Genotypic‐specific heat shock response of vector susceptibility to Schistosoma mansoni
Abstract Living organisms are vulnerable to thermal stress, which causes a diversity of physiological outcomes. Previous work has shown that the snail vectors (Biomphalaria glabrata) of an important human pathogen, Schistosoma mansoni, revert from resistant to susceptible after short exposure to a h...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-08-01
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| Series: | Ecosphere |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ecs2.4207 |
| _version_ | 1818494358797680640 |
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| author | Johannie M. Spaan Nathaniel Leavitt Jessica Shen Taylor Bundy Lillian Burrows Christopher Ingram Thomas R. Maehara Ibrahim Ndungu Martin Mutuku George Owino Maurice Odiere Michelle L. Steinauer |
| author_facet | Johannie M. Spaan Nathaniel Leavitt Jessica Shen Taylor Bundy Lillian Burrows Christopher Ingram Thomas R. Maehara Ibrahim Ndungu Martin Mutuku George Owino Maurice Odiere Michelle L. Steinauer |
| author_sort | Johannie M. Spaan |
| collection | DOAJ |
| description | Abstract Living organisms are vulnerable to thermal stress, which causes a diversity of physiological outcomes. Previous work has shown that the snail vectors (Biomphalaria glabrata) of an important human pathogen, Schistosoma mansoni, revert from resistant to susceptible after short exposure to a heat stress as low as 31°C; however, due to lack of replicability among labs and genetic lines of snails, it has been hypothesized that this effect is genotype dependent. We examined the effects of heat shock on the resistance of two species of snail vectors including B. glabrata and Biomphalaria sudanica. We used three different inbred laboratory snail lines in addition to the F1 generation of field‐collected snails from Lake Victoria, Kenya, an area with high levels of schistosomiasis transmission. Our results showed marginal effects of heat shock on prevalence of infection in B. glabrata, and that this response was genotype specific. We found no evidence of a heat shock effect on prevalence of infection in B. sudanica or on intensity of infection (number of infectious stages shed) in either snail species. Such environmentally influenced defense responses stress the importance of considering this unique interaction between snail and parasite genotypes in determining infection dynamics under climate changes. |
| first_indexed | 2024-12-10T18:05:06Z |
| format | Article |
| id | doaj.art-704ed3c2c6cb438e8e62c0cc399ea97d |
| institution | Directory Open Access Journal |
| issn | 2150-8925 |
| language | English |
| last_indexed | 2024-12-10T18:05:06Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Ecosphere |
| spelling | doaj.art-704ed3c2c6cb438e8e62c0cc399ea97d2022-12-22T01:38:38ZengWileyEcosphere2150-89252022-08-01138n/an/a10.1002/ecs2.4207Genotypic‐specific heat shock response of vector susceptibility to Schistosoma mansoniJohannie M. Spaan0Nathaniel Leavitt1Jessica Shen2Taylor Bundy3Lillian Burrows4Christopher Ingram5Thomas R. Maehara6Ibrahim Ndungu7Martin Mutuku8George Owino9Maurice Odiere10Michelle L. Steinauer11Department of Basic Medical Sciences Western University of Health Sciences Lebanon Oregon USADepartment of Basic Medical Sciences Western University of Health Sciences Lebanon Oregon USADepartment of Basic Medical Sciences Western University of Health Sciences Lebanon Oregon USADepartment of Medicine Oregon Health and Science University Portland Oregon USADepartment of Basic Medical Sciences Western University of Health Sciences Lebanon Oregon USADepartment of Basic Medical Sciences Western University of Health Sciences Lebanon Oregon USAHomer Stryker M.D. School of Medicine Western Michigan University Kalamazoo Michigan USACentre for Biotechnology Research and Development Kenya Medical Research Institute Nairobi KenyaCentre for Biotechnology Research and Development Kenya Medical Research Institute Nairobi KenyaNeglected Tropical Diseases Unit, Center for Global Health Research Kenya Medical Research Institute Kisumu KenyaNeglected Tropical Diseases Unit, Center for Global Health Research Kenya Medical Research Institute Kisumu KenyaDepartment of Basic Medical Sciences Western University of Health Sciences Lebanon Oregon USAAbstract Living organisms are vulnerable to thermal stress, which causes a diversity of physiological outcomes. Previous work has shown that the snail vectors (Biomphalaria glabrata) of an important human pathogen, Schistosoma mansoni, revert from resistant to susceptible after short exposure to a heat stress as low as 31°C; however, due to lack of replicability among labs and genetic lines of snails, it has been hypothesized that this effect is genotype dependent. We examined the effects of heat shock on the resistance of two species of snail vectors including B. glabrata and Biomphalaria sudanica. We used three different inbred laboratory snail lines in addition to the F1 generation of field‐collected snails from Lake Victoria, Kenya, an area with high levels of schistosomiasis transmission. Our results showed marginal effects of heat shock on prevalence of infection in B. glabrata, and that this response was genotype specific. We found no evidence of a heat shock effect on prevalence of infection in B. sudanica or on intensity of infection (number of infectious stages shed) in either snail species. Such environmentally influenced defense responses stress the importance of considering this unique interaction between snail and parasite genotypes in determining infection dynamics under climate changes.https://doi.org/10.1002/ecs2.4207Biomphalaria glabrataBiomphalaria sudanicaclimate changeecoimmunologythermal stress |
| spellingShingle | Johannie M. Spaan Nathaniel Leavitt Jessica Shen Taylor Bundy Lillian Burrows Christopher Ingram Thomas R. Maehara Ibrahim Ndungu Martin Mutuku George Owino Maurice Odiere Michelle L. Steinauer Genotypic‐specific heat shock response of vector susceptibility to Schistosoma mansoni Ecosphere Biomphalaria glabrata Biomphalaria sudanica climate change ecoimmunology thermal stress |
| title | Genotypic‐specific heat shock response of vector susceptibility to Schistosoma mansoni |
| title_full | Genotypic‐specific heat shock response of vector susceptibility to Schistosoma mansoni |
| title_fullStr | Genotypic‐specific heat shock response of vector susceptibility to Schistosoma mansoni |
| title_full_unstemmed | Genotypic‐specific heat shock response of vector susceptibility to Schistosoma mansoni |
| title_short | Genotypic‐specific heat shock response of vector susceptibility to Schistosoma mansoni |
| title_sort | genotypic specific heat shock response of vector susceptibility to schistosoma mansoni |
| topic | Biomphalaria glabrata Biomphalaria sudanica climate change ecoimmunology thermal stress |
| url | https://doi.org/10.1002/ecs2.4207 |
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