Expressing the quantity of urinary analytes: a discussion of some issues arising from the monitoring of the menstrual cycle
Practical domestic monitoring of the menstrual cycle requires measurements of urinary metabolites of reproductive hormones: oestrone glucuronide (E1G) and pregnanediol glucuronide (PdG). Data reported in the literature are expressed as (i) concentration, without or with either creatinine- or specifi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2020-03-01
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| Series: | Open Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/openhe-2020-0001 |
| _version_ | 1797743788372787200 |
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| author | Brown Simon Cooke Delwyn G. Blackwell Leonard F. |
| author_facet | Brown Simon Cooke Delwyn G. Blackwell Leonard F. |
| author_sort | Brown Simon |
| collection | DOAJ |
| description | Practical domestic monitoring of the menstrual cycle requires measurements of urinary metabolites of reproductive hormones: oestrone glucuronide (E1G) and pregnanediol glucuronide (PdG). Data reported in the literature are expressed as (i) concentration, without or with either creatinine- or specific gravity correction, or (ii) excretion rates. This variation in such a fundamental issue prompts consideration of the relationships between the four measures. Because the menstrual cycle kinetics of E1G and PdG are complex, we consider measurements of urinary creatinine, urea, galactose, xylose and inulin which tend to be more stable. We show that uncorrected concentration measurements of these urinary analytes can be positively correlated, negatively correlated or uncorrelated with the serum concentration. Based on measurements of urinary creatinine concentrations, urinary specific gravity and creatinine excretion rates, we conclude that urinary analyte concentration are likely to be more reliable when creatinine-corrected rather than corrected using specific gravity, but that both are less reliable than measurements of the excretion rate. This has implications for the quantitation of any urinary analyte, but especially for the monitoring of the menstrual cycle in which changes in E1G and PdG from one day to the next can be physiologically significant for a woman monitoring her fertility. |
| first_indexed | 2024-03-12T15:00:28Z |
| format | Article |
| id | doaj.art-704dffc96abd46b1a33c2af549ebf8cd |
| institution | Directory Open Access Journal |
| issn | 2544-9826 |
| language | English |
| last_indexed | 2024-03-12T15:00:28Z |
| publishDate | 2020-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Health |
| spelling | doaj.art-704dffc96abd46b1a33c2af549ebf8cd2023-08-14T07:07:52ZengDe GruyterOpen Health2544-98262020-03-011112010.1515/openhe-2020-0001Expressing the quantity of urinary analytes: a discussion of some issues arising from the monitoring of the menstrual cycleBrown Simon0Cooke Delwyn G.1Blackwell Leonard F.2Deviot Institute, Deviot, Tasmania 7275, Australia; College of Public Health, Medical and Veterinary, Sciences, James Cook University, Queensland 4811, AustraliaScience Haven Limited, Palmerston North, New ZealandInstitute of Fundamental Sciences, Massey University, Palmerston North, New ZealandPractical domestic monitoring of the menstrual cycle requires measurements of urinary metabolites of reproductive hormones: oestrone glucuronide (E1G) and pregnanediol glucuronide (PdG). Data reported in the literature are expressed as (i) concentration, without or with either creatinine- or specific gravity correction, or (ii) excretion rates. This variation in such a fundamental issue prompts consideration of the relationships between the four measures. Because the menstrual cycle kinetics of E1G and PdG are complex, we consider measurements of urinary creatinine, urea, galactose, xylose and inulin which tend to be more stable. We show that uncorrected concentration measurements of these urinary analytes can be positively correlated, negatively correlated or uncorrelated with the serum concentration. Based on measurements of urinary creatinine concentrations, urinary specific gravity and creatinine excretion rates, we conclude that urinary analyte concentration are likely to be more reliable when creatinine-corrected rather than corrected using specific gravity, but that both are less reliable than measurements of the excretion rate. This has implications for the quantitation of any urinary analyte, but especially for the monitoring of the menstrual cycle in which changes in E1G and PdG from one day to the next can be physiologically significant for a woman monitoring her fertility.https://doi.org/10.1515/openhe-2020-0001concentrationcreatinineexcretion ratemenstrual cyclespecific gravityurine |
| spellingShingle | Brown Simon Cooke Delwyn G. Blackwell Leonard F. Expressing the quantity of urinary analytes: a discussion of some issues arising from the monitoring of the menstrual cycle Open Health concentration creatinine excretion rate menstrual cycle specific gravity urine |
| title | Expressing the quantity of urinary analytes: a discussion of some issues arising from the monitoring of the menstrual cycle |
| title_full | Expressing the quantity of urinary analytes: a discussion of some issues arising from the monitoring of the menstrual cycle |
| title_fullStr | Expressing the quantity of urinary analytes: a discussion of some issues arising from the monitoring of the menstrual cycle |
| title_full_unstemmed | Expressing the quantity of urinary analytes: a discussion of some issues arising from the monitoring of the menstrual cycle |
| title_short | Expressing the quantity of urinary analytes: a discussion of some issues arising from the monitoring of the menstrual cycle |
| title_sort | expressing the quantity of urinary analytes a discussion of some issues arising from the monitoring of the menstrual cycle |
| topic | concentration creatinine excretion rate menstrual cycle specific gravity urine |
| url | https://doi.org/10.1515/openhe-2020-0001 |
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