The Anti-Inflammatory Properties of Mesenchymal Stem Cells in Epilepsy: Possible Treatments and Future Perspectives
Mesenchymal stem cells (MSCs) are multipotent adult cells with self-renewing capacities. MSCs display specific properties, such as the ability to repair damaged tissues, resulting in optimal candidates for cell therapy against degenerative diseases. In addition to the reparative functions of MSCs, g...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/24/9683 |
| _version_ | 1797544143721857024 |
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| author | Valentina Salari Francesca Mengoni Federico Del Gallo Giuseppe Bertini Paolo Francesco Fabene |
| author_facet | Valentina Salari Francesca Mengoni Federico Del Gallo Giuseppe Bertini Paolo Francesco Fabene |
| author_sort | Valentina Salari |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are multipotent adult cells with self-renewing capacities. MSCs display specific properties, such as the ability to repair damaged tissues, resulting in optimal candidates for cell therapy against degenerative diseases. In addition to the reparative functions of MSCs, growing evidence shows that these cells have potent immunomodulatory and anti-inflammatory properties. Therefore, MSCs are potential tools for treating inflammation-related neurological diseases, including epilepsy. In this regard, over the last decades, epilepsy has no longer been considered a purely neuronal pathology, since inflammatory events underlying the genesis of epilepsy have been demonstrated. This review assessed current knowledge on the use of MSCs in the treatment of epilepsy. Mostly, attention will be focused on the anti-inflammatory and immunological skills of MSCs. Understanding the mechanisms by which MSCs might modulate the severity of the disease will contribute to the development of new potential alternatives for both prophylaxis and treatment against epilepsy. |
| first_indexed | 2024-03-10T13:56:12Z |
| format | Article |
| id | doaj.art-70567ce0f191404d8428c608db859208 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:56:12Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-70567ce0f191404d8428c608db8592082023-11-21T01:36:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-12-012124968310.3390/ijms21249683The Anti-Inflammatory Properties of Mesenchymal Stem Cells in Epilepsy: Possible Treatments and Future PerspectivesValentina Salari0Francesca Mengoni1Federico Del Gallo2Giuseppe Bertini3Paolo Francesco Fabene4Department of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, 37134 Verona, ItalyDepartment of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, 37134 Verona, ItalyDepartment of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, 37134 Verona, ItalyDepartment of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, 37134 Verona, ItalyDepartment of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, 37134 Verona, ItalyMesenchymal stem cells (MSCs) are multipotent adult cells with self-renewing capacities. MSCs display specific properties, such as the ability to repair damaged tissues, resulting in optimal candidates for cell therapy against degenerative diseases. In addition to the reparative functions of MSCs, growing evidence shows that these cells have potent immunomodulatory and anti-inflammatory properties. Therefore, MSCs are potential tools for treating inflammation-related neurological diseases, including epilepsy. In this regard, over the last decades, epilepsy has no longer been considered a purely neuronal pathology, since inflammatory events underlying the genesis of epilepsy have been demonstrated. This review assessed current knowledge on the use of MSCs in the treatment of epilepsy. Mostly, attention will be focused on the anti-inflammatory and immunological skills of MSCs. Understanding the mechanisms by which MSCs might modulate the severity of the disease will contribute to the development of new potential alternatives for both prophylaxis and treatment against epilepsy.https://www.mdpi.com/1422-0067/21/24/9683neurological disordersepileptogenesisinflammationepileptic seizurecell therapy |
| spellingShingle | Valentina Salari Francesca Mengoni Federico Del Gallo Giuseppe Bertini Paolo Francesco Fabene The Anti-Inflammatory Properties of Mesenchymal Stem Cells in Epilepsy: Possible Treatments and Future Perspectives International Journal of Molecular Sciences neurological disorders epileptogenesis inflammation epileptic seizure cell therapy |
| title | The Anti-Inflammatory Properties of Mesenchymal Stem Cells in Epilepsy: Possible Treatments and Future Perspectives |
| title_full | The Anti-Inflammatory Properties of Mesenchymal Stem Cells in Epilepsy: Possible Treatments and Future Perspectives |
| title_fullStr | The Anti-Inflammatory Properties of Mesenchymal Stem Cells in Epilepsy: Possible Treatments and Future Perspectives |
| title_full_unstemmed | The Anti-Inflammatory Properties of Mesenchymal Stem Cells in Epilepsy: Possible Treatments and Future Perspectives |
| title_short | The Anti-Inflammatory Properties of Mesenchymal Stem Cells in Epilepsy: Possible Treatments and Future Perspectives |
| title_sort | anti inflammatory properties of mesenchymal stem cells in epilepsy possible treatments and future perspectives |
| topic | neurological disorders epileptogenesis inflammation epileptic seizure cell therapy |
| url | https://www.mdpi.com/1422-0067/21/24/9683 |
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