Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma
Papillary hidradenoma/ mammary-like gland adenoma (MLGA) is a benign glandular tumor of the vulva. It presents as a mass lesion which often undergoes secondary ulceration and bleeding resembling a malignant tumor. It arises from specialized anogenital glands in the labial folds which resemble mammar...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Barpeta Obstetrics and Gynaecological Society
2021-07-01
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| Series: | New Indian Journal of OBGYN |
| Subjects: | |
| Online Access: | https://journal.barpetaogs.co.in/pdf/08143.pdf |
| _version_ | 1818456013640040448 |
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| author | Deval Parekh Sunaina Wadhwa Asima Mukhopadhyay Angad Singh |
| author_facet | Deval Parekh Sunaina Wadhwa Asima Mukhopadhyay Angad Singh |
| author_sort | Deval Parekh |
| collection | DOAJ |
| description | Papillary hidradenoma/ mammary-like gland adenoma (MLGA) is a benign glandular tumor of the vulva. It presents as a mass lesion which often undergoes secondary ulceration and bleeding resembling a malignant tumor. It arises from specialized anogenital glands in the labial folds which resemble mammary glands on microscopy. The tumour shows a tubulo-papillary architecture and is composed of bland columnar cells with apical snouting. GATA-3 is a transcription factor and it’s expression is essential for normal mammary gland development. GATA-3 immunohistochemistry (IHC) is positive in luminal cells of breast and its positive in ductal hyperplasia as well as in breast carcinoma. In summary, we describe a case of a benign vulval mammary gland like adenoma with diffuse GATA-3 expression which was originally diagnosed as a malignant low-grade polymorphous adenocarcinoma and discuss its clinical and associated histopathological findings. |
| first_indexed | 2024-12-14T22:19:55Z |
| format | Article |
| id | doaj.art-704ba7b6a898482892a0a9968b98a4e7 |
| institution | Directory Open Access Journal |
| issn | 2454-2334 2454-2342 |
| language | English |
| last_indexed | 2024-12-14T22:19:55Z |
| publishDate | 2021-07-01 |
| publisher | Barpeta Obstetrics and Gynaecological Society |
| record_format | Article |
| series | New Indian Journal of OBGYN |
| spelling | doaj.art-704ba7b6a898482892a0a9968b98a4e72022-12-21T22:45:31ZengBarpeta Obstetrics and Gynaecological SocietyNew Indian Journal of OBGYN2454-23342454-23422021-07-018114314510.21276/obgyn.2021.8.1.28Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinomaDeval Parekh0Sunaina Wadhwa1Asima Mukhopadhyay2Angad Singh3Department of Pathology, Tata Medical Center, Kolkata, IndiaDepartment of Gynaecologic Oncology, Tata Medical Center, Kolkata, IndiaDepartment of Gynaecologic Oncology, Tata Medical Center, Kolkata, IndiaDepartment of Pathology, Tata Medical Center, Kolkata, IndiaPapillary hidradenoma/ mammary-like gland adenoma (MLGA) is a benign glandular tumor of the vulva. It presents as a mass lesion which often undergoes secondary ulceration and bleeding resembling a malignant tumor. It arises from specialized anogenital glands in the labial folds which resemble mammary glands on microscopy. The tumour shows a tubulo-papillary architecture and is composed of bland columnar cells with apical snouting. GATA-3 is a transcription factor and it’s expression is essential for normal mammary gland development. GATA-3 immunohistochemistry (IHC) is positive in luminal cells of breast and its positive in ductal hyperplasia as well as in breast carcinoma. In summary, we describe a case of a benign vulval mammary gland like adenoma with diffuse GATA-3 expression which was originally diagnosed as a malignant low-grade polymorphous adenocarcinoma and discuss its clinical and associated histopathological findings.https://journal.barpetaogs.co.in/pdf/08143.pdfmammary like gland adenomapapillary hidradenomavulvagata-3 |
| spellingShingle | Deval Parekh Sunaina Wadhwa Asima Mukhopadhyay Angad Singh Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma New Indian Journal of OBGYN mammary like gland adenoma papillary hidradenoma vulva gata-3 |
| title | Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma |
| title_full | Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma |
| title_fullStr | Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma |
| title_full_unstemmed | Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma |
| title_short | Mammary like gland adenoma with GATA-3 expression - a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma |
| title_sort | mammary like gland adenoma with gata 3 expression a benign vulval tumor with mammary differentiation often misdiagnosed as adenocarcinoma |
| topic | mammary like gland adenoma papillary hidradenoma vulva gata-3 |
| url | https://journal.barpetaogs.co.in/pdf/08143.pdf |
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