A Trade-Off for Maintenance of Multidrug-Resistant IncHI2 Plasmids in Salmonella enterica Serovar Typhimurium through Adaptive Evolution

A Trade-Off for Maintenance of Multidrug-Resistant IncHI2 Plasmids in Salmonella enterica Serovar Typhimurium through Adaptive Evolution

ABSTRACT Understanding the fitness costs associated with plasmid carriage is a key to better understanding the mechanisms of plasmid maintenance in bacteria. In the current work, we performed multiple serial passages (63 days, 627.8 generations) to identify the compensatory mechanisms that Salmonell...

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Bibliographic Details
Main Authors: Jin-Fei Zhang, Liang-Xing Fang, Man-Xia Chang, Ming Cheng, Hui Zhang, Teng-Fei Long, Qian Li, Xin-lei Lian, Jian Sun, Xiao-Ping Liao, Ya-Hong Liu
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mSystems
Subjects:
IncHI2 plasmid
Salmonella
fitness cost
adaptive evolution
plasmid stability
compensatory mutation
Online Access:https://journals.asm.org/doi/10.1128/msystems.00248-22

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