Immunologic Dose-Response to Adenovirus-Vectored Vaccines in Animals and Humans: A Systematic Review of Dose-Response Studies of Replication Incompetent Adenoviral Vaccine Vectors when Given via an Intramuscular or Subcutaneous Route

Immunologic Dose-Response to Adenovirus-Vectored Vaccines in Animals and Humans: A Systematic Review of Dose-Response Studies of Replication Incompetent Adenoviral Vaccine Vectors when Given via an Intramuscular or Subcutaneous Route

Optimal vaccine dosing is important to ensure the greatest protection and safety. Analysis of dose-response data, from previous studies, may inform future studies to determine the optimal dose. Implementing more quantitative modelling approaches in vaccine dose finding have been recently suggested t...

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Bibliographic Details
Main Authors: Sara Afrough, Sophie Rhodes, Thomas Evans, Richard White, John Benest
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Vaccines
Subjects:
dosing
dose-response
adenovirus-vectored vaccines
immunogenicity
clinical
pre-clinical
Online Access:https://www.mdpi.com/2076-393X/8/1/131

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