Facial Fabrication of Large-Scale SERS-Active Substrate Based on Self-Assembled Monolayer of Silver Nanoparticles on CTAB-Modified Silicon for Analytical Applications
Surface-enhanced Raman spectroscopy (SERS) has been proven to be a promising analytical technique with sensitivity at the single-molecule level. However, one of the key problems preventing its real-world application lies in the great challenges that are encountered in the preparation of large-scale,...
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MDPI AG
2021-11-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/12/3250 |
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| author | Juanjuan Guo Yang Xu Caili Fu Longhua Guo |
| author_facet | Juanjuan Guo Yang Xu Caili Fu Longhua Guo |
| author_sort | Juanjuan Guo |
| collection | DOAJ |
| description | Surface-enhanced Raman spectroscopy (SERS) has been proven to be a promising analytical technique with sensitivity at the single-molecule level. However, one of the key problems preventing its real-world application lies in the great challenges that are encountered in the preparation of large-scale, reproducible, and highly sensitive SERS-active substrates. In this work, a new strategy is developed to fabricate an Ag collide SERS substrate by using cetyltrimethylammonium bromide (CTAB) as a connection agent. The developed SERS substrate can be developed on a large scale and is highly efficient, and it has high-density “hot spots” that enhance the yield enormously. We employed 4-methylbenzenethiol(4-MBT) as the SERS probe due to the strong Ag–S linkage. The SERS enhancement factor (EF) was calculated to be ~2.6 × 10<sup>6</sup>. The efficacy of the proposed substrate is demonstrated for the detection of malachite green (MG) as an example. The limit of detection (LOD) for the MG assay is brought down to 1.0 × 10<sup>−11</sup> M, and the relative standard deviation (RSD) for the intensity of the main Raman vibration modes (1620, 1038 cm<sup>−1</sup>) is less than 20%. |
| first_indexed | 2024-03-10T03:27:20Z |
| format | Article |
| id | doaj.art-705149f71f9e40a6b133ab2c00384a71 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T03:27:20Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-705149f71f9e40a6b133ab2c00384a712023-11-23T09:50:00ZengMDPI AGNanomaterials2079-49912021-11-011112325010.3390/nano11123250Facial Fabrication of Large-Scale SERS-Active Substrate Based on Self-Assembled Monolayer of Silver Nanoparticles on CTAB-Modified Silicon for Analytical ApplicationsJuanjuan Guo0Yang Xu1Caili Fu2Longhua Guo3College of Oceanology and Food Sciences, Quanzhou Normal University, Quanzhou 362000, ChinaCollege of Physics & Information Engineering, Quanzhou Normal University, Quanzhou 362000, ChinaNational University of Singapore (Suzhou) Research Institute, No. 377 Linquan Street, Suzhou Industrial Park, Suzhou 215128, ChinaCollege of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, ChinaSurface-enhanced Raman spectroscopy (SERS) has been proven to be a promising analytical technique with sensitivity at the single-molecule level. However, one of the key problems preventing its real-world application lies in the great challenges that are encountered in the preparation of large-scale, reproducible, and highly sensitive SERS-active substrates. In this work, a new strategy is developed to fabricate an Ag collide SERS substrate by using cetyltrimethylammonium bromide (CTAB) as a connection agent. The developed SERS substrate can be developed on a large scale and is highly efficient, and it has high-density “hot spots” that enhance the yield enormously. We employed 4-methylbenzenethiol(4-MBT) as the SERS probe due to the strong Ag–S linkage. The SERS enhancement factor (EF) was calculated to be ~2.6 × 10<sup>6</sup>. The efficacy of the proposed substrate is demonstrated for the detection of malachite green (MG) as an example. The limit of detection (LOD) for the MG assay is brought down to 1.0 × 10<sup>−11</sup> M, and the relative standard deviation (RSD) for the intensity of the main Raman vibration modes (1620, 1038 cm<sup>−1</sup>) is less than 20%.https://www.mdpi.com/2079-4991/11/12/3250surface-enhanced Raman spectroscopy (SERS)SERS-active substrateself-assembled monolayersilver nanoparticlesenhancement factor |
| spellingShingle | Juanjuan Guo Yang Xu Caili Fu Longhua Guo Facial Fabrication of Large-Scale SERS-Active Substrate Based on Self-Assembled Monolayer of Silver Nanoparticles on CTAB-Modified Silicon for Analytical Applications Nanomaterials surface-enhanced Raman spectroscopy (SERS) SERS-active substrate self-assembled monolayer silver nanoparticles enhancement factor |
| title | Facial Fabrication of Large-Scale SERS-Active Substrate Based on Self-Assembled Monolayer of Silver Nanoparticles on CTAB-Modified Silicon for Analytical Applications |
| title_full | Facial Fabrication of Large-Scale SERS-Active Substrate Based on Self-Assembled Monolayer of Silver Nanoparticles on CTAB-Modified Silicon for Analytical Applications |
| title_fullStr | Facial Fabrication of Large-Scale SERS-Active Substrate Based on Self-Assembled Monolayer of Silver Nanoparticles on CTAB-Modified Silicon for Analytical Applications |
| title_full_unstemmed | Facial Fabrication of Large-Scale SERS-Active Substrate Based on Self-Assembled Monolayer of Silver Nanoparticles on CTAB-Modified Silicon for Analytical Applications |
| title_short | Facial Fabrication of Large-Scale SERS-Active Substrate Based on Self-Assembled Monolayer of Silver Nanoparticles on CTAB-Modified Silicon for Analytical Applications |
| title_sort | facial fabrication of large scale sers active substrate based on self assembled monolayer of silver nanoparticles on ctab modified silicon for analytical applications |
| topic | surface-enhanced Raman spectroscopy (SERS) SERS-active substrate self-assembled monolayer silver nanoparticles enhancement factor |
| url | https://www.mdpi.com/2079-4991/11/12/3250 |
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