Optical coherence tomography in the evaluation of structural changes in primary open-angle glaucoma with and without elevated intraocular pressure
Background/Aim. Glaucoma is a progressive optic neuropathy characterized by damage of the retinal ganglion cells and their axons and glial cells. The aim of this study was to evaluate the differences and connections between changes in the visual field and the thickness of the peripapillary...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Military Health Department, Ministry of Defance, Serbia
2016-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600068T.pdf |
| Summary: | Background/Aim. Glaucoma is a progressive optic neuropathy characterized by
damage of the retinal ganglion cells and their axons and glial cells. The
aim of this study was to evaluate the differences and connections between
changes in the visual field and the thickness of the peripapillary retinal
nerve fiber layer (RNFL), using optical coherence tomography (OCT) in
patients with primary open-angle glaucoma with normal and elevated
intraocular pressure (IOP). Methods. This prospective study included 38
patients (38 eyes) with primary open-angle glaucoma with normal intraocular
pressure (NTG) and 50 patients (50 eyes) with primary open-angle glaucoma
with elevated intraocular pressure (HTG), paired by the same degree of
structural glaucomatous changes in the optic nerve head and by age. OCT
protocols ’fast RNFL thickness’ and ’fast optic disc’ were used for testing.
The patients’ age, gender, best corrected visual acuity (BCVA), IOP,
stereometric and functional parameters were compared. Results. The average
age of the examined population was 65.49 ± 9.36 (range 44-83) years. There
was no statistically significant difference by age and by gender between the
two study groups (p = 0.795 and p = 0.807, respectively). BCVA was higher in
patients with NTG but there was no statistically significant difference
compared to HTG patients (p = 0.160). IOP was statistically significantly
higher in patients with HTG compared to NTG patients (17.40 ± 2.77 mmHg vs
14.95 ± 3.01 mmHg, p = 0.009). The cup/disc (C/D) (p = 0.258), mean
deviation (MD) (p = 0.477), corrected patern standard deviation (CPSD) (p =
0.943), disk area (p = 0.515), rim area (p = 0.294), rim volume (p = 0.118),
C/D area R (p = 0.103), RNFL Average (p = 0.632), RNFL Superior (p = 0.283)
and RNFL Inferior (p = 0.488) were not statistically significantly different
between the groups. Conclusion. OCT measurements of the RNFL thickness
provide clinically significant information in monitoring of glaucomatous
changes. There are no differences in the patterns of RNFL defects per
sectors and quadrants between NTG and HTG, measured by OCT. |
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| ISSN: | 0042-8450 2406-0720 |