Seaweed sulphated polysaccharide as an inhibitor of calcium oxalate renal stone formation
Sulphated polysaccharides (SPSs) from various seaweeds possess broad spectrum therapeutic and biomedical properties that are known to play a significant inhibitory role in calcium oxalate (CaOx) kidney stones. CaOx stone formation is a multistep process, which includes crystal nucleation, growth, ag...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-12-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464616303292 |
| _version_ | 1818596333247791104 |
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| author | Poonam Bhadja Jignesh Lunagariya Jian-Ming Ouyang |
| author_facet | Poonam Bhadja Jignesh Lunagariya Jian-Ming Ouyang |
| author_sort | Poonam Bhadja |
| collection | DOAJ |
| description | Sulphated polysaccharides (SPSs) from various seaweeds possess broad spectrum therapeutic and biomedical properties that are known to play a significant inhibitory role in calcium oxalate (CaOx) kidney stones. CaOx stone formation is a multistep process, which includes crystal nucleation, growth, aggregation, and crystal retention. Renal tubular cell injury is one of the determining factors leading to crystal retention and formation of stone in the nidus. In the present review, a comprehensive account was revealed on the therapeutic mechanisms of action of various seaweed SPSs on CaOx renal stone formation. Seaweed SPSs are inhibitor of crystal nucleation, growth, and aggregation. SPSs prevent renal tubular cell damage because of its antioxidant properties, thereby preventing crystal adherence and internalization. Seaweed SPSs are promising molecules because of their role in renal stone prevention. This study contributed much interest for researchers in a wide spectrum. |
| first_indexed | 2024-12-16T11:30:14Z |
| format | Article |
| id | doaj.art-7051d8031c814981992cf629b7675619 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-16T11:30:14Z |
| publishDate | 2016-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-7051d8031c814981992cf629b76756192022-12-21T22:33:15ZengElsevierJournal of Functional Foods1756-46462016-12-0127685694Seaweed sulphated polysaccharide as an inhibitor of calcium oxalate renal stone formationPoonam Bhadja0Jignesh Lunagariya1Jian-Ming Ouyang2Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, ChinaInstitute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, ChinaCorresponding author. Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China. Fax: 0086-20-8522 3353.; Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, ChinaSulphated polysaccharides (SPSs) from various seaweeds possess broad spectrum therapeutic and biomedical properties that are known to play a significant inhibitory role in calcium oxalate (CaOx) kidney stones. CaOx stone formation is a multistep process, which includes crystal nucleation, growth, aggregation, and crystal retention. Renal tubular cell injury is one of the determining factors leading to crystal retention and formation of stone in the nidus. In the present review, a comprehensive account was revealed on the therapeutic mechanisms of action of various seaweed SPSs on CaOx renal stone formation. Seaweed SPSs are inhibitor of crystal nucleation, growth, and aggregation. SPSs prevent renal tubular cell damage because of its antioxidant properties, thereby preventing crystal adherence and internalization. Seaweed SPSs are promising molecules because of their role in renal stone prevention. This study contributed much interest for researchers in a wide spectrum.http://www.sciencedirect.com/science/article/pii/S1756464616303292Seaweed sulphated polysaccharideCalcium oxalateRenal stone formation |
| spellingShingle | Poonam Bhadja Jignesh Lunagariya Jian-Ming Ouyang Seaweed sulphated polysaccharide as an inhibitor of calcium oxalate renal stone formation Journal of Functional Foods Seaweed sulphated polysaccharide Calcium oxalate Renal stone formation |
| title | Seaweed sulphated polysaccharide as an inhibitor of calcium oxalate renal stone formation |
| title_full | Seaweed sulphated polysaccharide as an inhibitor of calcium oxalate renal stone formation |
| title_fullStr | Seaweed sulphated polysaccharide as an inhibitor of calcium oxalate renal stone formation |
| title_full_unstemmed | Seaweed sulphated polysaccharide as an inhibitor of calcium oxalate renal stone formation |
| title_short | Seaweed sulphated polysaccharide as an inhibitor of calcium oxalate renal stone formation |
| title_sort | seaweed sulphated polysaccharide as an inhibitor of calcium oxalate renal stone formation |
| topic | Seaweed sulphated polysaccharide Calcium oxalate Renal stone formation |
| url | http://www.sciencedirect.com/science/article/pii/S1756464616303292 |
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