Neural differentiation of human Wharton's jelly-derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke rats
Human Wharton's jelly-derived mesenchymal stem cells (hWJ-MSCs) have excellent proliferative ability, differentiation ability, low immunogenicity, and can be easily obtained. However, there are few studies on their application in the treatment of ischemic stroke, therefore their therapeutic eff...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=7;spage=1103;epage=1110;aulast=Zhang |
| _version_ | 1818324417538686976 |
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| author | Lei Zhang Lin-mei Wang Wei-wei Chen Zhi Ma Xiao Han Cheng-ming Liu Xiang Cheng Wei Shi Jing-jing Guo Jian-bing Qin Xiao-qing Yang Guo-hua Jin Xin-hua Zhang |
| author_facet | Lei Zhang Lin-mei Wang Wei-wei Chen Zhi Ma Xiao Han Cheng-ming Liu Xiang Cheng Wei Shi Jing-jing Guo Jian-bing Qin Xiao-qing Yang Guo-hua Jin Xin-hua Zhang |
| author_sort | Lei Zhang |
| collection | DOAJ |
| description | Human Wharton's jelly-derived mesenchymal stem cells (hWJ-MSCs) have excellent proliferative ability, differentiation ability, low immunogenicity, and can be easily obtained. However, there are few studies on their application in the treatment of ischemic stroke, therefore their therapeutic effect requires further verification. In this study, hWJ-MSCs were transplanted into an ischemic stroke rat model via the tail vein 48 hours after transient middle cerebral artery occlusion. After 4 weeks, neurological functions of the rats implanted with hWJ-MSCs were significantly recovered. Furthermore, many hWJ-MSCs homed to the ischemic frontal cortex whereby they differentiated into neuron-like cells at this region. These results confirm that hWJ-MSCs transplanted into the ischemic stroke rat can differentiate into neuron-like cells to improve rat neurological function and behavior. |
| first_indexed | 2024-12-13T11:28:15Z |
| format | Article |
| id | doaj.art-704b81d67261455c92f4d1c709ab1118 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-13T11:28:15Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-704b81d67261455c92f4d1c709ab11182022-12-21T23:48:06ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742017-01-011271103111010.4103/1673-5374.211189Neural differentiation of human Wharton's jelly-derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke ratsLei ZhangLin-mei WangWei-wei ChenZhi MaXiao HanCheng-ming LiuXiang ChengWei ShiJing-jing GuoJian-bing QinXiao-qing YangGuo-hua JinXin-hua ZhangHuman Wharton's jelly-derived mesenchymal stem cells (hWJ-MSCs) have excellent proliferative ability, differentiation ability, low immunogenicity, and can be easily obtained. However, there are few studies on their application in the treatment of ischemic stroke, therefore their therapeutic effect requires further verification. In this study, hWJ-MSCs were transplanted into an ischemic stroke rat model via the tail vein 48 hours after transient middle cerebral artery occlusion. After 4 weeks, neurological functions of the rats implanted with hWJ-MSCs were significantly recovered. Furthermore, many hWJ-MSCs homed to the ischemic frontal cortex whereby they differentiated into neuron-like cells at this region. These results confirm that hWJ-MSCs transplanted into the ischemic stroke rat can differentiate into neuron-like cells to improve rat neurological function and behavior.http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=7;spage=1103;epage=1110;aulast=Zhangnerve regeneration; human Wharton′s jelly-derived mesenchymal stem cells; ischemic stroke; cell transplantation; middle cerebral artery occlusion; neural differentiation; neurological function; neural regeneration |
| spellingShingle | Lei Zhang Lin-mei Wang Wei-wei Chen Zhi Ma Xiao Han Cheng-ming Liu Xiang Cheng Wei Shi Jing-jing Guo Jian-bing Qin Xiao-qing Yang Guo-hua Jin Xin-hua Zhang Neural differentiation of human Wharton's jelly-derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke rats Neural Regeneration Research nerve regeneration; human Wharton′s jelly-derived mesenchymal stem cells; ischemic stroke; cell transplantation; middle cerebral artery occlusion; neural differentiation; neurological function; neural regeneration |
| title | Neural differentiation of human Wharton's jelly-derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke rats |
| title_full | Neural differentiation of human Wharton's jelly-derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke rats |
| title_fullStr | Neural differentiation of human Wharton's jelly-derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke rats |
| title_full_unstemmed | Neural differentiation of human Wharton's jelly-derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke rats |
| title_short | Neural differentiation of human Wharton's jelly-derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke rats |
| title_sort | neural differentiation of human wharton s jelly derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke rats |
| topic | nerve regeneration; human Wharton′s jelly-derived mesenchymal stem cells; ischemic stroke; cell transplantation; middle cerebral artery occlusion; neural differentiation; neurological function; neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=7;spage=1103;epage=1110;aulast=Zhang |
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