients diagnosed with PCa do not experience higher perioperative morbidity or mortality after transurethral prostate surgery when compared to their BPH counterparts. Moreover, the diagnosis seems to not influence surgical technique outcomes. |
| first_indexed | 2024-03-08T11:25:47Z |
| format | Article |
| id | doaj.art-70492622e81e4b0faae449c4a20914f9 |
| institution | Directory Open Access Journal |
| issn | 2214-3882 |
| language | English |
| last_indexed | 2024-03-08T11:25:47Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj.art-70492622e81e4b0faae449c4a20914f92024-01-26T05:33:22ZengElsevierAsian Journal of Urology2214-38822024-01-011114854Transurethral prostate surgery in prostate cancer patients: A population-based comparative analysis of complication and mortality ratesMichele Marchioni0Giulia Primiceri1Alessandro Veccia2Marta Di Nicola3Umberto Carbonara4Fabio Crocerossa5Ugo Falagario6Ambra Rizzoli7Riccardo Autorino8Luigi Schips9Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, “G. d'Annunzio” University of Chieti, Chieti, Italy; Urology Unit, Department of Medical, Oral and Biotechnological Sciences, “G. d'Annunzio” University of Chieti, Chieti, Italy; Corresponding author. Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, G. D'Annunzio University of Chieti, Chieti, Italy.Urology Unit, Department of Medical, Oral and Biotechnological Sciences, “G. d'Annunzio” University of Chieti, Chieti, ItalyDivision of Urology, VCU Health, Richmond, VA, USALaboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, “G. d'Annunzio” University of Chieti, Chieti, ItalyDivision of Urology, VCU Health, Richmond, VA, USADivision of Urology, VCU Health, Richmond, VA, USADivision of Urology, VCU Health, Richmond, VA, USAUrology Unit, Department of Medical, Oral and Biotechnological Sciences, “G. d'Annunzio” University of Chieti, Chieti, ItalyDivision of Urology, VCU Health, Richmond, VA, USAUrology Unit, Department of Medical, Oral and Biotechnological Sciences, “G. d'Annunzio” University of Chieti, Chieti, ItalyObjective: Prostate cancer (PCa) patients might experience lower urinary tract symptoms as those diagnosed with benign prostatic hyperplasia (BPH). Some of them might be treated for their lower urinary tract symptoms instead of PCa. We aimed to test the effect of PCa versus BPH on surgical outcomes after transurethral prostate surgery, namely complication and mortality rates. Methods: Within the American College of Surgeons National Surgical Quality Improvement Program database (2011–2016), we identified patients who underwent transurethral resection of the prostate, photoselective vaporization, or laser enucleation. Patients were stratified according to postoperative diagnosis (PCa vs. BPH). Univariable and multivariable logistic regression models evaluated the predictors of perioperative morbidity and mortality. A formal test of interaction between diagnosis and surgical technique used was performed. Results: Overall, 34 542 patients were included. Of all, 2008 (5.8%) had a diagnosis of PCa. The multivariable logistic regression model failed to show statistically significant higher rates of postoperative complications in PCa patients (odds ratio: 0.9, 95% confidence interval: 0.7–1.1; p=0.252). Moreover, similar rates of perioperative mortality (p=0.255), major acute cardiovascular events (p=0.581), transfusions (p=0.933), and length of stay of more than or equal to 30 days (p=0.174) were found. Additionally, all tests failed to show an interaction between post-operative diagnosis and surgical technique used. Conclusion: Patients diagnosed with PCa do not experience higher perioperative morbidity or mortality after transurethral prostate surgery when compared to their BPH counterparts. Moreover, the diagnosis seems to not influence surgical technique outcomes.http://www.sciencedirect.com/science/article/pii/S2214388222000947Prostate cancerTransurethral surgery of the prostateProstate surgeryPopulation-based analysisBenign prostatic hyperplasiaLaser surgery |
| spellingShingle | Michele Marchioni Giulia Primiceri Alessandro Veccia Marta Di Nicola Umberto Carbonara Fabio Crocerossa Ugo Falagario Ambra Rizzoli Riccardo Autorino Luigi Schips Transurethral prostate surgery in prostate cancer patients: A population-based comparative analysis of complication and mortality rates Asian Journal of Urology Prostate cancer Transurethral surgery of the prostate Prostate surgery Population-based analysis Benign prostatic hyperplasia Laser surgery |
| title | Transurethral prostate surgery in prostate cancer patients: A population-based comparative analysis of complication and mortality rates |
| title_full | Transurethral prostate surgery in prostate cancer patients: A population-based comparative analysis of complication and mortality rates |
| title_fullStr | Transurethral prostate surgery in prostate cancer patients: A population-based comparative analysis of complication and mortality rates |
| title_full_unstemmed | Transurethral prostate surgery in prostate cancer patients: A population-based comparative analysis of complication and mortality rates |
| title_short | Transurethral prostate surgery in prostate cancer patients: A population-based comparative analysis of complication and mortality rates |
| title_sort | transurethral prostate surgery in prostate cancer patients a population based comparative analysis of complication and mortality rates |
| topic | Prostate cancer Transurethral surgery of the prostate Prostate surgery Population-based analysis Benign prostatic hyperplasia Laser surgery |
| url | http://www.sciencedirect.com/science/article/pii/S2214388222000947 |
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