Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy
Photothermal therapy (PTT) using a near-infrared (NIR) heptamethine cyanine fluorophore has emerged as an alternative strategy for targeted cancer therapy. NIR fluorophores showing a high molar extinction coefficient and low fluorescence quantum yield have considerable potential applications in phot...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/9/1286 |
| _version_ | 1797711514110525440 |
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| author | Sungsu Lee Jin Seok Jung Gayoung Jo Dae Hyeok Yang Yang Seok Koh Hoon Hyun |
| author_facet | Sungsu Lee Jin Seok Jung Gayoung Jo Dae Hyeok Yang Yang Seok Koh Hoon Hyun |
| author_sort | Sungsu Lee |
| collection | DOAJ |
| description | Photothermal therapy (PTT) using a near-infrared (NIR) heptamethine cyanine fluorophore has emerged as an alternative strategy for targeted cancer therapy. NIR fluorophores showing a high molar extinction coefficient and low fluorescence quantum yield have considerable potential applications in photothermal cancer therapy. In this study, a bifunctional sorbitol−ZW800 conjugate was used as an advanced concept of photothermal therapeutic agents for in vivo cancer imaging and therapy owing to the high tumor targetability of the sorbitol moiety and excellent photothermal property of NIR heptamethine cyanine fluorophore. The sorbitol−ZW800 showed an excellent photothermal effect increased by 58.7 °C after NIR laser irradiation (1.1 W/cm<sup>2</sup>) for 5 min. The HT-29 tumors targeted by sorbitol−ZW800 showed a significant decrease in tumor volumes for 7 days after photothermal treatment. Therefore, combining the bifunctional sorbitol−ZW800 conjugate and NIR laser irradiation is an alternative way for targeted cancer therapy, and this approach holds great promise as a safe and highly efficient NIR photothermal agent for future clinical applications. |
| first_indexed | 2024-03-12T07:08:09Z |
| format | Article |
| id | doaj.art-704f930fe7214e96a2c25d7af4c12926 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T07:08:09Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-704f930fe7214e96a2c25d7af4c129262023-09-02T23:17:18ZengMDPI AGCancers2072-66942019-09-01119128610.3390/cancers11091286cancers11091286Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer TherapySungsu Lee0Jin Seok Jung1Gayoung Jo2Dae Hyeok Yang3Yang Seok Koh4Hoon Hyun5Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun 58128, KoreaDepartment of Biomedical Sciences, Chonnam National University Medical School, Hwasun 58128, KoreaDepartment of Biomedical Sciences, Chonnam National University Medical School, Hwasun 58128, KoreaInstitute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaDepartment of Surgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun 58128, KoreaDepartment of Biomedical Sciences, Chonnam National University Medical School, Hwasun 58128, KoreaPhotothermal therapy (PTT) using a near-infrared (NIR) heptamethine cyanine fluorophore has emerged as an alternative strategy for targeted cancer therapy. NIR fluorophores showing a high molar extinction coefficient and low fluorescence quantum yield have considerable potential applications in photothermal cancer therapy. In this study, a bifunctional sorbitol−ZW800 conjugate was used as an advanced concept of photothermal therapeutic agents for in vivo cancer imaging and therapy owing to the high tumor targetability of the sorbitol moiety and excellent photothermal property of NIR heptamethine cyanine fluorophore. The sorbitol−ZW800 showed an excellent photothermal effect increased by 58.7 °C after NIR laser irradiation (1.1 W/cm<sup>2</sup>) for 5 min. The HT-29 tumors targeted by sorbitol−ZW800 showed a significant decrease in tumor volumes for 7 days after photothermal treatment. Therefore, combining the bifunctional sorbitol−ZW800 conjugate and NIR laser irradiation is an alternative way for targeted cancer therapy, and this approach holds great promise as a safe and highly efficient NIR photothermal agent for future clinical applications.https://www.mdpi.com/2072-6694/11/9/1286photothermal therapynear-infrared fluorescence imagingtumor targetingsorbitolZW800-1 |
| spellingShingle | Sungsu Lee Jin Seok Jung Gayoung Jo Dae Hyeok Yang Yang Seok Koh Hoon Hyun Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy Cancers photothermal therapy near-infrared fluorescence imaging tumor targeting sorbitol ZW800-1 |
| title | Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy |
| title_full | Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy |
| title_fullStr | Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy |
| title_full_unstemmed | Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy |
| title_short | Near-Infrared Fluorescent Sorbitol Probe for Targeted Photothermal Cancer Therapy |
| title_sort | near infrared fluorescent sorbitol probe for targeted photothermal cancer therapy |
| topic | photothermal therapy near-infrared fluorescence imaging tumor targeting sorbitol ZW800-1 |
| url | https://www.mdpi.com/2072-6694/11/9/1286 |
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