Interaction of Lipoplex with Albumin Enhances Gene Expression in Hepatitis Mice

Interaction of Lipoplex with Albumin Enhances Gene Expression in Hepatitis Mice

Understanding the in vivo fate of lipoplex, which is composed of cationic liposomes and DNA, is an important issue toward gene therapy. In disease conditions, the fate of lipoplex might change compared with the normal condition. Here, we examined the contribution of interaction with serum components...

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Bibliographic Details
Main Authors: Naoki Yoshikawa, Shintaro Fumoto, Keiko Yoshikawa, Die Hu, Kazuya Okami, Riku Kato, Mikiro Nakashima, Hirotaka Miyamoto, Koyo Nishida
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Pharmaceutics
Subjects:
in vivo gene transfection
lipofection
hepatitis
interaction with serum components
lung
liver
Online Access:https://www.mdpi.com/1999-4923/12/4/341

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